INT168379

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Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.79
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp3) extracellular space (Mmp3) extracellular region (Mmp3)
proteinaceous extracellular matrix (Mmp3) nucleus (Mmp3) protein complex (Mmp3)
Anatomy Link Frequency
amniotic cavity 4
osteoclast 2
Mmp3 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 44 73.04 Quite High
Inflammation 16 54.80 Quite High
cytokine 12 53.76 Quite High
antagonist 18 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Dismenorea 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rupture 12 95.64 Very High Very High Very High
Infection 70 86.12 High High
Low Back Pain 1 83.32 Quite High
Targeted Disruption 1 81.04 Quite High
Necrosis 4 80.32 Quite High
Cancer 6 79.96 Quite High
Sacroiliitis 2 79.32 Quite High
Premature Birth 80 70.28 Quite High
INFLAMMATION 22 54.80 Quite High
Pre-term Labor 26 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Severe, erosive bilateral sacroiliitis in 14-week-old hTNFtg animals was accompanied by an upregulation of mRNAs related to tissue inflammation such as matrix metalloproteinase 3 (MMP3), MMP9 and MMP13 or osteoclast activation such as cathepsin K and tartrate-resistant acid phosphatase.
Positive_regulation (upregulation) of Positive_regulation (upregulation) of MMP3 in osteoclast
1) Confidence 0.42 Published 2010 Journal Ann. Rheum. Dis. Section Body Doc Link 20498200 Disease Relevance 0.40 Pain Relevance 0
In a cross-sectional study involving 365 subjects and conducted by Park et al. [45], increased levels of MMP-3 were associated with parturition, both term and preterm, as wells as microbial invasion of the amniotic cavity.
Positive_regulation (levels) of Positive_regulation (increased) of MMP-3 in amniotic cavity
2) Confidence 0.07 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.69 Pain Relevance 0.15
In a cross-sectional study involving 365 subjects and conducted by Park et al. [45], increased levels of MMP-3 were associated with parturition, both term and preterm, as wells as microbial invasion of the amniotic cavity.
Positive_regulation (increased) of Positive_regulation (levels) of MMP-3 in amniotic cavity
3) Confidence 0.07 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.69 Pain Relevance 0.15

General Comments

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