INT168257

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Context Info
Confidence 0.02
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 4.25
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (MLL) nucleus (MLL) protein complex assembly (MLL)
DNA binding (MLL)
Anatomy Link Frequency
bridges 1
MLL (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 17 99.68 Very High Very High Very High
Etanercept 3 99.44 Very High Very High Very High
Inflammation 4 98.08 Very High Very High Very High
rheumatoid arthritis 2 86.88 High High
spinal inflammation 1 85.12 High High
psoriasis 1 83.20 Quite High
Arthritis 1 81.52 Quite High
Potency 16 43.04 Quite Low
isoflurane 6 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 3 100.00 Very High Very High Very High
Cancer 3 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 17 99.16 Very High Very High Very High
Henipavirus Infections 3 98.38 Very High Very High Very High
INFLAMMATION 4 98.08 Very High Very High Very High
Endophthalmitis 1 98.00 Very High Very High Very High
Infection 213 96.84 Very High Very High Very High
Autoimmune Disease 1 93.20 High High
Disease 51 87.60 High High
Respiratory Syncytial Virus 21 87.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While the sE may contain sulphated glycans, it was not bound by the CR fusion protein (Figure 1B), and so the CR domain of the MR is not expected to contribute to the binding of MR to DV.
CR fusion protein Binding (bound) of
1) Confidence 0.02 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0 Pain Relevance 0
For paramyxoviruses, however, peptides that bind the viral fusion protein have been shown to inhibit fusion in vitro, but not in vivo.
viral fusion protein Binding (bind) of
2) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC2965769 Disease Relevance 1.06 Pain Relevance 0
KH902 is a humanized fusion protein, which is aimed to bind to all forms of VEGF-A.
fusion protein Binding (bind) of
3) Confidence 0.01 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2267739 Disease Relevance 0.72 Pain Relevance 0
For the paramyxoviruses in analogy to HIV, F-derived peptides have been thought to interact with the fusion protein intermediate that exists after activation of the pre-cleaved F protein and the insertion of the fusion peptide into the target cell: this extended intermediate bridges the viral and cell membranes, and its refolding into a 6HB is a key driver for membrane fusion [45].
fusion protein Binding (interact) of in bridges associated with acquired immune deficiency syndrome or hiv infection
4) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2965769 Disease Relevance 1.00 Pain Relevance 0
We have shown that peptides derived from the HRC of HPIV3 F are effective inhibitors of both HPIV3 and henipavirus infection [13], [42], and that the efficacy of inhibition depends on both the strength of interaction of the peptide with the target fusion protein and the time window of access to the target sequence.
fusion protein Binding (interaction) of associated with henipavirus infections
5) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2965769 Disease Relevance 0.27 Pain Relevance 0
Etanercept is a tumor necrosis factor recombinant fusion protein consisting of two molecules of the tumor necrosis factor p75 receptor, which binds to the cytokine and thus antagonizes its effect.
recombinant fusion protein Binding (binds) of associated with necrosis, cancer, etanercept and cytokine
6) Confidence 0.01 Published 2005 Journal Expert Rev Clin Immunol Section Abstract Doc Link 20476983 Disease Relevance 1.20 Pain Relevance 0.53

General Comments

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