INT16854

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Context Info
Confidence 0.26
First Reported 1991
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 3.10
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Uts2r) plasma membrane (Uts2r) signal transducer activity (Uts2r)
Anatomy Link Frequency
neurons 1
internal 1
fibroblasts 1
kidney 1
Uts2r (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 22 97.00 Very High Very High Very High
Dopamine 160 93.72 High High
Hippocampus 48 83.28 Quite High
Catechol-O-methyltransferase 81 82.56 Quite High
tetrodotoxin 7 81.12 Quite High
addiction 9 77.84 Quite High
conotoxin 1 67.60 Quite High
alcohol 1 53.44 Quite High
adenocard 3 48.16 Quite Low
cytokine 31 46.64 Quite Low
Disease Link Frequency Relevance Heat
Sprains And Strains 180 100.00 Very High Very High Very High
Myotonia 28 97.20 Very High Very High Very High
Arrhythmias 2 Under Development 4 96.48 Very High Very High Very High
Frailty 20 95.56 Very High Very High Very High
Hypersensitivity 21 94.60 High High
Targeted Disruption 102 94.56 High High
Disease 183 84.08 Quite High
Drug Dependence 4 77.84 Quite High
Toxicity 36 74.64 Quite High
Cytomegalovirus Infection 8 73.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
UTR expression.
Gene_expression (expression) of UTR
1) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.41 Pain Relevance 0
UTR expression between the B and D alleles in the kidney compared to a 4-fold difference in coding exons from the same tissue.
Gene_expression (expression) of UTR in kidney
2) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.22 Pain Relevance 0.04
-UTR segment of each mouse gene predicted as target genes of let-7a-5C (C at the 5th position of let-7a) or let-7a (the reference sequence of let-7a, G at the 5th position) was amplified by PCR from mouse cDNAs and inserted into the downstream of luciferase reporter gene in the pGL3 control vector.
Gene_expression (segment) of UTR
3) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993968 Disease Relevance 0 Pain Relevance 0
UTR) of the DAT gene where the Cre gene is preceded by an internal ribosomal entry site (IRES).
Gene_expression (preceded) of UTR in internal
4) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.24 Pain Relevance 0.46
UTR and strains without the insertion produce Comt with a long 3?
Gene_expression (produce) of UTR associated with sprains and strains
5) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.52 Pain Relevance 0.15
UTR, was synthesized by in vitro transcription with P32-?
Gene_expression (synthesized) of UTR
6) Confidence 0.17 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0.27 Pain Relevance 0.03
UTR, we co-transfected COS-7 fibroblasts with our miR-130a expression vector and our FOG-2 UTR reporter.
Gene_expression (transfected) of UTR in fibroblasts
7) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701631 Disease Relevance 0.07 Pain Relevance 0
In contrast, expression of a high number of copies of the DMPK 3’ UTR containing 5 CUG repeats leads to development of DM1-like phenotype (myotonia, cardiac conduction defects and muscular dystrophy) in the absence of nuclear CUG foci and in the absence of MBNL1 sequestration [34].
Gene_expression (expression) of UTR associated with myotonia, frailty and arrhythmias 2 under development
8) Confidence 0.13 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.78 Pain Relevance 0
What is the mechanism by which multiple copies of the normal 3’ UTR of DMPK cause DM1 phenotype?
Gene_expression (copies) of UTR
9) Confidence 0.11 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.51 Pain Relevance 0
-UTR of Foxp3 mRNA whereas miR-21 acts as a positive, though indirect, regulator of Foxp3 expression [117].
Gene_expression (expression) of UTR
10) Confidence 0.08 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0 Pain Relevance 0
Cortical neurons in culture were transfected with NLS-MS2-Venus, and an RNA localization reporter plasmid expressing BDNF-3'UTR fused to the binding sequence (MS2bs) of the bacteriophage MS2 protein.
Gene_expression (expressing) of UTR in neurons
11) Confidence 0.08 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0 Pain Relevance 0
g of a BDNF 3'UTR plasmid and 0.33 ?
Gene_expression (plasmid) of UTR
12) Confidence 0.07 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0.07 Pain Relevance 0.14
BDNF-3'UTR reporter plasmids
Gene_expression (plasmids) of UTR
13) Confidence 0.07 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0 Pain Relevance 0
The activity of the cadherin-11 (UTR) is regulated by Dicer
Gene_expression (activity) of UTR
14) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2650783 Disease Relevance 0 Pain Relevance 0
-UTR region of M6a (common to all isoforms of M6a); ii) primers specific for M6a isoform Ia; and iii) primers specific for M6a isoform Ib (Table 1; Fig. 1).
Gene_expression (region) of UTR
15) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2629568 Disease Relevance 0 Pain Relevance 0
UTR Ensembl but not luc-CDH11 3?
Neg (not) Gene_expression (luc) of UTR
16) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2650783 Disease Relevance 0 Pain Relevance 0
Constructs containing a 206-nucleotide 5'UTR were expressed poorly, whereas constructs from which most of the 5'UTR was removed were expressed well.
Gene_expression (expressed) of UTR
17) Confidence 0.02 Published 1991 Journal Mol. Pharmacol. Section Abstract Doc Link 1851958 Disease Relevance 0 Pain Relevance 0.50

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