INT168602

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Context Info
Confidence 0.21
First Reported 2001
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.29
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itgb1) plasma membrane (Itgb1)
Anatomy Link Frequency
spinal 1
Itgb1 (Mus musculus)
Pain Link Frequency Relevance Heat
allodynia 1 99.22 Very High Very High Very High
withdrawal 5 98.28 Very High Very High Very High
Morphine 10 98.06 Very High Very High Very High
Dorsal horn 1 79.32 Quite High
rheumatoid arthritis 33 78.60 Quite High
addiction 4 76.96 Quite High
metalloproteinase 2 75.00 Quite High
Physical dependence 2 75.00 Quite High
narcan 2 67.88 Quite High
Spinal cord 1 63.80 Quite High
Disease Link Frequency Relevance Heat
Osteoporosis 18 99.60 Very High Very High Very High
Neuropathic Pain 1 99.22 Very High Very High Very High
Hypercalcemia 13 97.44 Very High Very High Very High
Congenital Anomalies 2 89.04 High High
Targeted Disruption 1 86.36 High High
Infection 49 81.48 Quite High
Rheumatoid Arthritis 33 78.60 Quite High
Morphine Dependence 2 77.68 Quite High
Drug Dependence 2 75.00 Quite High
Disease 7 74.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In these studies, we observed a significant decrease in the number of CD24(hi)CD29(?)
Negative_regulation (decrease) of CD29
1) Confidence 0.21 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 0.08 Pain Relevance 0
Further, spinal administration of exogenous MMP-9 induces morphine withdrawal-like behavioral signs and mechanical allodynia, activates NR1 and NR2 receptors, and downregulates integrin-beta1, while a function-neutralizing antibody against integrin-beta1 suppresses MMP-9-induced phosphorylation of NR1 and NR2B.
Negative_regulation (downregulates) of integrin-beta1 in spinal associated with allodynia, withdrawal and morphine
2) Confidence 0.02 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20519536 Disease Relevance 0.44 Pain Relevance 1.54
Therefore, inhibition of osteoclastic bone attachment by blocking integrin receptor is a potential therapeutic alternative that needs further studying.


Negative_regulation (blocking) of integrin receptor associated with osteoporosis
3) Confidence 0.01 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128900 Disease Relevance 0.78 Pain Relevance 0.18

General Comments

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