INT168271

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Context Info
Confidence 0.45
First Reported 2009
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.91
Pain Relevance 1.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Faah) Golgi apparatus (Faah) endoplasmic reticulum (Faah)
cytoplasm (Faah)
Anatomy Link Frequency
DA neurons 2
Faah (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nicotine 9 99.84 Very High Very High Very High
Ventral tegmentum 7 98.24 Very High Very High Very High
Dopamine 8 98.08 Very High Very High Very High
Cannabinoid 26 96.96 Very High Very High Very High
Nucleus accumbens 2 94.44 High High
cocaine 5 93.72 High High
Morphine 4 93.24 High High
amygdala 4 89.60 High High
Hippocampus 4 88.80 High High
Central grey 30 86.32 High High
Disease Link Frequency Relevance Heat
Recurrence 1 98.60 Very High Very High Very High
Anxiety Disorder 61 95.76 Very High Very High Very High
Urological Neuroanatomy 33 86.32 High High
Panic Disorder 1 64.16 Quite High
Pain 5 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Agoraphobia 1 5.00 Very Low Very Low Very Low
Nociception 1 5.00 Very Low Very Low Very Low
Shock 1 5.00 Very Low Very Low Very Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we studied whether effects of FAAH inhibition on nicotine-induced changes in activity of VTA DA neurons were specific for nicotine or extended to two drugs of abuse acting through different mechanisms, cocaine and morphine.
Spec (whether) Regulation (effects) of FAAH Neg (inhibition) Binding (inhibition) of in DA neurons associated with ventral tegmentum, dopamine, nicotine, morphine and cocaine
1) Confidence 0.45 Published 2010 Journal Addict Biol Section Abstract Doc Link 20477753 Disease Relevance 0.10 Pain Relevance 1.37
putative protein responsible for internalization of AEA and the enzyme FAAH,
Regulation (responsible) of FAAH Binding (internalization) of
2) Confidence 0.31 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2593468 Disease Relevance 0.81 Pain Relevance 0.44

General Comments

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