INT168409

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Context Info
Confidence 0.64
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 47
Total Number 49
Disease Relevance 45.84
Pain Relevance 10.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl5) extracellular region (Ccl5) intracellular (Ccl5)
cell-cell signaling (Ccl5) cytoplasm (Ccl5)
Anatomy Link Frequency
brain 7
cerebellum 3
lung 3
T cells 3
plasma 2
Ccl5 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 1410 100.00 Very High Very High Very High
Inflammation 863 100.00 Very High Very High Very High
cytokine 540 100.00 Very High Very High Very High
Multiple sclerosis 494 99.40 Very High Very High Very High
antagonist 73 99.16 Very High Very High Very High
Central nervous system 452 96.80 Very High Very High Very High
endometriosis 92 96.20 Very High Very High Very High
Inflammatory response 100 95.04 Very High Very High Very High
Demyelination 97 87.84 High High
corticosteroid 16 83.36 Quite High
Disease Link Frequency Relevance Heat
Infection 1141 100.00 Very High Very High Very High
INFLAMMATION 941 100.00 Very High Very High Very High
Injury 36 100.00 Very High Very High Very High
Endometriosis 131 99.84 Very High Very High Very High
Reprotox - General 1 41 99.84 Very High Very High Very High
Multiple Sclerosis 718 99.78 Very High Very High Very High
Malaria 768 99.40 Very High Very High Very High
Demyelinating Disease 625 99.40 Very High Very High Very High
Chlamydia Infection 500 99.36 Very High Very High Very High
Aging 65 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that increases in CCL5, CCR5, and IFN-?
Positive_regulation (increases) of CCL5
1) Confidence 0.64 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 1.12 Pain Relevance 0.14
These findings coincide with marked increases in CCL5 and IFN-?
Positive_regulation (increases) of CCL5
2) Confidence 0.64 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.56 Pain Relevance 0.12
Sarfo and colleagues indicated that RANTES and its receptors CCR3 and CCR5 were upregulated in the cerebellum and cerebrum of post-mortem human CM tissue samples [8].
Positive_regulation (upregulated) of RANTES in cerebrum associated with cerebral malaria
3) Confidence 0.59 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.63 Pain Relevance 0.20
It has been observed that C-C chemokines, such as MIP-1-alpha and RANTES, are significantly upregulated in brains of Trypanosoma brucei brucei infected rats [34].
Positive_regulation (upregulated) of RANTES in brains associated with chemokine
4) Confidence 0.59 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.39 Pain Relevance 0.23
Interestingly, chemokines such as Cxcl9, Cxcl10, Cxcl11, Cxcl13, Ccl3, Ccl5 and Ccl12, Fc-receptor such as Fcer1g, and Mif genes were upregulated.
Positive_regulation (upregulated) of Ccl5 associated with chemokine
5) Confidence 0.54 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.89 Pain Relevance 0.62
Most importantly, chemokine genes e.g., Cxcl9, Cxcl10, Cxcl11, Cxcl13, Ccl3, Ccl5 and Ccl12 that exert a chemotactic signal for the immune cell migration to the site of the injury were upregulated at 72 and 96 hr post infection.
Positive_regulation (upregulated) of Ccl5 in immune cell associated with chemokine, injury and infection
6) Confidence 0.54 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.51 Pain Relevance 0.26
The ELISA data from this study indicate significant upregulation (p = 0.049 for day 4 and p < 0.026 for day six and day eight post-infection) of RANTES in P. yoelii 17XL-infected mouse plasma than in controls (Figure 3B).
Positive_regulation (upregulation) of RANTES in plasma associated with infection
7) Confidence 0.52 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.01 Pain Relevance 0.09
In contrast, Bartosik-Psujek and Stelmasiak [61] observed an increase in both CCL2 and CCL5 in the CSF of patients with IND, and suggested that the drop of CCL2 during relapses is characteristic only of MS.
Positive_regulation (increase) of CCL5 associated with multiple sclerosis, neurological disease and recurrence
8) Confidence 0.51 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 2.10 Pain Relevance 0.46
CCL3 and CCL4 are also CCR5 ligands, but these chemokines were not remarkably elevated compared to CCL5, which was the most abundant CCR5 ligand expressed during the early stages (i.e., < 7 days) of chlamydial infection.
Neg (not) Positive_regulation (elevated) of CCL5 associated with chemokine and chlamydia infection
9) Confidence 0.47 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.61 Pain Relevance 0.16
These results suggest that CCL5 is required in part for optimal Chlamydia-specific IgA Ab responses during C. muridarum infection.
Positive_regulation (required) of CCL5 associated with chlamydia infection and infection
10) Confidence 0.47 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.80 Pain Relevance 0.24
These results suggest that CCL5 is required for optimal generation of Chlamydia-specific CD4+ T cells that proliferate after Ag recognition.


Positive_regulation (required) of CCL5 in T cells associated with chlamydia infection
11) Confidence 0.47 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.70 Pain Relevance 0.06
CCL5 is known to be upregulated in prostate cancer [31].
Positive_regulation (upregulated) of CCL5 associated with reprotox - general 1
12) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944821 Disease Relevance 0.74 Pain Relevance 0.12
Also, chemokine profiles in the acute phase were different, with high levels of RANTES found in mice infected either both strains, but with higher levels of cardiac MIG, MCP-1, and MIP-1?
Positive_regulation (levels) of RANTES associated with chemokine and sprains and strains
13) Confidence 0.44 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2852613 Disease Relevance 0.75 Pain Relevance 0.22
The present study revealed that CCR5 and CCL5 mRNAs are elevated in the spleen, iliac lymph nodes (ILNs), and genital mucosa following Chlamydia muriduram challenge.
Positive_regulation (elevated) of CCL5 in lymph nodes associated with chlamydia infection
14) Confidence 0.43 Published 2008 Journal BMC Microbiol Section Abstract Doc Link PMC2543025 Disease Relevance 0.59 Pain Relevance 0.04
A significant increase in CCR5, CCL5, and IFN?
Positive_regulation (increase) of CCL5
15) Confidence 0.43 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 1.42 Pain Relevance 0.12
Furthermore, activated T-lymphocytes, platelets and endothelial cells release large amount of RANTES 3–5 days after activation, giving this chemokine a unique role in the generation, maintenance and prolongation of immune and inflammatory response [23].
Positive_regulation (activated) of RANTES 3 in T-lymphocytes associated with chemokine and inflammatory response
16) Confidence 0.43 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.65 Pain Relevance 0.21
EAE induction enhanced cerebral production of the chemokines CCL2 and CCL5 in WT mice (Figure 4A, B).
Positive_regulation (enhanced) of CCL5 associated with chemokine and multiple sclerosis
17) Confidence 0.40 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2596102 Disease Relevance 1.06 Pain Relevance 0.27
Genes encoding induced RANTES, CCR1, CCR3 and CCR5 were selectively confirmed by semi-quantitative RT-PCR.
Positive_regulation (induced) of RANTES
18) Confidence 0.40 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.14 Pain Relevance 0.03
The upregulation of RANTES, CCR1, CCR3, and CCR5 mRNA, and RANTES protein mediate inflammation and cellular degradation in the cerebellum during P. yoelii 17XL malaria.



Positive_regulation (upregulation) of RANTES in cerebellum associated with malaria and inflammation
19) Confidence 0.40 Published 2005 Journal Malar J Section Abstract Doc Link PMC1343570 Disease Relevance 0.44 Pain Relevance 0.08
RANTES protein in the brain of infected mice was upregulated (p < 0.034) compared with controls.
Positive_regulation (upregulated) of RANTES in brain
20) Confidence 0.40 Published 2005 Journal Malar J Section Abstract Doc Link PMC1343570 Disease Relevance 0.47 Pain Relevance 0.07

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