INT168328

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.79
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp3a2) endoplasmic reticulum (Cyp3a2) enzyme binding (Cyp3a2)
cytoplasm (Cyp3a2)
Cyp3a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 2 81.92 Quite High
Inflammation 2 58.52 Quite High
Oxycodone 4 50.00 Quite Low
cytokine 2 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
MU agonist 1 5.00 Very Low Very Low Very Low
Opioid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Viral Infection 4 99.98 Very High Very High Very High
Adenovirus Infection 14 96.00 Very High Very High Very High
Infection 20 93.48 High High
Lower Respiratory Tract Infection 2 88.96 High High
Toxicity 8 87.88 High High
INFLAMMATION 6 81.60 Quite High
Adverse Drug Reaction 2 64.60 Quite High
Pulmonary Disease 2 30.44 Quite Low
Asthma 2 30.08 Quite Low
Hepatotoxicity 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: Repeated oxycodone administration is associated with a significant up-regulation of rGSTA5 and concomitant down-regulation of CYP3A2 mRNA, protein expression and functionality.
Regulation (regulation) of Gene_expression (expression) of CYP3A2
1) Confidence 0.45 Published 2010 Journal J. Pharm. Pharmacol. Section Body Doc Link 20487198 Disease Relevance 0 Pain Relevance 0
Recombinant adenoviruses were chosen as model pathogens to further define processes by which viral infection alters expression of CYP3A2 and 2C11 for several reasons.
Regulation (alters) of Gene_expression (expression) of CYP3A2 associated with viral infection
2) Confidence 0.38 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.70 Pain Relevance 0.07
Effect of administration of recombinant adenoviruses on hepatic CYP3A2 expression and function
Regulation (Effect) of Gene_expression (expression) of CYP3A2
3) Confidence 0.23 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.09 Pain Relevance 0

General Comments

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