INT168418

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Context Info
Confidence 0.55
First Reported 2005
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 32
Total Number 35
Disease Relevance 20.20
Pain Relevance 4.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 1
feces 1
face 1
heart 1
multipotent stem cells 1
RCT (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 211 99.68 Very High Very High Very High
Acupuncture 242 99.44 Very High Very High Very High
Pain 137 99.44 Very High Very High Very High
Inflammation 145 99.16 Very High Very High Very High
Analgesic 43 96.24 Very High Very High Very High
complementary and alternative medicine 11 88.08 High High
Bile 67 85.20 High High
imagery 139 84.44 Quite High
alcohol 103 83.76 Quite High
analgesia 5 83.60 Quite High
Disease Link Frequency Relevance Heat
Rotator Cuff Tears 142 100.00 Very High Very High Very High
Common Cold 88 100.00 Very High Very High Very High
Carcinoid 22 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 3536 99.92 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 59 99.88 Very High Very High Very High
Vasculitis 9 99.52 Very High Very High Very High
Pain 143 99.44 Very High Very High Very High
Pneumonia 52 98.84 Very High Very High Very High
Coronary Heart Disease 513 98.66 Very High Very High Very High
Bacterial Meningitis 12 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This assumption is supported by the findings of Itoi et al. [32] that a pain block produced significant increase in strength of abduction in full RCT.
Positive_regulation (increase) of RCT associated with pain and rotator cuff tears
1) Confidence 0.55 Published 2010 Journal J Orthop Traumatol Section Body Doc Link PMC2837810 Disease Relevance 1.22 Pain Relevance 0.54
The increased fecal cholesterol excretion observed in running mice is likely explained by higher endogenous cholesterol synthesis, however, it does not reflect increased RCT in the face of unchanged expression of key transporters for biliary sterol secretion.



Neg (not) Positive_regulation (increased) of RCT in face
2) Confidence 0.54 Published 2010 Journal Nutr Metab (Lond) Section Abstract Doc Link PMC2903598 Disease Relevance 0 Pain Relevance 0.10
In the case a RCT will be activated in the context of the study, drugs compared in the RCT part of the study will be furnished by the Sponsor(s).
Positive_regulation (activated) of RCT
3) Confidence 0.51 Published 2006 Journal Health Qual Life Outcomes Section Body Doc Link PMC1402259 Disease Relevance 0.32 Pain Relevance 0.33
Hence, results of the RCT may not be applicable to such workplaces.
Positive_regulation (results) of RCT
4) Confidence 0.36 Published 2010 Journal BMC Med Res Methodol Section Body Doc Link PMC2895606 Disease Relevance 0 Pain Relevance 0
The plasma lathosterol/cholesterol ratio as a measure of endogenous cholesterol synthesis was significantly higher in the running mice (Figure 4) indicating that the increased amount of fecal sterols secreted in this group is rather originating from increased cholesterol synthesis than reflecting increased RCT.


Positive_regulation (increased) of RCT in plasma
5) Confidence 0.36 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2903598 Disease Relevance 0.14 Pain Relevance 0.11
METHODS/DESIGN: A prospective, multi-center RCT will be conducted in nine centers in the Netherlands and Belgium.
Positive_regulation (conducted) of RCT
6) Confidence 0.26 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link 20500849 Disease Relevance 0.19 Pain Relevance 0
also augments the cholesterol efflux, accelerates RCT and raises the HDL level.
Positive_regulation (accelerates) of RCT associated with disorder of lipid metabolism
7) Confidence 0.15 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.23 Pain Relevance 0.23
The mechanisms, by which exercise and reduced weight increase HDL-C likely involves enchanced lipoprotein lipase (LL) activity, increased RCT, and increased levels of pre-?
Positive_regulation (increased) of RCT associated with disorder of lipid metabolism
8) Confidence 0.15 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.00 Pain Relevance 0.04
The mechanisms, by which exercise and reduced weight increase HDL-C likely involves enchanced lipoprotein lipase (LL) activity, increased RCT, and increased levels of pre-?
Positive_regulation (increased) of RCT associated with disorder of lipid metabolism
9) Confidence 0.15 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.00 Pain Relevance 0.04
activation, fibrates increase circulating levels of HDL-C, enhance RCT and reduce vascular inflammation and thrombogenicity (Barbier et al 2002; Gervois et al 2007).
Positive_regulation (enhance) of RCT associated with inflammation, vasculitis and disorder of lipid metabolism
10) Confidence 0.15 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.68 Pain Relevance 0.23
One such synthetic agent, GW3965, was found to increase the rate of RCT in vivo without inducing hepatic steatosis.
Positive_regulation (increase) of RCT
11) Confidence 0.11 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 0.66 Pain Relevance 0.25
Therefore, inhibition of CETP activity can potentially provide a therapeutic benefit for patients with CHD by allowing HDL particles to accumulate and be more available for augmenting the RCT process that scavenges cholesterol from the tissues.
Positive_regulation (augmenting) of RCT associated with coronary heart disease and disorder of lipid metabolism
12) Confidence 0.11 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 0.96 Pain Relevance 0
AIM homodimers and heterodimers may enhance cholesterol efflux thereby augmenting RCT (Chiesa et al 2002).
Positive_regulation (augmenting) of RCT
13) Confidence 0.11 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.74 Pain Relevance 0
and by enhancing expression of Apo AI and AII, LL, and ABCA1, which collectively enhance RCT (Tilly-Kiesi et al 1992).
Positive_regulation (enhance) of RCT
14) Confidence 0.11 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.08 Pain Relevance 0.03
HDL, and enhance RCT in humans (Westman et al 1995; Eriksson et al 1999).
Positive_regulation (enhance) of RCT associated with disorder of lipid metabolism
15) Confidence 0.11 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.84 Pain Relevance 0
CETP activity may promote RCT by stimulating LCAT activity and regenerating pre-?
Spec (may) Positive_regulation (promote) of RCT
16) Confidence 0.11 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.02 Pain Relevance 0.06
Exogenous administration of Apo AI directly enhances RCT via the ABCA1 pathway (Zhang et al 2003; Navab et al 2004; Arakawa et al 2004).
Positive_regulation (enhances) of RCT
17) Confidence 0.11 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.79 Pain Relevance 0.08
Recently administration of the LXR agonist GW3965 to mice increased the rate of RCT from macrophages to feces in vivo (Naik et al 2006).
Positive_regulation (increased) of RCT in feces associated with agonist
18) Confidence 0.11 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.76 Pain Relevance 0.33
A large international RCT is currently being conducted to test the hypothesis that perioperative administration of beta-adrenergic blockers in patients with risk factors for ischaemic heart disease reduces mortality (the 'POISE' study).


Positive_regulation (conducted) of RCT in heart associated with coronary heart disease
19) Confidence 0.08 Published 2005 Journal Crit Care Section Body Doc Link PMC1065089 Disease Relevance 0.48 Pain Relevance 0.23
A prospective, multi-center RCT will be conducted in nine centers in the Netherlands and Belgium.
Positive_regulation (conducted) of RCT
20) Confidence 0.08 Published 2010 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2887776 Disease Relevance 0.86 Pain Relevance 0.40

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