INT168624

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.39
First Reported 2007
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 6.49
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
liver 4
chondrocytes 2
endothelial cells 2
heart 2
ras (Mus musculus)
Pain Link Frequency Relevance Heat
depression 1 79.52 Quite High
Kinase C 48 76.32 Quite High
ketamine 4 29.28 Quite Low
anesthesia 2 10.00 Low Low
Nicotine 9 5.00 Very Low Very Low Very Low
palliative 3 5.00 Very Low Very Low Very Low
Immobilon 2 5.00 Very Low Very Low Very Low
Osteoarthritis 2 5.00 Very Low Very Low Very Low
Migraine 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Canker Sores 68 100.00 Very High Very High Very High
Nicotine Addiction 76 99.90 Very High Very High Very High
Cancer 239 99.84 Very High Very High Very High
Metastasis 241 99.00 Very High Very High Very High
Colon Cancer 246 98.66 Very High Very High Very High
Hyperplasia 9 87.52 High High
Lung Cancer 9 84.04 Quite High
Stress 2 80.40 Quite High
Depression 1 79.52 Quite High
Fibrosis 6 74.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, it is possible that higher mean age of smokers compared to non-smokers was responsible for the significantly lower prevalence of RAS in smokers reported in some studies that used only bivariate analysis.
Regulation (responsible) of Gene_expression (prevalence) of RAS associated with nicotine addiction and canker sores
1) Confidence 0.39 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2999509 Disease Relevance 2.02 Pain Relevance 0.04
However, the ontogeny of RAS expression during CRC liver metastases progression has not been described, nor have the effects of captopril treatment on RAS expression in tumors been documented.
Neg (nor) Regulation (effects) of Gene_expression (expression) of RAS in liver associated with cancer, colon cancer and metastasis
2) Confidence 0.36 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.59 Pain Relevance 0
A propensity score for RAS blockade was calculated for each subject using several factors: age, sex, serum creatinine, hypertension, heart disease, congestive heart failure, stroke, diabetes, and exposure to cardiovascular medications.
Regulation (calculated) of Gene_expression (blockade) of RAS in heart
3) Confidence 0.32 Published 2010 Journal Can J Anaesth Section Body Doc Link 20524103 Disease Relevance 0 Pain Relevance 0
Captopril treatment alters expression of the RAS in tumors
Regulation (alters) of Gene_expression (expression) of RAS associated with cancer
4) Confidence 0.31 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.35 Pain Relevance 0
These results demonstrate significant changes in RAS expression in the tumor-bearing captopril treated liver and in CRC metastases.
Regulation (changes) of Gene_expression (expression) of RAS in liver associated with cancer, colon cancer and metastasis
5) Confidence 0.16 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2860361 Disease Relevance 1.48 Pain Relevance 0
This observation is consistent with a previous study in which abrogation of Ras signaling by preventing the farnisylation of the protein did not affect VPA-mediated activation of Erk1/2 in endothelial cells [29].
Neg (not) Regulation (affect) of Gene_expression (abrogation) of Ras in endothelial cells
6) Confidence 0.03 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0 Pain Relevance 0.04
To investigate further the contribution of the MEK-1 pathway, we modulated the expression of Ras and Raf-1 proteins, which are known to trigger MEK-1 activation in chondrocytes [34].
Regulation (modulated) of Gene_expression (expression) of Ras in chondrocytes
7) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0.05 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox