INT168367

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Context Info
Confidence 0.71
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.60
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp2e1) oxidoreductase activity (Cyp2e1) endoplasmic reticulum (Cyp2e1)
enzyme binding (Cyp2e1)
Anatomy Link Frequency
liver 1
Cyp2e1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
halothane 60 99.66 Very High Very High Very High
Inflammatory response 7 97.68 Very High Very High Very High
alcohol 21 95.96 Very High Very High Very High
anesthesia 4 94.72 High High
Paracetamol 1 94.52 High High
cytokine 5 76.56 Quite High
Inflammation 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 15 97.32 Very High Very High Very High
Injury 10 83.80 Quite High
Necrosis 9 77.16 Quite High
Cancer 3 76.80 Quite High
Cardiovascular Disease 3 68.08 Quite High
Anxiety Disorder 1 53.60 Quite High
Death 13 5.00 Very Low Very Low Very Low
Apoptosis 5 5.00 Very Low Very Low Very Low
Heart Disease 1 5.00 Very Low Very Low Very Low
Immunization 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Collectively, BF has inducing potential of liver CYP1A2 and CYP2E1 and may influence the corresponding pharmacokinetics of other drugs.
Localization (potential) of CYP2E1 in liver
1) Confidence 0.71 Published 2010 Journal J Asian Nat Prod Res Section Abstract Doc Link 20496194 Disease Relevance 0.05 Pain Relevance 0.09
Also of interest is that both halothane and ethanol are metabolized through cytochrome P450 2E1 (CYP2E1) [12], possible providing a shared mechanism.
Localization (metabolized) of CYP2E1 associated with halothane
2) Confidence 0.48 Published 2005 Journal BMC Anesthesiol Section Body Doc Link PMC1090549 Disease Relevance 0.55 Pain Relevance 0.63

General Comments

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