INT168248

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 11
Disease Relevance 7.42
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Fabp1) mitosis (Fabp1) transport (Fabp1)
nucleus (Fabp1) cytoplasm (Fabp1)
Anatomy Link Frequency
liver 6
intestines 1
Fabp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 126 98.76 Very High Very High Very High
Inflammatory response 54 96.44 Very High Very High Very High
Inflammation 198 92.16 High High
anesthesia 51 90.24 High High
Inflammatory stimuli 9 70.24 Quite High
cytokine 9 5.00 Very Low Very Low Very Low
isoflurane 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 303 100.00 Very High Very High Very High
Cv Unclassified Under Development 126 98.76 Very High Very High Very High
INFLAMMATION 261 96.08 Very High Very High Very High
Death 27 84.32 Quite High
Reperfusion Injury 9 82.12 Quite High
Liver Failure 45 78.40 Quite High
Toxicity 2 78.40 Quite High
Cirrhosis 9 77.36 Quite High
Hepatotoxicity 9 76.20 Quite High
Metastasis 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some intestinal L-FABP release could have been expected when L-FABP, which is also expressed by the intestines, would have been released from injured enterocytes, but the absence of intestinal L-FABP release clearly indicates that organ manipulation during liver resection results in hepatocellular injury without causing intestinal injury.
Gene_expression (expressed) of L-FABP in liver associated with injury
1) Confidence 0.43 Published 2007 Journal World J Surg Section Body Doc Link PMC2039834 Disease Relevance 0.75 Pain Relevance 0.25
Since L-FABP is expressed in both the liver and the intestines, we performed an organ balance analysis to reveal the origin of circulating L-FABP.
Gene_expression (expressed) of L-FABP in intestines
2) Confidence 0.43 Published 2007 Journal World J Surg Section Body Doc Link PMC2039834 Disease Relevance 0.35 Pain Relevance 0.10
Fig. 1Mean (SEM) arterial L-FABP (a), GST?
Gene_expression (arterial) of L-FABP
3) Confidence 0.37 Published 2007 Journal World J Surg Section Body Doc Link PMC2039834 Disease Relevance 0.69 Pain Relevance 0.16
Surprisingly, we found no additional effect of organ transection or intermittent Pringle maneuver on these increased L-FABP and GST?
Gene_expression (these) of L-FABP
4) Confidence 0.37 Published 2007 Journal World J Surg Section Body Doc Link PMC2039834 Disease Relevance 0.90 Pain Relevance 0.18
The kidneys efficiently removed L-FABP from circulation.
Gene_expression (removed) of L-FABP
5) Confidence 0.37 Published 2007 Journal World J Surg Section Body Doc Link PMC2039834 Disease Relevance 0.05 Pain Relevance 0
By elimination of other potential causes, it thus must be concluded that increasing L-FABP levels occurs during and due to liver manipulation in patients undergoing liver resection.
Gene_expression (levels) of L-FABP in liver
6) Confidence 0.37 Published 2007 Journal World J Surg Section Body Doc Link PMC2039834 Disease Relevance 0.34 Pain Relevance 0.11
Fig. 2Mean (SEM) plasma L-FABP levels in four patients undergoing lower abdominal surgery without manipulation of the liver.
Gene_expression (levels) of L-FABP in liver
7) Confidence 0.37 Published 2007 Journal World J Surg Section Body Doc Link PMC2039834 Disease Relevance 0.44 Pain Relevance 0.11
Both L-FABP and GST?
Gene_expression (Both) of L-FABP
8) Confidence 0.37 Published 2007 Journal World J Surg Section Body Doc Link PMC2039834 Disease Relevance 1.44 Pain Relevance 0.34
Surprisingly, arterial L-FABP levels did not change significantly during subsequent intermittent Pringle maneuver, indicating that neither intermittent ischemia-reperfusion nor liver transection significantly aggravated the hepatocellular injury caused by early perioperative processes.
Gene_expression (levels) of L-FABP in liver associated with ischemia and injury
9) Confidence 0.37 Published 2007 Journal World J Surg Section Body Doc Link PMC2039834 Disease Relevance 0.43 Pain Relevance 0.08
Innovative technologies such as functional genomics and proteomics have facilitated detection of several promising early biomarkers of AKI, such as neutrophil gelatinase-associated lipocalin (NGAL), cystatin C (CyC), liver-type fatty acid binding protein (L-FABP), interleukin-18 (IL-18), and kidney injury molecule-1 (KIM-1).
Gene_expression (detection) of L-FABP in liver associated with injury
10) Confidence 0.13 Published 2010 Journal Minerva Anestesiol Section Abstract Doc Link 20473256 Disease Relevance 1.02 Pain Relevance 0.17
Innovative technologies such as functional genomics and proteomics have facilitated detection of several promising early biomarkers of AKI, such as neutrophil gelatinase-associated lipocalin (NGAL), cystatin C (CyC), liver-type fatty acid binding protein (L-FABP), interleukin-18 (IL-18), and kidney injury molecule-1 (KIM-1).
Gene_expression (detection) of liver-type fatty acid binding protein in liver associated with injury
11) Confidence 0.11 Published 2010 Journal Minerva Anestesiol Section Abstract Doc Link 20473256 Disease Relevance 1.02 Pain Relevance 0.16

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