INT168502

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Context Info
Confidence 0.39
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 9.22
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (FUS) cell death (FUS) nucleolus (FUS)
RNA binding (FUS) nucleus (FUS) intracellular (FUS)
FUS (Homo sapiens)
Pain Link Frequency Relevance Heat
methotrexate 10 99.18 Very High Very High Very High
intrathecal 5 98.92 Very High Very High Very High
Onset of action 10 89.76 High High
corticosteroid 5 85.68 High High
palliative 1 83.16 Quite High
Pain 4 81.84 Quite High
imagery 3 67.48 Quite High
abdominal pain 6 66.84 Quite High
tolerance 1 46.12 Quite Low
adenocard 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Tumor Lysis Syndrome 410 100.00 Very High Very High Very High
Hyperuricemia 190 100.00 Very High Very High Very High
Acute Renal Failure 95 98.76 Very High Very High Very High
Chromosome Aberrations 2 98.04 Very High Very High Very High
Cancer 147 97.22 Very High Very High Very High
Disease 31 97.20 Very High Very High Very High
Sarcoma 6 92.40 High High
Malignant Neoplastic Disease 17 88.72 High High
Myxoid Liposarcoma 10 86.48 High High
Liposarcoma 9 84.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cytogenetically, the lesion has also been associated with the t (7,16) (q33;p11) translocation, with the characteristic resultant FUS and CREB3L2 fusion gene.
Positive_regulation (resultant) of FUS
1) Confidence 0.39 Published 2010 Journal J Foot Ankle Surg Section Abstract Doc Link 20510633 Disease Relevance 0.75 Pain Relevance 0.08
As myxoid and round cell tumours share the same cytogenetic abnormalities, namely the traslocation t(12;16)(q13;p11) leading to the fusion of the genes DDIT3 and FUS with generation of a hybrid protein FUS/DDIT3, some authors consider both lesions as a continuum of the same disease.
Positive_regulation (generation) of FUS associated with chromosome aberrations, cancer and disease
2) Confidence 0.33 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC2221973 Disease Relevance 1.32 Pain Relevance 0.18
Some chemotherapeutic agents such as cytosine arabinoside, etoposide, cisplatin, and intrathecal methotrexate have been more frequently implicated in causing TLS (Locatelli and Rossi 2005), although no one regimen or drug may be specifically indicated as carrying a higher likelihood of causing TLS.
Positive_regulation (causing) of TLS associated with tumor lysis syndrome, methotrexate and intrathecal
3) Confidence 0.33 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727789 Disease Relevance 1.89 Pain Relevance 0.14
At the present time, rasburicase provides an alternative for the prevention of TLS in patients at high risk and it is strongly suggested for the treatment of hyperuricemia and TLS.
Positive_regulation (suggested) of TLS associated with hyperuricemia and tumor lysis syndrome
4) Confidence 0.24 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727789 Disease Relevance 0.90 Pain Relevance 0.04
Only 5% of patients experienced severe metabolic problems after the initiation of therapy, and only 1.7% required dialysis as a result of TLS.
Positive_regulation (result) of TLS associated with tumor lysis syndrome
5) Confidence 0.22 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727789 Disease Relevance 0.42 Pain Relevance 0
Some chemotherapeutic agents such as cytosine arabinoside, etoposide, cisplatin, and intrathecal methotrexate have been more frequently implicated in causing TLS (Locatelli and Rossi 2005), although no one regimen or drug may be specifically indicated as carrying a higher likelihood of causing TLS.
Positive_regulation (causing) of TLS associated with tumor lysis syndrome, methotrexate and intrathecal
6) Confidence 0.22 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727789 Disease Relevance 1.76 Pain Relevance 0.14
In a recent study, sTLS in patients with malignancies is defined by presence of pretreatment hyperuricemic acute renal failure (ARF), ratio of urinary uric acid to creatinine (Cr) > 1.0, and significantly elevated lactate dehydrogenase (> 500 units/L); TLS was demonstrated to occur in 1.08% of 926 patients with ARF (Hsu et al 2004).
Positive_regulation (occur) of TLS associated with hyperuricemia, acute renal failure and tumor lysis syndrome
7) Confidence 0.22 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727789 Disease Relevance 2.18 Pain Relevance 0

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