INT168395

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Context Info
Confidence 0.51
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.50
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cyp19a1) oxidoreductase activity (Cyp19a1) endoplasmic reticulum (Cyp19a1)
cytoplasm (Cyp19a1)
Anatomy Link Frequency
NOS1 1
proximal 1
Cyp19a1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 8 100.00 Very High Very High Very High
Spinal cord 1 100.00 Very High Very High Very High
Neuropathic pain 5 90.16 High High
Enkephalin 1 82.00 Quite High
Sciatic nerve 1 79.60 Quite High
Antihyperalgesic 2 75.00 Quite High
antiallodynic 2 75.00 Quite High
Cannabinoid 2 75.00 Quite High
Opioid 1 75.00 Quite High
agonist 2 59.12 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 40 100.00 Very High Very High Very High
Breast Cancer 100 98.60 Very High Very High Very High
Cancer 132 92.40 High High
Neuropathic Pain 5 90.16 High High
Nervous System Injury 1 76.48 Quite High
Metastasis 4 75.96 Quite High
Intestinal Cancer 6 55.56 Quite High
Apoptosis 6 51.72 Quite High
INFLAMMATION 22 50.00 Quite Low
Obesity 2 46.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At least two PGE2 receptor (EP) isoforms signal by increasing adenylate cyclase activity [61], and CYP19 is transcribed from cAMP-responsive promoters in breast tumor-proximal stromal tissue.
Transcription (transcribed) of CYP19 in proximal associated with breast cancer
1) Confidence 0.51 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206709 Disease Relevance 0.77 Pain Relevance 0
These correlations are thought to reflect a causal link, because PG signaling can stimulate transcription of the CYP19 gene [55-60].
Transcription (transcription) of CYP19
2) Confidence 0.51 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206709 Disease Relevance 0.84 Pain Relevance 0
Expression of DOPr and CB2R mRNA in the spinal cord and dorsal root ganglia of naive and nerve-injured WT, NOS1-knockout (KO), and NOS2-KO mice, also was assessed.
Transcription (Expression) of KO in NOS1 associated with targeted disruption, opioid receptor and spinal cord
3) Confidence 0.07 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20498253 Disease Relevance 0.89 Pain Relevance 1.06

General Comments

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