INT168469

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Context Info
Confidence 0.28
First Reported 2002
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.46
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Lgals3) extracellular region (Lgals3) mRNA processing (Lgals3)
proteinaceous extracellular matrix (Lgals3) plasma membrane (Lgals3) nucleus (Lgals3)
Anatomy Link Frequency
retina 1
immune system 1
Podocytes 1
Lgals3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 4 93.44 High High
melanocortin 1 receptor 1 75.00 Quite High
anesthesia 5 31.84 Quite Low
Inflammation 11 5.00 Very Low Very Low Very Low
Spinal cord 6 5.00 Very Low Very Low Very Low
ketamine 5 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
gABA 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Recurrence 11 99.56 Very High Very High Very High
Conjunctiva Disease 18 98.52 Very High Very High Very High
Membranous Glomerulonephritis 6 97.52 Very High Very High Very High
Disease 4 95.36 Very High Very High Very High
Diabetes Mellitus 62 95.08 Very High Very High Very High
Rhinitis 4 94.56 High High
Proteinuria 5 90.48 High High
Conjunctival Diseases 1 89.80 High High
Disorder Of Lipid Metabolism 2 85.72 High High
Stress 4 78.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of particular interest for future studies are those proteins that are not normalized (Fgf2 and Crybb2) or only partially normalized (Cp, Cryba3, Lgals3, Stat3) by insulin treatment, as these persistent changes reflect the limitations of insulin to restore the retina to a nondiabetic state.
Neg (not) Localization (normalized) of Lgals3 in retina
1) Confidence 0.28 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.17 Pain Relevance 0
Regarding which substances were more responsible for insufficient development of the immune system and elevation of IgE, filtered-exhaust that included the gaseous phase and ultra fine particles measuring less than 0.05 ?
Localization (elevation) of IgE in immune system
2) Confidence 0.27 Published 2002 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC101391 Disease Relevance 0.45 Pain Relevance 0
Aims:
The purpose of this study was to determine whether concanavalin A (ConA) lectin bound to the pterygial surface can be used to detect recurrence or remnants of pterygium after surgical excision.


Localization (used) of lectin associated with conjunctiva disease and recurrence
3) Confidence 0.17 Published 2007 Journal Indian Journal of Ophthalmology Section Abstract Doc Link PMC2636009 Disease Relevance 0.73 Pain Relevance 0
Podocytes expressed most MC1R protein, which colocalized with synaptopodin but not with an endothelial-specific lectin.
Neg (not) Localization (colocalized) of lectin in Podocytes
4) Confidence 0.04 Published 2010 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 20507942 Disease Relevance 1.11 Pain Relevance 0.23
Due to the lectin binding properties and the subcellular localization of these three compounds, Nualart et al. [25] have selected a 15-aminoacid sequence from a region of SCO-spondin that was used to raise antibodies in rabbits.
Localization (localization) of lectin
5) Confidence 0.01 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2265671 Disease Relevance 0 Pain Relevance 0

General Comments

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