INT168415

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Context Info
Confidence 0.26
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.94
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

MIR146A (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 11 97.80 Very High Very High Very High
rheumatoid arthritis 168 95.60 Very High Very High Very High
Inflammation 39 90.64 High High
tolerance 3 82.36 Quite High
psoriasis 7 80.64 Quite High
spinal inflammation 3 76.40 Quite High
cytokine 36 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 27 99.60 Very High Very High Very High
Arthritis 13 97.80 Very High Very High Very High
Immune System Diseases 1 96.20 Very High Very High Very High
Rheumatoid Arthritis 168 95.60 Very High Very High Very High
INFLAMMATION 39 90.64 High High
Death 18 86.08 High High
Psoriasis 7 80.64 Quite High
Low Back Pain 3 76.40 Quite High
Apoptosis 72 75.72 Quite High
Seronegative Spondarthritis 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study explores the association of miRNA-146a variant rs2910164 and of two IRAK1 (target of miR-146a) polymorphisms rs3027898 and rs1059703 with psoriasic arthritis (PsA).
Regulation (target) of miR-146a associated with arthritis
1) Confidence 0.26 Published 2010 Journal Scand. J. Immunol. Section Abstract Doc Link 20500689 Disease Relevance 0.90 Pain Relevance 0.51
It seems that miR-146a regulate cell function through targeting multiple targets as several targets of miR-146a were identified.
Regulation (targets) of miR-146a
2) Confidence 0.11 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.90 Pain Relevance 0.35
Interestingly, the expression of two targets of miR-146, TRAF6 and IL-1 receptor-associated kinase 1, remains unchanged although miR-146 is upregulated in PBMC from RA patients [22].
Regulation (targets) of miR-146 associated with rheumatoid arthritis
3) Confidence 0.11 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.79 Pain Relevance 0.12
As many genes such as IRAK1, IRAK2, TRAF6, FADD, IRF-5, STAT-1 and PTC1 have been found to be targets of miR-146a in human disease [20,31,34,46], the targets and functions of miR-146a may be different in specific cells.
Regulation (targets) of miR-146a associated with disease
4) Confidence 0.11 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.36 Pain Relevance 0.03

General Comments

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