INT168325

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Context Info
Confidence 0.20
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Gsta5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Oxycodone 12 99.62 Very High Very High Very High
MU agonist 3 97.64 Very High Very High Very High
Opioid 3 92.80 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Repeated administration of oxycodone modifies the gene expression of several drug metabolising enzymes in the hepatic tissue of male Sprague-Dawley rats, including glutathione S-transferase A-5 (rGSTA5) and CYP3A2.
Gene_expression (transferase) of rGSTA5 associated with oxycodone
1) Confidence 0.20 Published 2010 Journal J. Pharm. Pharmacol. Section Title Doc Link 20487198 Disease Relevance 0 Pain Relevance 0.56
Repeated administration of oxycodone modifies the gene expression of several drug metabolising enzymes in the hepatic tissue of male Sprague-Dawley rats, including glutathione S-transferase A-5 (rGSTA5) and CYP3A2.
Gene_expression (expression) of rGSTA5 associated with oxycodone
2) Confidence 0.20 Published 2010 Journal J. Pharm. Pharmacol. Section Title Doc Link 20487198 Disease Relevance 0 Pain Relevance 0.56
KEY FINDINGS: The expression of several drug metabolising enzymes was modulated by oxycodone treatment: cytochrome P450 (CYP) 2B2, CYP2C13, CYP17A1, epoxide hydrolase 2, carboxylesterase 2, flavin-containing monooxygenase 1, glutathione S-transferase alpha 5 (rGSTA5) and CYP3A2.
Gene_expression (expression) of rGSTA5
3) Confidence 0.18 Published 2010 Journal J. Pharm. Pharmacol. Section Body Doc Link 20487198 Disease Relevance 0 Pain Relevance 0

General Comments

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