INT1683

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Context Info
Confidence 0.58
First Reported 1978
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 20
Total Number 26
Disease Relevance 6.29
Pain Relevance 3.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Cux1) Golgi apparatus (Cux1) nucleus (Cux1)
protein binding, bridging (Cux1) DNA binding (Cux1) cytoplasm (Cux1)
Anatomy Link Frequency
neurons 3
plasma 2
blood 2
pyramidal neurons 1
poly 1
Cux1 (Mus musculus)
Pain Link Frequency Relevance Heat
antinociception 8 99.92 Very High Very High Very High
addiction 18 99.70 Very High Very High Very High
Pyramidal cell 6 99.64 Very High Very High Very High
Eae 46 99.20 Very High Very High Very High
cerebral cortex 6 99.08 Very High Very High Very High
tail-flick 2 98.56 Very High Very High Very High
Inflammation 198 97.60 Very High Very High Very High
depression 2 97.20 Very High Very High Very High
Arthritis 187 95.92 Very High Very High Very High
Potency 57 95.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anxiety Disorder 123 99.56 Very High Very High Very High
Increased Venous Pressure Under Development 37 98.76 Very High Very High Very High
Pressure And Volume Under Development 121 98.20 Very High Very High Very High
INFLAMMATION 240 97.60 Very High Very High Very High
Depression 2 97.20 Very High Very High Very High
Arthritis 211 95.92 Very High Very High Very High
Overactive Bladder 61 95.76 Very High Very High Very High
Body Weight Changes 12 92.72 High High
Fever 168 91.92 High High
Stress 95 91.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In approx. 50% of subchronically reserpinized mice CDP produced a strong hypermotility, lasting for at least 1 hr.
Gene_expression (produced) of CDP
1) Confidence 0.58 Published 1978 Journal Pol J Pharmacol Pharm Section Abstract Doc Link 225733 Disease Relevance 0.10 Pain Relevance 0.43
For all samples, CDP and putative hydrolysis products were detected simultaneously by HPLC with UV detection at a wavelength of 254 nm (Spectroflow 757 Kratos Analytical).
Gene_expression (detected) of CDP
2) Confidence 0.54 Published 2010 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2813522 Disease Relevance 0 Pain Relevance 0
Another study in subjects suffering from anxiety disorder found a significant correlation between anxiety reduction and demoxepam plasma levels but not CDP plasma levels, suggesting that after chronic exposure, demoxepam may possess anxiolytic effects that surpass those of CDP itself (Lin and Friedel 1979).
Gene_expression (itself) of CDP in plasma associated with anxiety disorder
3) Confidence 0.54 Published 2010 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2813522 Disease Relevance 0.44 Pain Relevance 0.08
Interestingly, a study that found significant dependence after chronic CDP administration showed low CDP blood levels and high metabolite levels, indicating that demoxepam is indeed active (Chan et al. 1989).
Gene_expression (levels) of CDP in blood associated with addiction
4) Confidence 0.54 Published 2010 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2813522 Disease Relevance 0.43 Pain Relevance 0.10
To investigate the hydrolysis kinetics under various concentrations and environmental temperature conditions, the stability of a standard CDP solution was studied using a 10 ?
Gene_expression (solution) of CDP
5) Confidence 0.54 Published 2010 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2813522 Disease Relevance 0 Pain Relevance 0
Another study in subjects suffering from anxiety disorder found a significant correlation between anxiety reduction and demoxepam plasma levels but not CDP plasma levels, suggesting that after chronic exposure, demoxepam may possess anxiolytic effects that surpass those of CDP itself (Lin and Friedel 1979).
Gene_expression (those) of CDP in plasma associated with anxiety disorder
6) Confidence 0.54 Published 2010 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2813522 Disease Relevance 0.44 Pain Relevance 0.08
As the exact anxiolytic contributions of CDP and its active hydrolysis product demoxepam are hard to dissect and the ratio CDP/demoxepam is not stable over time in solution, we advise that chronic CDP applications in which CDP is dissolved should be interpreted with caution.
Gene_expression (dissolved) of CDP associated with anxiety disorder
7) Confidence 0.54 Published 2010 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2813522 Disease Relevance 0.28 Pain Relevance 0.09
Interestingly, a study that found significant dependence after chronic CDP administration showed low CDP blood levels and high metabolite levels, indicating that demoxepam is indeed active (Chan et al. 1989).
Gene_expression (administration) of CDP in blood associated with addiction
8) Confidence 0.54 Published 2010 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2813522 Disease Relevance 0.42 Pain Relevance 0.10
Chlordiazepoxide HCl (throughout the present study, CDP in the salt form was used) at a concentration of 2 mg/ml was kept for 40 days at a temperature of 37°C and subsequently stored at ?
Gene_expression (used) of CDP
9) Confidence 0.54 Published 2010 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2813522 Disease Relevance 0.19 Pain Relevance 0.03
As the exact anxiolytic contributions of CDP and its active hydrolysis product demoxepam are hard to dissect and the ratio CDP/demoxepam is not stable over time in solution, we advise that chronic CDP applications in which CDP is dissolved should be interpreted with caution.
Gene_expression (applications) of CDP associated with anxiety disorder
10) Confidence 0.54 Published 2010 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2813522 Disease Relevance 0.28 Pain Relevance 0.10
On PND8, a time point when the terminal differentiation of upper cortical layers is achieved in mice, neurons occupying layers II /III express CUX1, a homeodomain transcription factor (33, 34).
Gene_expression (express) of CUX1 in upper
11) Confidence 0.53 Published 2010 Journal mBio Section Body Doc Link PMC2953007 Disease Relevance 0.23 Pain Relevance 0.03
C) on the BrdU-labeled neurons destined to occupy the upper layers of the cerebral cortex, we measured BrdU incorporation into neurons expressing CUX1, a marker of cortical layers II/III (33, 34).
Gene_expression (expressing) of CUX1 in neurons associated with cerebral cortex
12) Confidence 0.53 Published 2010 Journal mBio Section Body Doc Link PMC2953007 Disease Relevance 0.24 Pain Relevance 0.22
DZ (1.25, 2.5 and 5 mg/kg), CDP (1.25, 2.5, 5, 10 and 20 mg/kg) and CZ (0.075, 0.3125, 0.625, 1.25 and 2.5 mg/kg) produced significant, dose-dependent (DZ, CDP) antinociception in mice.
Gene_expression (produced) of CDP associated with antinociception
13) Confidence 0.52 Published 2002 Journal Pol J Pharmacol Section Abstract Doc Link 12020041 Disease Relevance 0 Pain Relevance 0.55
DZ (1.25, 2.5 and 5 mg/kg), CDP (1.25, 2.5, 5, 10 and 20 mg/kg) and CZ (0.075, 0.3125, 0.625, 1.25 and 2.5 mg/kg) produced significant, dose-dependent (DZ, CDP) antinociception in mice.
Gene_expression (produced) of CDP associated with antinociception
14) Confidence 0.52 Published 2002 Journal Pol J Pharmacol Section Abstract Doc Link 12020041 Disease Relevance 0 Pain Relevance 0.54
Chlorodiazepoxide (CDP) produces stimulation of the locomotor activity of CD-1 and DBA/2 mice.
Gene_expression (produces) of CDP associated with eae
15) Confidence 0.52 Published 1978 Journal Pol J Pharmacol Pharm Section Abstract Doc Link 225733 Disease Relevance 0.06 Pain Relevance 0.34
BrdU-labeled, CUX1-labeled pyramidal neurons were reduced in the cerebral cortices of PND8 offspring of poly(I ? 
Gene_expression (labeled) of CUX1 in pyramidal neurons associated with pyramidal cell
16) Confidence 0.46 Published 2010 Journal mBio Section Body Doc Link PMC2953007 Disease Relevance 0.36 Pain Relevance 0.09
The decrease in the number of BrdU+ CUX1+ neurons in the progeny of mice treated with poly(I ? 
Gene_expression (neurons) of CUX1 in poly
17) Confidence 0.40 Published 2010 Journal mBio Section Body Doc Link PMC2953007 Disease Relevance 0.29 Pain Relevance 0.03
The percentage of CUX1+ neurons labeled with BrdU was reduced in offspring obtained from dams treated with poly(I ? 
Gene_expression (neurons) of CUX1 in neurons
18) Confidence 0.40 Published 2010 Journal mBio Section Body Doc Link PMC2953007 Disease Relevance 0.23 Pain Relevance 0.21
The mean fluorescent intensity of BrdU labeling was also reduced in CUX1+ neurons of these pups (4 pups obtained from 4 different dams) (P = 0.021 by the Mann-Whitney U test) (Fig. 5e).
Gene_expression (neurons) of CUX1 in neurons
19) Confidence 0.40 Published 2010 Journal mBio Section Body Doc Link PMC2953007 Disease Relevance 0.05 Pain Relevance 0.15
Synthesis of CDP-MP
Gene_expression (Synthesis) of CDP
20) Confidence 0.35 Published 2008 Journal International Journal of Nanomedicine Section Body Doc Link PMC2626937 Disease Relevance 0 Pain Relevance 0

General Comments

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