INT168276

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Context Info
Confidence 0.19
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.30
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnf) extracellular space (Tnf) extracellular region (Tnf)
plasma membrane (Tnf) intracellular (Tnf) extracellular matrix organization (Tnf)
Tnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cancer pain 5 99.80 Very High Very High Very High
Spontaneous pain 2 99.32 Very High Very High Very High
Brush evoked pain 2 98.90 Very High Very High Very High
Stimulus evoked pain 1 86.88 High High
Spinal cord 2 82.44 Quite High
cytokine 2 80.68 Quite High
Hyperalgesia 1 72.88 Quite High
Neuropathic pain 1 72.44 Quite High
Inflammation 1 71.60 Quite High
Pain 1 41.52 Quite Low
Disease Link Frequency Relevance Heat
Cancer Pain 5 99.80 Very High Very High Very High
Pain 4 99.32 Very High Very High Very High
Neuropathic Pain 3 98.90 Very High Very High Very High
Cancer 3 87.36 High High
Hypersensitivity 1 86.48 High High
Hyperalgesia 1 72.88 Quite High
INFLAMMATION 1 71.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, a 3-day administration [4 microg/rat/day, intrathecally (i.t.)] of 4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole (SB203580), an inhibitor of p38MAPK, could suppress tactile allodynia and spontaneous pain of the bone cancer pain rats and decrease the phosphorylation of p38 as well as the expression of IL-1beta and TNF-alpha.
Negative_regulation (decrease) of Phosphorylation (phosphorylation) of TNF-alpha associated with pain, brush evoked pain, cancer pain and spontaneous pain
1) Confidence 0.19 Published 2010 Journal Brain Res. Section Abstract Doc Link 20478276 Disease Relevance 1.30 Pain Relevance 1.08

General Comments

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