INT168327

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Olr1746)
Olr1746 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
MU agonist 1 97.32 Very High Very High Very High
Oxycodone 4 97.16 Very High Very High Very High
Nucleus accumbens 6 94.00 High High
Opioid 1 92.48 High High
Somatosensory cortex 6 88.36 High High
Hippocampus 24 75.20 Quite High
amygdala 3 47.36 Quite Low
Pyramidal cell 11 24.28 Low Low
Anterior cingulate 3 21.40 Low Low
halothane 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 6 25.84 Quite Low
Hypersensitivity 2 5.00 Very Low Very Low Very Low
Depression 1 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In situ hybridization results indicate that TRPC4 or 5 mRNA is highly expressed in the LS and PFC.
Positive_regulation (highly) of Gene_expression (expressed) of or 5
1) Confidence 0.45 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0 Pain Relevance 0.19
Repeated administration of oxycodone modifies the gene expression of several drug metabolising enzymes in the hepatic tissue of male Sprague-Dawley rats, including glutathione S-transferase A-5 (rGSTA5) and CYP3A2.
Positive_regulation (transferase) of Gene_expression (transferase) of A-5 associated with oxycodone
2) Confidence 0.04 Published 2010 Journal J. Pharm. Pharmacol. Section Title Doc Link 20487198 Disease Relevance 0 Pain Relevance 0.56

General Comments

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