INT168444

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Context Info
Confidence 0.43
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.93
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (C2) extracellular region (C2)
Anatomy Link Frequency
central nervous system 2
C2 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 15 100.00 Very High Very High Very High
Glutamate 14 100.00 Very High Very High Very High
Antinociceptive 30 99.98 Very High Very High Very High
Glutamate receptor 2 97.96 Very High Very High Very High
transcutaneous nerve stimulation 6 96.56 Very High Very High Very High
Central nervous system 1 95.68 Very High Very High Very High
nMDA receptor antagonist 1 54.88 Quite High
nMDA receptor 1 48.56 Quite Low
opioid receptor 4 45.52 Quite Low
Pain 8 41.40 Quite Low
Disease Link Frequency Relevance Heat
Tinnitus 9 99.36 Very High Very High Very High
Nociception 11 82.64 Quite High
Stress 3 72.80 Quite High
Pain 7 41.40 Quite Low
INFLAMMATION 7 5.00 Very Low Very Low Very Low
Inflammatory Pain 1 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, these previous findings and the present results suggested that the antinociceptive action of compounds C1 and C2 in the acetic acid, capsaicin, and glutamate tests could be the result of both the inhibition of NOS and the blockade of glutamate receptors.
Positive_regulation (result) of Positive_regulation (action) of C2 associated with glutamate, qutenza, glutamate receptor and antinociceptive
1) Confidence 0.43 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2817697 Disease Relevance 0.28 Pain Relevance 0.39
As electrical stimulation of C2 increases activation of the DCN through the somatosensory pathway and enlarges the inhibitory role of the DCN on the central nervous system, C2 TENS can be considered for tinnitus modulation.
Positive_regulation (increases) of Positive_regulation (stimulation) of C2 in central nervous system associated with tinnitus, transcutaneous nerve stimulation and central nervous system
2) Confidence 0.39 Published 2010 Journal Exp Brain Res Section Abstract Doc Link 20505927 Disease Relevance 0.65 Pain Relevance 0.46

General Comments

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