INT168432

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.89
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Gpx1) mitochondrion (Gpx1) oxidoreductase activity (Gpx1)
nucleus (Gpx1) lipid metabolic process (Gpx1) cytoplasm (Gpx1)
Anatomy Link Frequency
liver 2
paw 2
Gpx1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 11 99.04 Very High Very High Very High
Analgesic 5 95.96 Very High Very High Very High
aspirin 48 90.88 High High
ischemia 1 70.88 Quite High
ketamine 3 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Inflammatory stimuli 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
analgesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 6 100.00 Very High Very High Very High
Diabetes Mellitus 96 99.32 Very High Very High Very High
INFLAMMATION 13 99.04 Very High Very High Very High
Lung Injury 4 96.24 Very High Very High Very High
Heart Rate Under Development 52 91.24 High High
Cataract 45 87.76 High High
Cv Unclassified Under Development 1 70.88 Quite High
Edema 6 60.20 Quite High
Weight Loss 2 47.64 Quite Low
Stress 25 41.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The anti-inflammatory mechanism of FL and FM might be related to the decrease in the level of MDA in the edema paw via increasing the activities of GPx and GRx in the liver and decreasing the NO level in the edema paw.
Negative_regulation (decrease) of Positive_regulation (increasing) of GPx in paw associated with pressure and volume under development and inflammation
1) Confidence 0.40 Published 2010 Journal Am. J. Chin. Med. Section Abstract Doc Link 20503477 Disease Relevance 0.92 Pain Relevance 0.43
The mechanisms of the protective effects of taurine may be related to the decrease of MDA level and the increase of SOD and GPx activity.
Negative_regulation (decrease) of Positive_regulation (increase) of GPx
2) Confidence 0.09 Published 2008 Journal J Cardiothorac Surg Section Body Doc Link PMC2583976 Disease Relevance 0.78 Pain Relevance 0.07
The combination treatment not only mitigated the decrease in water-solution proteins but also mitigated the decrease in thiol levels, and the increase in activity of GPx, some more than other treatments.
Negative_regulation (decrease) of Positive_regulation (increase) of GPx
3) Confidence 0.07 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2773744 Disease Relevance 0.53 Pain Relevance 0.25
The decreased activities of SOD, CAT and GPx in liver during diabetes mellitus may be due to the production of reactive oxygen free radicals that can themselves reduce the activity of these enzymes.[3338] These enzymes could destroy the peroxides and play a significant role in providing antioxidant defenses to an organism.
Negative_regulation (decreased) of Positive_regulation (activities) of GPx in liver associated with diabetes mellitus
4) Confidence 0.06 Published 2010 Journal Pharmacognosy Magazine Section Body Doc Link PMC2950386 Disease Relevance 0.66 Pain Relevance 0

General Comments

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