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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.32
Pain Relevance 2.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp9) extracellular space (Mmp9) extracellular region (Mmp9)
proteinaceous extracellular matrix (Mmp9) extracellular matrix organization (Mmp9) protein complex (Mmp9)
Anatomy Link Frequency
macrophages 2
Mmp9 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 53 100.00 Very High Very High Very High
withdrawal 5 99.98 Very High Very High Very High
Morphine 10 99.76 Very High Very High Very High
allodynia 1 91.64 High High
addiction 4 91.36 High High
corticosteroid 1 80.16 Quite High
Physical dependence 2 75.00 Quite High
Inflammatory mediators 8 73.36 Quite High
Dorsal horn 1 72.52 Quite High
tolerance 9 69.84 Quite High
Disease Link Frequency Relevance Heat
Neutropenia 1 99.90 Very High Very High Very High
Obesity 126 98.44 Very High Very High Very High
Stroke 81 98.08 Very High Very High Very High
Systemic Sclerosis 67 97.48 Very High Very High Very High
Morphine Dependence 2 92.08 High High
Neuropathic Pain 1 91.64 High High
Drug Dependence 2 75.00 Quite High
Disease 14 74.56 Quite High
INFLAMMATION 107 72.96 Quite High
Brain Injury 5 68.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine withdrawal-induced MMP-9 activity is also reduced by an nNOS inhibitor.
Negative_regulation (reduced) of Positive_regulation (induced) of MMP-9 associated with withdrawal and morphine
1) Confidence 0.37 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20519536 Disease Relevance 0.45 Pain Relevance 1.60
It seems unlikely that this discrepancy is attributable to a difference in the ELISA method (e.g. assay for total MMP-9 in this study versus active MMP-9 in the earlier report), because our patients showed a strong correlation between total MMP-9 and active MMP-9 in the additional test using the ELISA kit (R&D Systems; r = 0.745, P < 0.001; data not shown).
Negative_regulation (difference) of Positive_regulation (active) of MMP-9
2) Confidence 0.34 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064883 Disease Relevance 0.81 Pain Relevance 0.12
myel-mice exhibited drastically reduced MMP-9 activation compared to controls, possibly reflecting the reduced accumulation of macrophages in this compartment (Figure 6D and 6E).
Negative_regulation (reduced) of Spec (possibly) Positive_regulation (activation) of MMP-9 in macrophages associated with metalloproteinase
3) Confidence 0.27 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.37 Pain Relevance 0.48
Although complete neutropenia can reduce the increased levels of MMP-9 after transient MCAo, it cannot entirely abolish the upregulation after ischemic stroke [108].
Negative_regulation (reduce) of Positive_regulation (increased) of MMP-9 associated with neutropenia and stroke
4) Confidence 0.15 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2988764 Disease Relevance 0.69 Pain Relevance 0.21

General Comments

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