INT168399

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Context Info
Confidence 0.81
First Reported 2005
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 12
Total Number 16
Disease Relevance 4.37
Pain Relevance 6.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cnr2) plasma membrane (Cnr2) signal transducer activity (Cnr2)
Anatomy Link Frequency
brain 3
microglial cells 2
NOS1 1
immune system 1
keratinocytes 1
Cnr2 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 34 99.92 Very High Very High Very High
Cannabinoid receptor 47 99.90 Very High Very High Very High
depression 295 99.40 Very High Very High Very High
agonist 264 99.32 Very High Very High Very High
Central nervous system 52 99.18 Very High Very High Very High
antagonist 167 99.08 Very High Very High Very High
drug abuse 89 98.80 Very High Very High Very High
Endocannabinoid 35 98.40 Very High Very High Very High
Neuropathic pain 141 95.96 Very High Very High Very High
alcohol 206 91.44 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 55 100.00 Very High Very High Very High
Nervous System Injury 20 100.00 Very High Very High Very High
Depression 300 99.40 Very High Very High Very High
Drug Dependence 116 98.80 Very High Very High Very High
Neuropathic Pain 179 95.96 Very High Very High Very High
Obesity 3 95.16 Very High Very High Very High
Pain 193 86.64 High High
Stress 260 86.24 High High
INFLAMMATION 108 77.96 Quite High
Neuralgia 2 63.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Subcellular localization of CB2-Rs in the rodent brain
Localization (localization) of CB2 in brain
1) Confidence 0.81 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.52 Pain Relevance 0.54
The pattern of staining in most hippocampal areas appears to be mainly post-synaptic localization of CB2-Rs.
Localization (localization) of CB2
2) Confidence 0.81 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0 Pain Relevance 0.07
The functional implication of pre- and/or post-synaptic localization of CB2-Rs awaits further electrophysiological investigation and image analysis of this interesting component of the EPCS.
Localization (localization) of CB2
3) Confidence 0.81 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.18 Pain Relevance 0.21
As definitive electron microscopic evidence is needed to precisely determine the subcellular localization of CB2-Rs, our transmission electron micrograph data using immunoelectron microscopy approach shows a high-resolution definition of hippocampal CB2-R localization at the ultrastructural level.
Spec (determine) Localization (localization) of CB2-R
4) Confidence 0.81 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.06 Pain Relevance 0
As definitive electron microscopic evidence is needed to precisely determine the subcellular localization of CB2-Rs, our transmission electron micrograph data using immunoelectron microscopy approach shows a high-resolution definition of hippocampal CB2-R localization at the ultrastructural level.
Spec (determine) Localization (localization) of CB2
5) Confidence 0.81 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.06 Pain Relevance 0
We performed an immunoelectron microscopy study to determine the subcellular localization of CB2-R in the selected rodent brain structures that we have shown contain CB2-R immunoreactivity [23].
Spec (determine) Localization (localization) of CB2-R in brain structures
6) Confidence 0.81 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.39 Pain Relevance 0.54
We report for the using electron microscopy the sub cellular localization of CB2-Rs that are mainly on post-synaptic elements in rodent brain.


Localization (localization) of CB2 in brain
7) Confidence 0.71 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2241668 Disease Relevance 0.37 Pain Relevance 0.46
As definitive electron microscopic evidence is needed to precisely determine the subcellular localization of CB2-Rs, our transmission electron micrograph data using immunoelectron microscopy approach shows a high-resolution definition of hippocampal CB2-R localization at the ultrastructural level.
Localization (localization) of CB2-R
8) Confidence 0.71 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.06 Pain Relevance 0
Subsequently, these membranes were first hybridized with the goat anti-CB2 antibody (1:100 dilution; Santa Cruz) for 2 hr and then washed 3 times in TBS and immunoblotting using an anti-goat HRP-conjugated IgG secondary antibody as a tracer (Pierce Biotechnology, Inc.
Localization (antibody) of CB2
9) Confidence 0.68 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0.05 Pain Relevance 0
Although endocannabinoids, including anandamide and 2-arachidonoylglycerol (2-AG) [26], act upon CB1 and CB2 receptors are secreted by neurons, they are more prominently produced in microglial cells during neuroinflammatory conditions. 2-AG promotes recruitment of microglial cells by ligation of CB2, but not CB1 receptors [26].
Localization (secreted) of CB2 in microglial cells associated with endocannabinoid
10) Confidence 0.64 Published 2010 Journal Mol Pain Section Body Doc Link PMC2845559 Disease Relevance 0.31 Pain Relevance 0.47
Microglial cells express CB2
Localization (Microglial cells) of CB2 in Microglial cells
11) Confidence 0.59 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0 Pain Relevance 0.07
Moreover, although the basal levels of DOPr and CB2R mRNA were similar between WT and NOS-KO animals, nerve injury only decreased (DOPr) or increased (CB2R) their expression in the dorsal root ganglia of WT and NOS2-KO mice, and not in NOS1-KO mice.
Localization (decreased) of CB2R in NOS1 associated with targeted disruption, nervous system injury and opioid receptor
12) Confidence 0.45 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20498253 Disease Relevance 0.89 Pain Relevance 0.97
The inhibition of IL-2 expression by 2-AG and noladin ether is independently of CB1/CB2, since similar suppression of IL-2 by 2-AG and noladin ether was observed in splenocytes derived from CB1/CB2-null mice and CB1/CB2 antagonists failed to block inhibition of IL-2 by 2-AG. 2-AG and noladin ether increased PPAR?
Localization (derived) of CB2 associated with antagonist
13) Confidence 0.38 Published 2007 Journal PPAR Research Section Body Doc Link PMC2220031 Disease Relevance 0.16 Pain Relevance 0.23
CB1 receptors are widely distributed in the central nervous system and peripheral sensory neurons, whereas CB2 receptors have been found in peripheral tissues including tissues of the immune system and keratinocytes with limited expression in sensory and central nervous system cells.58
Localization (receptors) of CB2 in immune system associated with central nervous system
14) Confidence 0.16 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004649 Disease Relevance 0.61 Pain Relevance 1.41
THC is an agonist of the cannabinoid receptors CB1 located in the nervous system, and CB2 in the brain and some parts of the immune system, notably in the spleen.
Localization (located) of CB2 in nervous system associated with cannabinoid receptor and agonist
15) Confidence 0.11 Published 2009 Journal Journal of Toxicology Section Body Doc Link PMC2809366 Disease Relevance 0.10 Pain Relevance 0.39
CB1 receptors are widely distributed in the central nervous system and peripheral sensory neurons, whereas CB2 receptors have been found in peripheral tissues including tissues of the immune system and keratinocytes with limited expression in sensory and central nervous system cells.58
Localization (receptors) of CB2 in keratinocytes associated with central nervous system
16) Confidence 0.05 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004649 Disease Relevance 0.61 Pain Relevance 1.41

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