INT168609

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.41
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp9) extracellular space (Mmp9) extracellular region (Mmp9)
proteinaceous extracellular matrix (Mmp9) cell adhesion (Itgb1) plasma membrane (Itgb1)
Anatomy Link Frequency
spinal 1
Itgb1 (Mus musculus)
Mmp9 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 10 100.00 Very High Very High Very High
addiction 4 100.00 Very High Very High Very High
withdrawal 5 96.48 Very High Very High Very High
allodynia 1 88.16 High High
tolerance 2 87.36 High High
Opioid 3 79.28 Quite High
metalloproteinase 2 75.00 Quite High
Physical dependence 2 75.00 Quite High
Dorsal horn 1 69.04 Quite High
narcan 2 57.60 Quite High
Disease Link Frequency Relevance Heat
Morphine Dependence 2 100.00 Very High Very High Very High
Neuropathic Pain 1 88.16 High High
Drug Dependence 2 75.00 Quite High
Opiate Addiction 2 46.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, we hypothesize that spinal MMP-9 may contribute to the development of morphine dependence primarily through neuronal activation and interaction with NR1 and NR2B receptors via integrin-beta1 and NO pathways.
integrin-beta1 Binding (interaction) of spinal MMP-9 in spinal associated with addiction and morphine
1) Confidence 0.02 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20519536 Disease Relevance 0.41 Pain Relevance 1.58

General Comments

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