INT168565

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Context Info
Confidence 0.13
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.74
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gc) transport (Gc) extracellular space (Gc)
extracellular region (Gc)
Gc (Mus musculus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 246 99.60 Very High Very High Very High
Angina 1 78.92 Quite High
Demyelination 6 27.32 Quite Low
Pain 2 11.12 Low Low
Inflammation 6 5.00 Very Low Very Low Very Low
intrathecal 4 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 3 99.84 Very High Very High Very High
Disease 40 99.78 Very High Very High Very High
Demyelinating Disease 252 99.60 Very High Very High Very High
Cardiovascular Disease 1 97.44 Very High Very High Very High
Neurological Disease 4 94.16 High High
Hypercalcemia 12 81.64 Quite High
Angina 1 78.92 Quite High
Muscle Weakness 4 58.80 Quite High
Disorder Of Lipid Metabolism 18 55.64 Quite High
Systemic Lupus Erythematosus 12 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another interesting differentially abundant protein is vitamin D-binding protein, which was not detected by mass spectrometry in the PP MScl samples but was detected in the RR MScl samples.
Neg (not) Positive_regulation (detected) of vitamin D-binding protein associated with multiple sclerosis
1) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.98 Pain Relevance 0.96
While our results do not indicate a differential abundance difference between the MScl subtypes and the controls, the two disease types did vary significantly in CSF levels of vitamin D-binding protein, with RR MScl showing a higher abundance.
Positive_regulation (vary) of vitamin D-binding protein associated with multiple sclerosis and disease
2) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.09 Pain Relevance 0.41
In 1997, the Institute of Medicine of the National Academy of Sciences made recommendations for vitamin D intake.
Positive_regulation (recommendations) of vitamin D
3) Confidence 0.05 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2902729 Disease Relevance 0 Pain Relevance 0
The participants were predosed with 800 IU of 25(OH)D on alternate days for an average of 3 weeks prior to calcium absorption measurements as a way to restore adequate vitamin D levels rapidly [4].
Positive_regulation (restore) of vitamin D
4) Confidence 0.05 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2902729 Disease Relevance 0.22 Pain Relevance 0
Proteomics reveals high levels of vitamin D binding protein in myocardial infarction.
Positive_regulation (levels) of vitamin D binding protein associated with myocardial infarction
5) Confidence 0.05 Published 2010 Journal Front Biosci (Elite Ed) Section Title Doc Link 20515752 Disease Relevance 0.45 Pain Relevance 0.08

General Comments

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