INT168519

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Context Info
Confidence 0.61
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.75
Pain Relevance 1.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adora1) endoplasmic reticulum (Adora1) plasma membrane (Adora1)
signal transducer activity (Adora1)
Adora1 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 195 100.00 Very High Very High Very High
Acupuncture 8 99.06 Very High Very High Very High
nMDA receptor 6 96.84 Very High Very High Very High
Spinal cord 8 96.56 Very High Very High Very High
agonist 34 96.24 Very High Very High Very High
Analgesic 1 94.40 High High
Hippocampus 14 90.88 High High
Pain 4 89.08 High High
Pyramidal cell 7 88.60 High High
Glutamate 15 86.88 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 3 99.86 Very High Very High Very High
Nociception 4 99.82 Very High Very High Very High
Pain 2 89.08 High High
Heart Rate Under Development 19 77.96 Quite High
Drug Induced Neurotoxicity 2 47.44 Quite Low
Cv Unclassified Under Development 3 36.40 Quite Low
Convulsion 8 30.24 Quite Low
Depression 21 5.00 Very Low Very Low Very Low
Hypoxia 16 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that adenosine, a neuromodulator with anti-nociceptive properties, was released during acupuncture in mice and that its anti-nociceptive actions required adenosine A1 receptor expression.
Positive_regulation (required) of Gene_expression (expression) of A1 receptor associated with nociception, adenocard and acupuncture
1) Confidence 0.61 Published 2010 Journal Nat. Neurosci. Section Abstract Doc Link 20512135 Disease Relevance 0.44 Pain Relevance 0.91
Interaction between A1Rs and GABAA receptors
Positive_regulation (between) of Gene_expression (receptors) of A1R
2) Confidence 0.49 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0 Pain Relevance 0.62
In fact, in transgenic mice, overexpressing the A1AR, it was shown that the ?
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of A1AR associated with targeted disruption
3) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2727950 Disease Relevance 0.30 Pain Relevance 0.21
Effects of A1R manipulation on island rhythmogenesis during GABAA receptor antagonism
Positive_regulation (during) of Gene_expression (manipulation) of A1R
4) Confidence 0.38 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567986 Disease Relevance 0 Pain Relevance 0

General Comments

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