INT168284

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Context Info
Confidence 0.78
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.10
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transporter activity (Slc22a8) plasma membrane (Slc22a8)
Slc22a8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
methotrexate 28 100.00 Very High Very High Very High
cINOD 4 99.10 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2 98.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Methotrexate has a clinically important pharmacokinetic interaction with nonsteroidal anti-inflammatory drugs (NSAIDs) mainly through its competition for tubular secretion via the renal organic anion transporter 3 (OAT3).
Localization (secretion) of OAT3 associated with inflammation, cinod and methotrexate
1) Confidence 0.78 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20478302 Disease Relevance 0.10 Pain Relevance 0.43
These results indicated that celecoxib inhibited the secretion of methotrexate via hOAT3, which suggested that celecoxib was a substrate of hOAT3.
Localization (secretion) of hOAT3 associated with methotrexate
2) Confidence 0.60 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20478302 Disease Relevance 0 Pain Relevance 0.39

General Comments

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