INT168410

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Context Info
Confidence 0.75
First Reported 2003
Last Reported 2011
Negated 3
Speculated 4
Reported most in Body
Documents 81
Total Number 86
Disease Relevance 84.03
Pain Relevance 37.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcr3) plasma membrane (Cxcr3) signal transducer activity (Cxcr3)
Anatomy Link Frequency
T cells 15
leukocytes 5
mast cells 4
neutrophils 3
macrophages 2
Cxcr3 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 2072 100.00 Very High Very High Very High
cytokine 805 100.00 Very High Very High Very High
rheumatoid arthritis 4708 99.96 Very High Very High Very High
Osteoarthritis 2300 99.88 Very High Very High Very High
Inflammation 1834 99.82 Very High Very High Very High
interstitial cystitis 492 99.20 Very High Very High Very High
Multiple sclerosis 255 97.64 Very High Very High Very High
Lasting pain 12 96.76 Very High Very High Very High
Arthritis 325 95.52 Very High Very High Very High
Central nervous system 205 92.64 High High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 4712 99.96 Very High Very High Very High
Osteoarthritis 2300 99.88 Very High Very High Very High
Cancer 278 99.86 Very High Very High Very High
INFLAMMATION 1852 99.82 Very High Very High Very High
Colitis 783 99.76 Very High Very High Very High
Disease 1421 99.70 Very High Very High Very High
Cystitis 840 99.40 Very High Very High Very High
Interstitial Cystitis 492 99.20 Very High Very High Very High
Disease Progression 21 98.68 Very High Very High Very High
Mycobacterial Infection 312 98.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To this end, CXCR3 expression and CXCL10-signaling by sensory neurons correlate with the maintenance phase of persistent pain [19].
Gene_expression (expression) of CXCR3 in sensory neurons associated with pain and lasting pain
1) Confidence 0.75 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.65 Pain Relevance 0.55
Urinary bladder histology as well as mucosal (iliac lymph node and urinary bladder) and peripheral (spleen) leukocyte expression of CXCR3, CXCL9, CXCL10, and CXCL11 mRNA transcripts as well as CD4+ T cell, mast cell, and NK/NKT cell numbers were compared among naïve and CYP-treated mice given control or anti-CXCL10 Abs.
Gene_expression (expression) of CXCR3 in T cell
2) Confidence 0.75 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.23 Pain Relevance 0.37
NK and NKT cells express CXCR3 and have been shown to be involved in the differentiation of naïve CD4+ T cells to Th1 cells [68].
Gene_expression (express) of CXCR3 in T cells
3) Confidence 0.75 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.00 Pain Relevance 0.51
Using immunohistochemistry, CXCR3 protein was found to be preferentially expressed on mast cells within synovial tissue from RA patients.
Gene_expression (expressed) of CXCR3 protein in mast cells associated with rheumatoid arthritis
4) Confidence 0.74 Published 2003 Journal Arthritis Res Ther Section Abstract Doc Link PMC193722 Disease Relevance 1.52 Pain Relevance 0.68
To our knowledge, this is the first report to demonstrate expression of CXCR3 in MCs within synovial tissue of RA patients.
Gene_expression (expression) of CXCR3 associated with rheumatoid arthritis
5) Confidence 0.74 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.30 Pain Relevance 0.69
High CXCR3 expression in synovial mast cells associated with CXCL9 and CXCL10 expression in inflammatory synovial tissues of patients with rheumatoid arthritis

To improve our knowledge on the pathophysiology of rheumatoid arthritis (RA), we investigated gene expression patterns in synovial tissue from RA and osteoarthritis (OA) patients.

Spec (investigated) Gene_expression (expression) of CXCR3 in mast cells associated with inflammation, rheumatoid arthritis and osteoarthritis
6) Confidence 0.74 Published 2003 Journal Arthritis Res Ther Section Title Doc Link PMC193722 Disease Relevance 1.17 Pain Relevance 0.56
High CXCR3 expression was originally shown to be restricted to activated T lymphocytes [5,22,23] and could be observed in resting T lymphocytes, B lymphocytes, monocytes or granulocytes [20,24].
Gene_expression (expression) of CXCR3 in T lymphocytes
7) Confidence 0.74 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0.40 Pain Relevance 0.58
The present study suggests that Th1-associated CXCR3 expression in synovial tissue is associated with distinct biologic functions of MCs in RA.
Gene_expression (expression) of CXCR3 associated with rheumatoid arthritis
8) Confidence 0.74 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.02 Pain Relevance 0.55
MC-associated CXCR3 expression may indicate that additional mechanism exist that result in an amplified proinflammatory stimulus, by secretion of proteinases, chemotactic factors, and vasoactive material [46].
Gene_expression (expression) of CXCR3
9) Confidence 0.74 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0.63 Pain Relevance 0.32
The chemokine receptor CXCR3 was previously found to be strongly expressed on activated T lymphocytes, exhibiting lower or no detectable expression in resting T cells, B cells, monocytes, or granulocytes [6].
Gene_expression (expressed) of CXCR3 in B cells associated with chemokine
10) Confidence 0.74 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.10 Pain Relevance 0.57
Evaluation of CXCR3 protein expression
Gene_expression (expression) of CXCR3 protein
11) Confidence 0.74 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.37 Pain Relevance 0.63
Additional expression of CXCR3 protein on synovial fibroblasts in both RA and OA points possibly to an increased level of activation among these cells.
Gene_expression (expression) of CXCR3 protein in fibroblasts associated with rheumatoid arthritis and osteoarthritis
12) Confidence 0.74 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.24 Pain Relevance 0.67
These findings suggest that substantial expression of CXCR3 protein on mast cells within synovial tissue from RA patients plays a significant role in the pathophysiology of RA, accompanied by elevated levels of the chemokines CXCL9 and CXCL10.
Gene_expression (expression) of CXCR3 protein in mast cells associated with chemokine and rheumatoid arthritis
13) Confidence 0.74 Published 2003 Journal Arthritis Res Ther Section Abstract Doc Link PMC193722 Disease Relevance 1.48 Pain Relevance 0.66
To confirm the increase in CXCR3 expression at the protein level, Western blot experiments in selected extracts from synovial tissue of RA and OA patients were conducted (Fig. 3a).
Gene_expression (expression) of CXCR3 associated with rheumatoid arthritis and osteoarthritis
14) Confidence 0.74 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.43 Pain Relevance 0.66
Thus, CXCR3 expression does not appear to be restricted to activated T lymphocytes, and chemokines may attract more than just T lymphocytes.
Gene_expression (expression) of CXCR3 in T lymphocytes associated with chemokine
15) Confidence 0.74 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0.51 Pain Relevance 0.46
Thus, in agreement with differential mRNA expression, CXCR1 and CXCR3 proteins were expressed in synovial tissue from patients with RA at higher levels than in tissues from patients with OA.


Gene_expression (expressed) of CXCR3 associated with rheumatoid arthritis and osteoarthritis
16) Confidence 0.74 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.51 Pain Relevance 0.67
It is likely that MC precursors can also be recruited to sites of inflammation through their additional CXCR3 surface expression and support the characteristic features of RA.
Gene_expression (expression) of CXCR3 associated with inflammation and rheumatoid arthritis
17) Confidence 0.74 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.15 Pain Relevance 0.50
In RA, CXCR3 expression was also found to be restricted to lymphocytic cells in perivascular inflammatory infiltrates within active lesions of synovial tissue [5,20,25].
Gene_expression (expression) of CXCR3 associated with inflammation and rheumatoid arthritis
18) Confidence 0.74 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0.94 Pain Relevance 0.47
The most exciting observation was the strong CXCR3 protein expression on tissue MCs in RA synovial tissue.
Gene_expression (expression) of CXCR3 protein associated with rheumatoid arthritis
19) Confidence 0.74 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.47 Pain Relevance 0.79
Although CXCR3 expression was previously demonstrated in synovial tissue of RA patients, high CXCR3 mRNA levels in synovial MCs has not yet been described [5,17].
Gene_expression (expression) of CXCR3 associated with rheumatoid arthritis
20) Confidence 0.74 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.95 Pain Relevance 1.08

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