INT168274

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Context Info
Confidence 0.03
First Reported 2004
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.19
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Mapk4) cell cycle (Mapk4) cytoplasm (Mapk4)
Anatomy Link Frequency
spinal cord 1
Mapk4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cancer pain 5 99.88 Very High Very High Very High
Pain 1 99.80 Very High Very High Very High
Spinal cord 2 98.28 Very High Very High Very High
Hippocampus 44 97.40 Very High Very High Very High
Hyperalgesia 1 87.24 High High
Stimulus evoked pain 1 80.60 Quite High
Spontaneous pain 2 68.36 Quite High
Brush evoked pain 2 67.52 Quite High
cytokine 2 50.40 Quite High
Neuropathic pain 1 42.16 Quite Low
Disease Link Frequency Relevance Heat
Stress 134 99.92 Very High Very High Very High
Cancer Pain 5 99.88 Very High Very High Very High
Pain 4 99.80 Very High Very High Very High
Hyperalgesia 1 87.24 High High
Hypersensitivity 1 80.60 Quite High
Cancer 3 75.00 Quite High
Neuropathic Pain 3 67.52 Quite High
INFLAMMATION 3 41.32 Quite Low
Depression 8 5.00 Very Low Very Low Very Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results demonstrate that TLR4-dependent phosphorylation of p38MAPK in spinal cord of rats might contribute to the development and maintenance of bone cancer pain, and p38MAPK and TLR4 would possibly be the potential targets for pain therapy.
Regulation (targets) of p38MAPK in spinal cord associated with pain, cancer pain and spinal cord
1) Confidence 0.03 Published 2010 Journal Brain Res. Section Abstract Doc Link 20478276 Disease Relevance 0.92 Pain Relevance 0.80
However, P-Erk and P-p38MAPK levels were unchanged in both restrained and swim stressed mice.
Neg (unchanged) Regulation (unchanged) of p38MAPK
2) Confidence 0.01 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.70 Pain Relevance 0.08
As for swim stress, P-p38MAPK was not altered.
Neg (not) Regulation (altered) of p38MAPK associated with stress
3) Confidence 0.01 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.58 Pain Relevance 0.09

General Comments

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