INT168323

Context Info Confidence 0.15 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Title Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.56

Gsta5 (Rattus norvegicus)

Pain Link Frequency Relevance Heat MU agonist 1 97.64 Oxycodone 4 97.16 Opioid 1 92.80

|}

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Repeated administration of oxycodone modifies the gene expression of several drug metabolising enzymes in the hepatic tissue of male Sprague-Dawley rats, including glutathione S-transferase A-5 (rGSTA5) and CYP3A2.

Positive_regulation (transferase) of Gene_expression (transferase) of rGSTA5 associated with oxycodone

1) Confidence 0.15 Published 2010 Journal J. Pharm. Pharmacol. Section Title Doc Link 20487198 Disease Relevance 0 Pain Relevance 0.56

General Comments

This test has worked.