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Context Info
Confidence 0.49
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.48
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp13) extracellular space (Mmp13) extracellular region (Mmp13)
Golgi apparatus (Mmp13) proteinaceous extracellular matrix (Mmp13) lysosome (Mmp13)
Anatomy Link Frequency
osteoclast 2
Mmp13 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 12 99.36 Very High Very High Very High
Inflammation 17 71.76 Quite High
Osteoarthritis 141 50.00 Quite Low
Pain 39 5.00 Very Low Very Low Very Low
diclofenac 13 5.00 Very Low Very Low Very Low
cINOD 9 5.00 Very Low Very Low Very Low
Analgesic 3 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
Onset of action 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Low Back Pain 2 83.32 Quite High
Targeted Disruption 1 81.04 Quite High
Necrosis 4 80.32 Quite High
Cancer 4 79.96 Quite High
Sacroiliitis 2 79.32 Quite High
INFLAMMATION 19 71.76 Quite High
Osteoarthritis 143 50.00 Quite Low
Sclerosis 1 39.28 Quite Low
Pain 38 5.00 Very Low Very Low Very Low
Disease 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-induced increase in collagenase activity, but only A1S2 inhibited the spontaneous collagenase activity.
Positive_regulation (induced) of Positive_regulation (increase) of collagenase
1) Confidence 0.49 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779427 Disease Relevance 0.07 Pain Relevance 0.22
RESULTS: Severe, erosive bilateral sacroiliitis in 14-week-old hTNFtg animals was accompanied by an upregulation of mRNAs related to tissue inflammation such as matrix metalloproteinase 3 (MMP3), MMP9 and MMP13 or osteoclast activation such as cathepsin K and tartrate-resistant acid phosphatase.
Positive_regulation (upregulation) of Positive_regulation (activation) of MMP13 in osteoclast
2) Confidence 0.31 Published 2010 Journal Ann. Rheum. Dis. Section Body Doc Link 20498200 Disease Relevance 0.40 Pain Relevance 0

General Comments

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