INT168263

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Context Info
Confidence 0.58
First Reported 2003
Last Reported 2011
Negated 3
Speculated 0
Reported most in Body
Documents 57
Total Number 57
Disease Relevance 47.10
Pain Relevance 17.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (IL23A)
Anatomy Link Frequency
macrophages 6
joints 4
skin 4
T cells 4
Th17 cells 3
IL23A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 1023 100.00 Very High Very High Very High
rheumatoid arthritis 1919 99.98 Very High Very High Very High
psoriasis 805 99.96 Very High Very High Very High
agonist 123 99.44 Very High Very High Very High
Inflammation 947 99.16 Very High Very High Very High
Etanercept 159 98.04 Very High Very High Very High
Osteoarthritis 210 96.60 Very High Very High Very High
Inflammatory mediators 49 96.00 Very High Very High Very High
antagonist 132 93.92 High High
Central nervous system 105 93.84 High High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 1922 99.98 Very High Very High Very High
Cancer 968 99.98 Very High Very High Very High
Psoriasis 963 99.96 Very High Very High Very High
Autoimmune Disease 84 99.92 Very High Very High Very High
Sarcoidosis 337 99.84 Very High Very High Very High
Disease 796 99.36 Very High Very High Very High
Infection 684 99.28 Very High Very High Very High
INFLAMMATION 1025 99.16 Very High Very High Very High
Candida Infection 64 98.30 Very High Very High Very High
Inflammatory Bowel Disease 166 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of IL-12p40, IL-23p19, CCR7 and iNOS from most of the samples were below the detection limit (data not shown).
Gene_expression (expression) of IL-23
1) Confidence 0.58 Published 2010 Journal Respir Res Section Body Doc Link PMC2939603 Disease Relevance 0.38 Pain Relevance 0
Expression of IL-23p19 in lesional tissue in psoriasis,25 Crohn’s disease26 and rheumatoid arthritis27 support this possible role.
Gene_expression (Expression) of IL-23 associated with psoriasis
2) Confidence 0.58 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880344 Disease Relevance 0.25 Pain Relevance 0.17
Expression of IL-23p19 in lesional tissue in psoriasis,25 Crohn’s disease26 and rheumatoid arthritis27 support this possible role.
Gene_expression (Expression) of IL-23p19 associated with psoriasis
3) Confidence 0.58 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880344 Disease Relevance 0.25 Pain Relevance 0.17
The expression of IL-12p40, IL-23p19, CCR7 and iNOS from most of the samples were below the detection limit (data not shown).
Gene_expression (expression) of IL-23p19
4) Confidence 0.58 Published 2010 Journal Respir Res Section Body Doc Link PMC2939603 Disease Relevance 0.38 Pain Relevance 0
The tendency to a less pronounced upregulation of IL-23p19 expression in sarcoidosis patients after LPS stimulation, made us believe that this could have an impact on the induction of Th17 cells.
Gene_expression (expression) of IL-23p19 in Th17 cells associated with sarcoidosis
5) Confidence 0.58 Published 2010 Journal Respir Res Section Body Doc Link PMC2939603 Disease Relevance 0.41 Pain Relevance 0
Using real-time PCR, the relative gene expression of IL-10, IL-12p35, IL-12p40, IL-23p19, CCR2, CCR7, iNOS, CXCL10, CXCL11, CXCL16, CCL18, CCL20, CD80, and CD86, and innate immune receptors TLR2, TLR4, and TLR9, was quantified in sorted AMs, and for selected genes in total BAL cells, while IL-17A was quantified in T cells.


Gene_expression (expression) of IL-23p19 in T cells
6) Confidence 0.58 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2939603 Disease Relevance 0.72 Pain Relevance 0.04
Candida infection in both immune competent and immunosuppressed mice generally leads to enhanced IL-23p19 expression.
Gene_expression (expression) of p19 associated with candida infection
7) Confidence 0.58 Published 2011 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2963117 Disease Relevance 0.84 Pain Relevance 0.10
However, our data are consistent with recent evidence showing that bioactive IL-23 (p19/p40) was barely detectable in joints of patients with RA [47].
Gene_expression (detectable) of p19 in joints associated with rheumatoid arthritis
8) Confidence 0.58 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991017 Disease Relevance 0.34 Pain Relevance 0.14
Using real-time PCR, the relative gene expression of IL-10, IL-12p35, IL-12p40, IL-23p19, CCR2, CCR7, iNOS, CXCL10, CXCL11, CXCL16, CCL18, CCL20, CD80, and CD86, and innate immune receptors TLR2, TLR4, and TLR9, was quantified in sorted AMs, and for selected genes in total BAL cells, while IL-17A was quantified in T cells.


Gene_expression (expression) of IL-23 in T cells
9) Confidence 0.58 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2939603 Disease Relevance 0.72 Pain Relevance 0.04
In the cytokine model (Figure 1), sentinel cells in symptomless skin start producing IL-23 secondary to an unknown stimulus, and possible TNF.21 It is important to highlight that these sentinel cells, previously considered to be macrophages and resident dermal dendritic cells (DCs), are currently considered by many investigators to be a different population of DCs that appear during inflammation, called “inflammatory” dermal DCs.
Gene_expression (producing) of IL-23 in DCs associated with inflammation and cytokine
10) Confidence 0.47 Published 2010 Journal Core Evidence Section Body Doc Link PMC2915500 Disease Relevance 0.68 Pain Relevance 0.40
, are increased significantly in psoriatic skin in comparison to the other dermal DCs populations, and they are thought to contain an even more specialized DCs subset that has the ability to produce mediators like TNF and intracellular nitric oxide synthase.22 The later have been termed TIP-DCs (TNF and inducible nitric oxide synthase producing DCs), and are held accountable for the production of IL-23.23
Gene_expression (production) of IL-23 in DCs associated with psoriasis
11) Confidence 0.45 Published 2010 Journal Core Evidence Section Body Doc Link PMC2915500 Disease Relevance 0.43 Pain Relevance 0.20
Immunohistochemical analyses have revealed p40 and p19 (subunits of IL-23) protein expression in dermal dendritic cells and keratinocytes of lesional psoriatic skin.31,32 Genetic studies have shown that a single nucleotide polymorphism in p40 (the common subunit of both IL-12 and IL-23)33 as well as polymorphisms in the gene encoding p1934 (IL-23 specific) was associated with the development of psoriasis.
Gene_expression (expression) of IL-23 in skin associated with psoriasis
12) Confidence 0.40 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 0.93 Pain Relevance 0.28
IL-22 is also increased in psoriatic lesions and in plasma and these levels correlate with disease severity.18 Multiple reports have also implicated the IL-23 dependent IL-22, but not IL-17 production, in protective immunity to infection with gram-negative organisms such as Salmonella enteritidis in the respiratory and digestive epithelium.19–21 Recently, a Th22 cell subpopulation (characterized by the secretion of IL-22 and TNF-?)
Gene_expression (production) of IL-23 in respiratory associated with psoriasis, disease and infection
13) Confidence 0.40 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 1.26 Pain Relevance 0.31
It is suggested that certain genetic alteration of the IL-23 (p40 and p19) or IL-12 (p40 and p35) subunits as well as the IL-23 receptor or its ligand will lead to enhanced IL-23 production and subsequent psoriasis susceptibility.
Gene_expression (production) of IL-23 associated with psoriasis
14) Confidence 0.40 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 1.01 Pain Relevance 0.45
Immunohistochemical analyses have revealed p40 and p19 (subunits of IL-23) protein expression in dermal dendritic cells and keratinocytes of lesional psoriatic skin.31,32 Genetic studies have shown that a single nucleotide polymorphism in p40 (the common subunit of both IL-12 and IL-23)33 as well as polymorphisms in the gene encoding p1934 (IL-23 specific) was associated with the development of psoriasis.
Gene_expression (expression) of p19 in skin associated with psoriasis
15) Confidence 0.40 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 0.94 Pain Relevance 0.28
Consistent with this observation, employing immunohistochemistry, IL-23p19 was expressed abundantly in RA ST [14,25].
Gene_expression (expressed) of IL-23p19 associated with rheumatoid arthritis
16) Confidence 0.35 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575607 Disease Relevance 1.03 Pain Relevance 0.55
Suggesting the importance of therapy in the expression of IL-23, these authors demonstrated a significant correlation between the levels of IL-23 and IL-17 in the RA SF before the initiation of etanercept [15].
Gene_expression (levels) of IL-23 associated with rheumatoid arthritis and etanercept
17) Confidence 0.35 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575607 Disease Relevance 0.87 Pain Relevance 0.38
Similar to IL-23, the levels of IFN-?
Gene_expression (levels) of IL-23
18) Confidence 0.35 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575607 Disease Relevance 0.93 Pain Relevance 0.47
Even though IL-23 p19/p40 was very low in RA SF, macrophages isolated from RA SF had significantly increased IL-23 p19 mRNA expression (four-fold increase) compared with control macrophages.
Gene_expression (expression) of IL-23 p19 mRNA in macrophages associated with rheumatoid arthritis
19) Confidence 0.35 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575607 Disease Relevance 1.01 Pain Relevance 0.52
Further, RA SF macrophages stimulated with PGN expressed significantly higher levels of IL-23 mRNA compared with control macrophages treated similarly.
Gene_expression (expressed) of IL-23 mRNA in macrophages associated with rheumatoid arthritis
20) Confidence 0.35 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575607 Disease Relevance 1.04 Pain Relevance 0.55

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