INT168381

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Context Info
Confidence 0.58
First Reported 2004
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 24
Total Number 24
Disease Relevance 19.12
Pain Relevance 7.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp3) extracellular space (Mmp3) extracellular region (Mmp3)
proteinaceous extracellular matrix (Mmp3) nucleus (Mmp3) protein complex (Mmp3)
Anatomy Link Frequency
plasma 2
amniotic cavity 2
osteoclast 2
synovial fluid 1
molecular layer 1
Mmp3 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 475 100.00 Very High Very High Very High
rheumatoid arthritis 427 99.48 Very High Very High Very High
cva 22 99.40 Very High Very High Very High
Arthritis 393 98.48 Very High Very High Very High
Hippocampus 6 98.20 Very High Very High Very High
Inflammation 423 96.08 Very High Very High Very High
chemokine 22 95.12 Very High Very High Very High
cytokine 159 94.72 High High
ischemia 18 94.16 High High
Central nervous system 14 92.16 High High
Disease Link Frequency Relevance Heat
Disease 244 99.82 Very High Very High Very High
Rheumatoid Arthritis 427 99.48 Very High Very High Very High
Abdominal Aortic Aneurysm 9 99.40 Very High Very High Very High
Fibrosis 110 99.28 Very High Very High Very High
Autoimmune Disease 32 98.92 Very High Very High Very High
Convulsion 3 98.76 Very High Very High Very High
Arthritis 417 98.48 Very High Very High Very High
Rupture 23 98.48 Very High Very High Very High
Coronary Aneurysm 48 98.32 Very High Very High Very High
Aneurism 65 98.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Severe, erosive bilateral sacroiliitis in 14-week-old hTNFtg animals was accompanied by an upregulation of mRNAs related to tissue inflammation such as matrix metalloproteinase 3 (MMP3), MMP9 and MMP13 or osteoclast activation such as cathepsin K and tartrate-resistant acid phosphatase.
Positive_regulation (upregulation) of MMP3 in osteoclast
1) Confidence 0.58 Published 2010 Journal Ann. Rheum. Dis. Section Body Doc Link 20498200 Disease Relevance 0.40 Pain Relevance 0
This is in line with previous reports that demonstrated elevated MMP-3 expression levels in synovial fluids and sera of patients with rheumatoid arthritis as well as expression in joints of CIA rats [10-12].
Positive_regulation (elevated) of MMP-3 in joints associated with rheumatoid arthritis, metalloproteinase and arthritis
2) Confidence 0.55 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945063 Disease Relevance 1.21 Pain Relevance 0.74
We found that rosiglitazone caused significant upregulation of Mmp3, which encodes the matrix metalloproteinase stromelysin.
Positive_regulation (upregulation) of Mmp3 associated with metalloproteinase
3) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481284 Disease Relevance 0.99 Pain Relevance 0.20
It is therefore possible that the in vivo upregulation of Mmp3 by rosiglitazone will promote plaque rupture, leading to increased rates of myocardial infarction, as well as increasing tissue remodeling after ischemia.
Positive_regulation (upregulation) of Mmp3 in plaque associated with rupture, ischemia and myocardial infarction
4) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481284 Disease Relevance 0.99 Pain Relevance 0.21
In rodents, MMP-2, MMP-3, MMP-9, MMP-13, MMP-14, as well as TIMP-1 and TIMP-2 are expressed in early stages of HSC activation and have been implicated in fibrogenesis as well as fibrolysis (reviewed in [20]).
Positive_regulation (activation) of MMP-3 associated with fibrosis
5) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.89 Pain Relevance 0.31
In fibrotic animals, hepatic expression of MMP-2, MMP-3, MMP-8, MMP-9 and MMP-13 mRNA were all significantly upregulated, compared to non-fibrotic controls (Figure 6).
Positive_regulation (upregulated) of MMP-3 associated with fibrosis
6) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.33 Pain Relevance 0.06
In our study, it appears that elevated MMP-3 activity may represent a risk factor for coronary aneurysm formation.
Positive_regulation (elevated) of MMP-3 associated with coronary aneurysm
7) Confidence 0.41 Published 2004 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC526392 Disease Relevance 1.22 Pain Relevance 0.10
Because elevated MMP-3 levels likely contribute to the development of coronary aneurysms, this matrix-degrading enzyme may represent an important therapeutic target.
Positive_regulation (elevated) of MMP-3 associated with coronary aneurysm
8) Confidence 0.41 Published 2004 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC526392 Disease Relevance 0.97 Pain Relevance 0.35
RESULTS: Severe, erosive bilateral sacroiliitis in 14-week-old hTNFtg animals was accompanied by an upregulation of mRNAs related to tissue inflammation such as matrix metalloproteinase 3 (MMP3), MMP9 and MMP13 or osteoclast activation such as cathepsin K and tartrate-resistant acid phosphatase.
Positive_regulation (upregulation) of matrix metalloproteinase 3 in osteoclast
9) Confidence 0.34 Published 2010 Journal Ann. Rheum. Dis. Section Body Doc Link 20498200 Disease Relevance 0.40 Pain Relevance 0
Increased levels of MMP-2, MMP-3, MMP-9 and MMP-12 have been identified in aneurysm vessel walls [23-27].
Positive_regulation (Increased) of MMP-3 associated with aneurism
10) Confidence 0.28 Published 2004 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC526392 Disease Relevance 0.72 Pain Relevance 0.26
We detected significant plasma elevations of only IL-6, G-CSF, and MMP-3 at day 8 (peak disease) in the mouse CAIA model when compared with naïve animals (Figure 4b to 4d).
Positive_regulation (elevations) of MMP-3 in plasma associated with disease and arthritis
11) Confidence 0.25 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911895 Disease Relevance 0.67 Pain Relevance 0.35
In contrast, disease-related increases in plasma MMP-3 were decreased ~50% by all treatments with minimal statistical significance.
Positive_regulation (increases) of MMP-3 in plasma associated with disease
12) Confidence 0.19 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911895 Disease Relevance 0.84 Pain Relevance 0.42
For example, proteins contributing to angiogenesis (VEGFR1), extracellular matrix remodeling (MMP-2 and MMP-3) were not upregulated in ischemic/reperfused muscles as compared to myotoxin injured muscles, whereas some factors regulating the activation and migration of leukocytes in injured tissues (MIP-1, MIP-2 and MIP-3) and inflammation (sTNF R1 and sTNF R2) were increased in ischemic/reperfused muscles (Table 1).
Neg (not) Positive_regulation (upregulated) of MMP-3 in extracellular matrix associated with inflammation
13) Confidence 0.16 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2866363 Disease Relevance 0.31 Pain Relevance 0.17
In addition to improving clinical outcomes measurements as determined by the American College of Rheumatology (ACR) criteria as early as 1 week after oral administration, R406 also reduced the level of serum IL-6 and MMP-3 (stromelysin-1) in the groups receiving 100?
Positive_regulation (serum) of stromelysin-1
14) Confidence 0.15 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.85 Pain Relevance 0.37
In terms of autoimmune disease several metalloproteinases including ADAM-17, MMP-9, MMP-3, MMP-2, or MMP-8 are reportedly increased in the serum or peripheral leukocytes of patients with systemic sclerosis, system lupus erythematosus, and Wegener's granulomatosis [106–109].
Positive_regulation (increased) of MMP-3 in leukocytes associated with autoimmune disease, metalloproteinase, systemic lupus erythematosus and systemic sclerosis
15) Confidence 0.12 Published 2010 Journal Hepatitis Research and Treatment Section Body Doc Link PMC3021850 Disease Relevance 1.37 Pain Relevance 0.53
Consistent with our finding in RA FLS monocultures, we found that BACE/RA FLS co-cultures produced negligible MMP-3 in response to IFN-?
Positive_regulation (negligible) of MMP-3 associated with metalloproteinase and rheumatoid arthritis
16) Confidence 0.11 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888198 Disease Relevance 0.98 Pain Relevance 0.66
induced RA FLS protease production we measured MMP-3 levels in supernatant at the 72-hour endpoint for our experiments.
Positive_regulation (measured) of MMP-3 associated with metalloproteinase and rheumatoid arthritis
17) Confidence 0.11 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888198 Disease Relevance 0.78 Pain Relevance 0.57
In a cross-sectional study involving 365 subjects and conducted by Park et al. [45], increased levels of MMP-3 were associated with parturition, both term and preterm, as wells as microbial invasion of the amniotic cavity.
Positive_regulation (increased) of MMP-3 in amniotic cavity
18) Confidence 0.10 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.69 Pain Relevance 0.15
MMP-3 concentrations were elevated in the molecular layer of the dentate after traumatic brain injury [29].
Positive_regulation (elevated) of MMP-3 in molecular layer associated with brain injury
19) Confidence 0.09 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1199600 Disease Relevance 0.35 Pain Relevance 0.30
In a cross-sectional study involving 365 subjects and conducted by Park et al. [45], increased levels of MMP-3 were associated with parturition, both term and preterm, as wells as microbial invasion of the amniotic cavity.
Positive_regulation (levels) of MMP-3 in amniotic cavity
20) Confidence 0.07 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.69 Pain Relevance 0.15

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