INT168397

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.77
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cyp19a1) oxidoreductase activity (Cyp19a1) endoplasmic reticulum (Cyp19a1)
cytoplasm (Cyp19a1)
Anatomy Link Frequency
NOS1 1
bone tissue 1
Cyp19a1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 8 100.00 Very High Very High Very High
Spinal cord 3 100.00 Very High Very High Very High
Neuropathic pain 5 89.04 High High
Enkephalin 1 82.00 Quite High
Sciatic nerve 1 79.60 Quite High
Antihyperalgesic 2 75.00 Quite High
antiallodynic 2 75.00 Quite High
Cannabinoid 2 75.00 Quite High
Opioid 1 75.00 Quite High
agonist 2 59.12 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 33 100.00 Very High Very High Very High
Neuropathic Pain 5 89.04 High High
Reprotox - General 1 28 85.92 High High
Nervous System Injury 1 75.36 Quite High
Sprains And Strains 15 74.36 Quite High
Aging 1 40.72 Quite Low
Hydrocephalus 8 36.48 Quite Low
Appetite Loss 2 34.92 Quite Low
Starvation 1 29.84 Quite Low
Body Weight 2 27.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of DOPr and CB2R mRNA in the spinal cord and dorsal root ganglia of naive and nerve-injured WT, NOS1-knockout (KO), and NOS2-KO mice, also was assessed.
Gene_expression (Expression) of KO in NOS1 associated with targeted disruption, opioid receptor and spinal cord
1) Confidence 0.06 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20498253 Disease Relevance 0.88 Pain Relevance 1.06
Androgens derived from residual steroidogenesis may act directly on androgen receptors previously identified in bone tissue [26] or be converted to estrogens by aromatase expressed in bone [27–30] before acting on bone cells to protect against accelerated bone loss.
Gene_expression (expressed) of aromatase in bone tissue
2) Confidence 0.03 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951122 Disease Relevance 0.29 Pain Relevance 0
Thus it is possible that either the addition of the lacZ coding region or differences in the amount of intron sequence deleted between the two KO alleles could affect either the expression of adjacent genes or possible expression of downstream exons of either Nfix KO allele.
Spec (possible) Gene_expression (expression) of KO allele associated with targeted disruption
3) Confidence 0.01 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2414869 Disease Relevance 0.59 Pain Relevance 0

General Comments

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