INT168614

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Context Info
Confidence 0.22
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.64
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Rps6ka1) nucleus (Rps6ka1) transcription factor binding (Rps6ka1)
cytoplasm (Rps6ka1)
Anatomy Link Frequency
ventral 1
Rps6ka1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Ventral tegmentum 7 97.44 Very High Very High Very High
Eae 1 70.08 Quite High
Dopamine 1 29.92 Quite Low
Pain 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Stress 9 99.78 Very High Very High Very High
Herpes Simplex Virus 1 86.64 High High
Nociception 1 66.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we show that acute (1 d) or chronic (4 weeks) exposure to unpredictable stress increases phosphorylation of ERK1/2 and of two downstream targets (ribosomal S6 kinase and mitogen- and stress-activated protein kinase 1) within the ventral tegmental area (VTA), an important substrate for motivated behavior and mood regulation.
Phosphorylation (phosphorylation) of ribosomal S6 kinase in ventral associated with stress and ventral tegmentum
1) Confidence 0.22 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20519540 Disease Relevance 0.64 Pain Relevance 0.21

General Comments

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