INT168557

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Context Info
Confidence 0.44
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.87
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
nucleus 2
PFC 2
Bdnf (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 45 100.00 Very High Very High Very High
amygdala 5 100.00 Very High Very High Very High
depression 74 99.48 Very High Very High Very High
fluoxetine 19 85.92 High High
antidepressant 62 85.60 High High
Serotonin 2 84.64 Quite High
Endep 1 73.76 Quite High
vagus nerve 1 59.68 Quite High
mu opioid receptor 80 57.60 Quite High
Transcranial magnetic stimulation 3 56.80 Quite High
Disease Link Frequency Relevance Heat
Repression 16 100.00 Very High Very High Very High
Depression 96 99.48 Very High Very High Very High
Disease 4 98.30 Very High Very High Very High
Anxiety Disorder 9 92.64 High High
Targeted Disruption 11 81.16 Quite High
Affective Disorder 1 73.28 Quite High
Neurodegenerative Disease 3 69.72 Quite High
Suicidal Behaviour 123 5.00 Very Low Very Low Very Low
Stress 25 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 17 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, in contrast to white noise exposure, BDNF expression levels in the prefrontal cortex (PFC), amygdala and hippocampus were significantly increased in music-exposed adult BDNF(Met/Met) mice.
Positive_regulation (increased) of Negative_regulation (levels) of BDNF in PFC associated with hippocampus and amygdala
1) Confidence 0.44 Published 2010 Journal Brain Res. Section Abstract Doc Link 20515664 Disease Relevance 0.96 Pain Relevance 0.36
There was a negative correlation between increase in BDNF level and decrease in Hamilton Depression Rating Scale score.
Positive_regulation (increase) of Negative_regulation (decrease) of BDNF associated with depression
2) Confidence 0.40 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.15 Pain Relevance 0.36
In Huntington's disease, it has been proposed that mutant huntingtin led to accumulate the NRSF in nucleus, resulting in the strong repression of the BDNF which is controlled by NRSE (39).
Positive_regulation (resulting) of Negative_regulation (repression) of BDNF in nucleus associated with repression and disease
3) Confidence 0.12 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0.76 Pain Relevance 0.03

General Comments

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