INT168600

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Context Info
Confidence 0.44
First Reported 2003
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 12.79
Pain Relevance 6.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp9) extracellular space (Mmp9) extracellular region (Mmp9)
proteinaceous extracellular matrix (Mmp9) extracellular matrix organization (Mmp9) protein complex (Mmp9)
Anatomy Link Frequency
cartilage 2
lung 2
spinal 1
cleavage 1
molar 1
Mmp9 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 487 100.00 Very High Very High Very High
Morphine 10 100.00 Very High Very High Very High
addiction 4 100.00 Very High Very High Very High
Inflammation 141 99.98 Very High Very High Very High
rheumatoid arthritis 62 97.68 Very High Very High Very High
fibrosis 171 97.60 Very High Very High Very High
withdrawal 6 96.48 Very High Very High Very High
Arthritis 18 95.60 Very High Very High Very High
allodynia 1 88.16 High High
cytokine 99 87.12 High High
Disease Link Frequency Relevance Heat
Pneumonia 100 100.00 Very High Very High Very High
Morphine Dependence 2 100.00 Very High Very High Very High
INFLAMMATION 156 99.98 Very High Very High Very High
Diabetes Mellitus 11 99.80 Very High Very High Very High
Bronchiectasis 2 99.40 Very High Very High Very High
Metastasis 8 99.32 Very High Very High Very High
Autoimmune Disease 10 98.92 Very High Very High Very High
Cancer 64 98.76 Very High Very High Very High
Interstitial Lung Diseases 17 98.68 Very High Very High Very High
Bacterial Infection 15 98.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MMP-9 has been associated with chronic inflammatory autoimmune diseases, including rheumatoid arthritis, Sjögren's syndrome, idiopathic uveitis, and systemic lupus erythematosus [16-19].
MMP-9 Binding (associated) of associated with autoimmune disease, inflammation, syndrome, rheumatoid arthritis, systemic lupus erythematosus and uveitis
1) Confidence 0.44 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064883 Disease Relevance 1.76 Pain Relevance 0.43
Our finding of a positive association between MMP-9 and diabetes fits in well with previous observations 5.
MMP-9 Binding (association) of associated with diabetes mellitus and metalloproteinase
2) Confidence 0.39 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1868659 Disease Relevance 1.09 Pain Relevance 0.53
Thus, we hypothesize that spinal MMP-9 may contribute to the development of morphine dependence primarily through neuronal activation and interaction with NR1 and NR2B receptors via integrin-beta1 and NO pathways.
spinal MMP-9 Binding (interaction) of in spinal associated with addiction and morphine
3) Confidence 0.32 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20519536 Disease Relevance 0.41 Pain Relevance 1.56
The absence of collagen deposition in KO mice seems to be associated with an elevated MMP-9/TIMP-1 ratio in the lungs.
MMP-9 Binding (associated) of in lungs
4) Confidence 0.32 Published 2005 Journal Respir Res Section Abstract Doc Link PMC548519 Disease Relevance 0.35 Pain Relevance 0.08
To determine the association of MMP-9 concentrations with a definite clinical manifestation of SSc, we compared the serum MMP-9 concentrations with clinical and laboratory characteristics in patients (n = 35) with SSc.
MMP-9 Binding (association) of associated with systemic sclerosis
5) Confidence 0.30 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064883 Disease Relevance 0.56 Pain Relevance 0
In the present study, we did not find any association between serum MMP-9 and the presence or severity of interstitial lung disease, even in a subgroup of SSc patients with diffuse or limited disease (data not shown).
serum MMP-9 Neg (not) Binding (association) of in lung associated with interstitial lung diseases, disease and systemic sclerosis
6) Confidence 0.29 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064883 Disease Relevance 1.26 Pain Relevance 0.22
The correlation of these levels with differences in hydroxyproline levels in the lungs of bleomycin-treated mice strongly suggests that a reduced molar pro-MMP-9/TIMP-1 ratio in BAL fluid is associated with collagen deposition, beginning as early as the inflammatory events at day 1 after bleomycin administration.
pro-MMP-9/TIMP-1 Binding (associated) of in molar associated with inflammation
7) Confidence 0.29 Published 2005 Journal Respir Res Section Body Doc Link PMC548519 Disease Relevance 0.95 Pain Relevance 0.32
Further, cooperation between MMP-9 and integrins is known to activate ?
MMP-9 Binding (cooperation) of
8) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904700 Disease Relevance 1.08 Pain Relevance 0
Zheng et al did show in bronchiectasis [26] neutrophil inflammation associated with MMP-8 and MMP-9 concentration.
MMP-9 Binding (associated) of in neutrophil associated with inflammation, bronchiectasis and metalloproteinase
9) Confidence 0.18 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2518539 Disease Relevance 1.35 Pain Relevance 0.98
Furthermore, recent studies have also indicated that L-arginine treatment decreases the activity of NF-kB and metalloproteinases MMP-2 and MMP-9, reduces beta-dystroglycan cleavage, and causes the translocations of utrophin and nNOS throughout the sarcolemma, thus promoting muscle membrane integrity and reducing fibrosis in dystrophic muscle [21].
MMP-9 Binding (metalloproteinases) of in cleavage associated with fibrosis and metalloproteinase
10) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888587 Disease Relevance 0.43 Pain Relevance 0.21
In line with these studies, we found in our study with HAP patients higher MMP-8 and MMP-9 BAL concentrations associated with significantly increased MMP-9 activity.
MMP-9 Binding (study) of associated with metalloproteinase and pneumonia
11) Confidence 0.16 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2518539 Disease Relevance 1.07 Pain Relevance 0.84
Our findings that GTH inhibit the activity of MMP-9 suggest the potential effect of GTH in mitigating the destruction of cartilage and inflammation of rheumatic diseases.
MMP-9 Neg (inhibit) Binding (activity) of in cartilage associated with inflammation, metalloproteinase and rheumatic diseases
12) Confidence 0.07 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2988746 Disease Relevance 1.60 Pain Relevance 0.68
The proteolytic activity at sites of synovial attachment to cartilage was found to be mediated by a complex consisting of MT1-MMP, tissue inhibitor of matrix metalloproteinase (TIMP)-2 and MMP-2, whereby TIMP-2 promotes the binding of pro-MMP-2 to MT1-MMP, by which it is subsequently activated [16].
pro-MMP-2 Binding (binding) of in cartilage associated with metalloproteinase
13) Confidence 0.04 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 0.80 Pain Relevance 0.64
into catheterized rhesus monkeys increases the activity of MMP-9 but not MMP-2 [48].
MMP-9 Neg (not) Binding (activity) of associated with metalloproteinase
14) Confidence 0.03 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305338 Disease Relevance 0.09 Pain Relevance 0.42

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