INT168275

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Context Info
Confidence 0.79
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 2.39
Pain Relevance 2.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1b) aging (Il1b) extracellular region (Il1b)
Anatomy Link Frequency
spinal cord 1
Il1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 4 100.00 Very High Very High Very High
Cancer pain 10 99.54 Very High Very High Very High
Spinal cord 4 99.08 Very High Very High Very High
Spontaneous pain 4 99.06 Very High Very High Very High
Brush evoked pain 4 98.64 Very High Very High Very High
Neuropathic pain 2 94.32 High High
Inflammation 2 93.48 High High
Stimulus evoked pain 2 85.76 High High
Hyperalgesia 2 71.76 Quite High
Pain 2 40.40 Quite Low
Disease Link Frequency Relevance Heat
Cancer Pain 10 99.54 Very High Very High Very High
Cancer 6 99.14 Very High Very High Very High
Pain 8 99.06 Very High Very High Very High
Neuropathic Pain 6 98.64 Very High Very High Very High
INFLAMMATION 2 93.48 High High
Hypersensitivity 2 85.36 High High
Hyperalgesia 2 71.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have demonstrated that tactile allodynia and spontaneous pain of female rats with tibia tumors were correlated with the increase of both phosphorylated-p38MAPK (p-p38MAPK) and proinflammatory cytokines (IL-1beta and TNF-alpha) in the spinal cord 6 days after Walker 256 cells' inoculation.
Phosphorylation (phosphorylated) of IL-1beta in spinal cord associated with pain, brush evoked pain, cancer, spontaneous pain, spinal cord and cytokine
1) Confidence 0.79 Published 2010 Journal Brain Res. Section Abstract Doc Link 20478276 Disease Relevance 1.09 Pain Relevance 0.93
On the other hand, a 3-day administration [4 microg/rat/day, intrathecally (i.t.)] of 4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole (SB203580), an inhibitor of p38MAPK, could suppress tactile allodynia and spontaneous pain of the bone cancer pain rats and decrease the phosphorylation of p38 as well as the expression of IL-1beta and TNF-alpha.
Phosphorylation (phosphorylation) of IL-1beta associated with pain, brush evoked pain, cancer pain and spontaneous pain
2) Confidence 0.61 Published 2010 Journal Brain Res. Section Abstract Doc Link 20478276 Disease Relevance 1.29 Pain Relevance 1.08

General Comments

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