INT168446

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Context Info
Confidence 0.64
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 25
Total Number 25
Disease Relevance 15.17
Pain Relevance 5.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prep) peptidase activity (Prep) nucleus (Prep)
cytoplasm (Prep)
Anatomy Link Frequency
posterior 3
macrophages 2
brain 2
tube 1
leukocytes 1
Prep (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 146 98.72 Very High Very High Very High
methotrexate 400 98.68 Very High Very High Very High
Dismenorea 24 98.48 Very High Very High Very High
Inflammation 208 98.36 Very High Very High Very High
cINOD 2 97.56 Very High Very High Very High
Hyperalgesia 31 96.44 Very High Very High Very High
substance P 90 95.44 Very High Very High Very High
rheumatoid arthritis 11 94.88 High High
bradykinin 60 92.64 High High
medulla 2 92.12 High High
Disease Link Frequency Relevance Heat
Stress 246 100.00 Very High Very High Very High
Pelvic Organ Prolapse 86 100.00 Very High Very High Very High
Pharyngitis 38 100.00 Very High Very High Very High
Pancreatitis 14 100.00 Very High Very High Very High
Obesity 341 99.92 Very High Very High Very High
Cough 8 99.92 Very High Very High Very High
Hoarseness 9 99.48 Very High Very High Very High
Aging 249 99.04 Very High Very High Very High
Pain 130 98.72 Very High Very High Very High
Syndrome 21 98.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Failure was assigned to postoperative POP-Q stage II or greater, i.e., its quantitation value was ?
Gene_expression (postoperative) of POP associated with pelvic organ prolapse
1) Confidence 0.64 Published 2010 Journal Korean Journal of Urology Section Body Doc Link PMC2855447 Disease Relevance 1.27 Pain Relevance 0
since POP activity in murine M?
Gene_expression (activity) of POP
2) Confidence 0.63 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2266974 Disease Relevance 0.24 Pain Relevance 0.57
1) treatments on dipeptidyl peptidase IV (DPPIV) and prolyl oligopeptidase (POP) activities and on algesic response in two distinct status of murine macrophages (M?
Gene_expression (activities) of POP in macrophages
3) Confidence 0.63 Published 2008 Journal Clinical and Developmental Immunology Section Abstract Doc Link PMC2266974 Disease Relevance 0 Pain Relevance 0.22
change the reaction to the same algesic stimulus, it is likely that besides POP
Gene_expression (besides) of POP
4) Confidence 0.63 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2266974 Disease Relevance 0.53 Pain Relevance 0.87
DPPIV activity below a critical level, as observed here for POP activity of
Gene_expression (activity) of POP
5) Confidence 0.63 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2266974 Disease Relevance 0.34 Pain Relevance 0.48
1) treatments on dipeptidyl peptidase IV (DPPIV) and prolyl oligopeptidase (POP) activities and on algesic response in two distinct status of murine macrophages (M?
Gene_expression (activities) of prolyl oligopeptidase in macrophages
6) Confidence 0.63 Published 2008 Journal Clinical and Developmental Immunology Section Abstract Doc Link PMC2266974 Disease Relevance 0 Pain Relevance 0.22
The aim of this guideline commissioned by the European Society of Gastrointestinal Endoscopy (ESGE) is to provide practical, graded, recommendations for the prevention of PEP.
Neg (prevention) Gene_expression (prevention) of PEP associated with pancreatitis
7) Confidence 0.57 Published 2010 Journal Endoscopy Section Abstract Doc Link 20506068 Disease Relevance 0.67 Pain Relevance 0.13
Prevention of PEP includes administration of nonsteroidal inflammatory drugs (NSAIDs), use of specific cannulation techniques, and placement of temporary pancreatic stents.
Gene_expression (Prevention) of PEP associated with inflammation, pancreatitis and cinod
8) Confidence 0.57 Published 2010 Journal Endoscopy Section Abstract Doc Link 20506068 Disease Relevance 0.65 Pain Relevance 0.15
disturbances were made when increased POP levels in synovial membrane
Gene_expression (levels) of POP
9) Confidence 0.55 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2266974 Disease Relevance 0.99 Pain Relevance 0.38
Other links between POP and immunological
Gene_expression (immunological) of POP
10) Confidence 0.55 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2266974 Disease Relevance 0.97 Pain Relevance 0.37
CsA had opposite effects on POP activity of TGE M?
Gene_expression (activity) of POP
11) Confidence 0.55 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2266974 Disease Relevance 0.57 Pain Relevance 0.60
and membrane-bound (1.8-fold) DPPIV and soluble POP (1.8-fold) in the TGE M?
Gene_expression (soluble) of POP
12) Confidence 0.55 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2266974 Disease Relevance 0 Pain Relevance 0.19
DPPIV and POP activity levels with the in vivo excitability to thermal pain stimulus could highlight the in vivo role of these peptidases through their actions on those inflammatory and nociceptive mediators after their generation and release by M?
Gene_expression (levels) of POP associated with nociception, pain and inflammation
13) Confidence 0.55 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2266974 Disease Relevance 0.95 Pain Relevance 0.65
Therefore, because POP is exclusively expressed by neurons and display region-specific distribution in the mouse brain, POP-activated prodrugs may be especially useful to target neurons in select regions (cortex, cerebellum, striatum and mid-brain) of the brain.


Gene_expression (expressed) of POP in brain
14) Confidence 0.18 Published 2008 Journal The Open Medicinal Chemistry Journal Section Body Doc Link PMC2709471 Disease Relevance 0 Pain Relevance 0.24
Anatomic success was defined as ICS POP stage 0 or I of the posterior compartment.
Gene_expression (stage 0) of POP in posterior associated with pelvic organ prolapse
15) Confidence 0.17 Published 2010 Journal Int Urogynecol J Section Body Doc Link PMC2858280 Disease Relevance 0.52 Pain Relevance 0.10
To a somewhat lesser extent, this could be demonstrated for the posterior compartment as well; in a group of patients with POP stage ?
Gene_expression (stage) of POP in posterior associated with pelvic organ prolapse
16) Confidence 0.17 Published 2010 Journal Int Urogynecol J Section Body Doc Link PMC2858280 Disease Relevance 0.42 Pain Relevance 0
Posterior POP stage???
Gene_expression (stage) of POP in Posterior associated with pelvic organ prolapse
17) Confidence 0.17 Published 2010 Journal Int Urogynecol J Section Body Doc Link PMC2858280 Disease Relevance 0.56 Pain Relevance 0.06
These data indicate that myostatin is upregulated following PE stress.


Gene_expression (stress) of PE associated with stress
18) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2856679 Disease Relevance 0.55 Pain Relevance 0
As shown in Figures 1A–D, PE stress did indeed activate Akt (and downstream GSK3- ?)
Gene_expression (stress) of PE associated with stress
19) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2856679 Disease Relevance 0.37 Pain Relevance 0
Therefore, it appears that myostatin upregulation following PE stress is Erk dependent.
Gene_expression (stress) of PE associated with stress
20) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2856679 Disease Relevance 1.11 Pain Relevance 0

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