INT168327

Context Info Confidence 0.45 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Title Documents 2 Total Number 2 Disease Relevance 0 Pain Relevance 0.75

signal transducer activity (Olr1746)

Olr1746 (Rattus norvegicus)

Pain Link Frequency Relevance Heat MU agonist 1 97.32 Oxycodone 4 97.16 Nucleus accumbens 6 94.00 Opioid 1 92.48 Somatosensory cortex 6 88.36 Hippocampus 24 75.20 amygdala 3 47.36 Pyramidal cell 11 24.28 Anterior cingulate 3 21.40 halothane 3 5.00

Disease Link Frequency Relevance Heat Urological Neuroanatomy 6 25.84 Hypersensitivity 2 5.00 Depression 1 5.00 Death 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In situ hybridization results indicate that TRPC4 or 5 mRNA is highly expressed in the LS and PFC.

Positive_regulation (highly) of Gene_expression (expressed) of or 5

1) Confidence 0.45 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0 Pain Relevance 0.19

Repeated administration of oxycodone modifies the gene expression of several drug metabolising enzymes in the hepatic tissue of male Sprague-Dawley rats, including glutathione S-transferase A-5 (rGSTA5) and CYP3A2.

Positive_regulation (transferase) of Gene_expression (transferase) of A-5 associated with oxycodone

2) Confidence 0.04 Published 2010 Journal J. Pharm. Pharmacol. Section Title Doc Link 20487198 Disease Relevance 0 Pain Relevance 0.56

General Comments

This test has worked.