INT168304

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Context Info
Confidence 0.25
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 9.62
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SNRPB) nucleoplasm (SNRPB) mRNA processing (SNRPB)
nucleus (SNRPB) cytoplasm (SNRPB)
Anatomy Link Frequency
plasma 2
macrophages 1
fat 1
endothelial cells 1
lamina 1
SNRPB (Homo sapiens)
Pain Link Frequency Relevance Heat
Codeine 13 100.00 Very High Very High Very High
Inflammatory mediators 13 95.56 Very High Very High Very High
Angina 18 90.84 High High
Pain 7 87.92 High High
Morphine 1 80.00 Quite High
metalloproteinase 18 78.16 Quite High
methadone 5 75.00 Quite High
Inflammatory response 38 70.48 Quite High
antagonist 2 67.64 Quite High
agonist 4 67.04 Quite High
Disease Link Frequency Relevance Heat
Death 141 100.00 Very High Very High Very High
Acute Coronary Syndrome 36 99.76 Very High Very High Very High
Atherosclerosis 180 99.66 Very High Very High Very High
Lung Injury 19 99.60 Very High Very High Very High
Blister 84 99.56 Very High Very High Very High
Diabetes Mellitus 43 99.34 Very High Very High Very High
Hyperlipidemia 24 99.24 Very High Very High Very High
Injury 108 98.88 Very High Very High Very High
Hyperlipoproteinemia Type Ii 6 98.00 Very High Very High Very High
Emergencies 14 96.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of 13 recombinant UDP-glucuronosyltransferase (UGT) enzymes screened for COD glucuronidation activity, only UGT2B4 and UGT2B7 exhibited activity.
Positive_regulation (screened) of COD associated with codeine
1) Confidence 0.25 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20484152 Disease Relevance 0 Pain Relevance 0.91
The small number of controls with diabetes might explain the significantly elevated SM plasma concentrations in this subgroup.
Positive_regulation (elevated) of SM in plasma associated with diabetes mellitus
2) Confidence 0.23 Published 2006 Journal Nutr Metab (Lond) Section Body Doc Link PMC1360085 Disease Relevance 0.66 Pain Relevance 0.07
However, even in atherosclerotic lesions, the apparent rate of SM formation is relatively low compared with the rate of total phospholipid synthesis [12], suggesting that other factors might also contribute to intimal SM accumulation.
Positive_regulation (accumulation) of SM associated with atherosclerosis
3) Confidence 0.22 Published 2006 Journal Nutr Metab (Lond) Section Body Doc Link PMC1360085 Disease Relevance 0.91 Pain Relevance 0
Secondly, plasma SM levels are increased in human familial hyperlipidemias, especially in familial hypercholesterolemia [13], and also in animal models of atherosclerosis [14-16].
Positive_regulation (increased) of SM in plasma associated with atherosclerosis, hyperlipoproteinemia type ii and hyperlipidemia
4) Confidence 0.22 Published 2006 Journal Nutr Metab (Lond) Section Body Doc Link PMC1360085 Disease Relevance 0.99 Pain Relevance 0
However, in patients with acute coronary syndrome (n = 488), elevated SM was related to the combined endpoint (p < 0.05 by Log-rank test), also in a multivariate Cox regression analysis including potential confounders (HR 1.8, 95%CI 1.0–3.3, p < 0.05).


Positive_regulation (elevated) of SM associated with acute coronary syndrome
5) Confidence 0.22 Published 2006 Journal Nutr Metab (Lond) Section Abstract Doc Link PMC1360085 Disease Relevance 0.97 Pain Relevance 0.09
Additionally, it is a cost- and time-intensive process to derive the COD from the questionnaires because medical doctors or medically trained personnel need to review each form in order to assign diagnoses.
Positive_regulation (derive) of COD associated with death
6) Confidence 0.20 Published 2007 Journal Emerg Themes Epidemiol Section Body Doc Link PMC1904216 Disease Relevance 1.06 Pain Relevance 0.09
Moreover, atherosclerotic LDLs exhibit an increase in SM [9], which is believed to stimulate hydrolysis of LDL by secreted Smase.
Positive_regulation (increase) of SM associated with atherosclerosis
7) Confidence 0.19 Published 2006 Journal Nutr Metab (Lond) Section Body Doc Link PMC1360085 Disease Relevance 0.68 Pain Relevance 0
The SM concentration is also significantly increased in macrophages treated with acetyl-LDL plus an acyl-CoA:cholesterol acyltransferase inhibitor [11].
Positive_regulation (increased) of SM in macrophages
8) Confidence 0.19 Published 2006 Journal Nutr Metab (Lond) Section Body Doc Link PMC1360085 Disease Relevance 0.83 Pain Relevance 0
This divergence of SMC subtype differentiation programs and molecular mechanisms has been found to account for differential SM–major histocompatibility complex and CRP-1 (also known as CEBPE) activation in various SMC subtypes [78,79].
Positive_regulation (activation) of SM
9) Confidence 0.03 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 0.44 Pain Relevance 0.04
The unusually high level of expression of these proteins in uterine SMCs, however, suggests not only that there are quantitative differences in the force-generating apparatus and the contractile capacities among different SMCs but also that these differences may reflect the distinct mechanical requirements of each SM cell type.
Positive_regulation (requirements) of SM in uterine
10) Confidence 0.03 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 0.05 Pain Relevance 0.07
BPA immunoreactivity is diminished in SM-exposed guinea pig skin.81 BP180 is a transmembrane protein with a collagenous carboxyl-terminal extracellular domain.82 Immunoelectron microscopic studies demonstrated that the C-terminal part of BP180 actually reaches into the lamina densa.83 Immunhistochemical studies revealed that BP180 was present in both the epidermis (blister roof) and dermis (blister ground) of mice skin following SM exposure.80 This supports in part the findings of earlier studies that described intact hemidesmosomal components and attached anchoring filaments to be forming the roof of the blister and the lamina densa its base.76
Positive_regulation (following) of SM in lamina associated with blister
11) Confidence 0.02 Published 2008 Journal Eplasty Section Body Doc Link PMC2431646 Disease Relevance 0.79 Pain Relevance 0.10
The finding that other vesicant substances inhibit hexokinase substantiated the SM data.
Positive_regulation (substantiated) of SM
12) Confidence 0.02 Published 2008 Journal Eplasty Section Body Doc Link PMC2431646 Disease Relevance 0 Pain Relevance 0
A concentration-dependent increase of SM-mediated cytotoxic effects with high affection of endothelial cells could be demonstrated.45

Therapeutic approaches—the road ahead

Positive_regulation (increase) of SM in endothelial cells
13) Confidence 0.02 Published 2008 Journal Eplasty Section Body Doc Link PMC2431646 Disease Relevance 0.77 Pain Relevance 0.08
= 3.59 hours, volume of distribution at steady state (Vdss 74.4 L.13 However, a high-distribution volume indicates accumulation of SM in fatty organs or fat depots.
Positive_regulation (accumulation) of SM in fat
14) Confidence 0.02 Published 2008 Journal Eplasty Section Body Doc Link PMC2431646 Disease Relevance 0.15 Pain Relevance 0
With increasing SM concentration cellular responses consists of cell cycle arrest, terminal differentiation, apoptosis, or necrosis.57 SM-injured cells are arrested at certain cell cycle checkpoints.
Positive_regulation (increasing) of SM associated with necrosis and apoptosis
15) Confidence 0.02 Published 2008 Journal Eplasty Section Body Doc Link PMC2431646 Disease Relevance 0.55 Pain Relevance 0
Meanwhile, treatment with the MMP-inhibitor doxycycline attenuated lung injury.88 In the eye, MMP activation after SM exposure could also be shown and pathologic effects could be ameliorated with the MMP inhibitor Ilomastat.90

Inflammatory mediators and cellular infiltrate

Positive_regulation (activation) of SM in lung associated with lung injury and inflammatory mediators
16) Confidence 0.02 Published 2008 Journal Eplasty Section Body Doc Link PMC2431646 Disease Relevance 0.43 Pain Relevance 0.17
The unchanged expression of NGAL protein after long-term SM induction was however not parallel by increased mRNA expression.
Positive_regulation (induction) of SM
17) Confidence 0.01 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2873661 Disease Relevance 0.34 Pain Relevance 0.03

General Comments

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