INT168638

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Context Info
Confidence 0.65
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 5.15
Pain Relevance 2.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cx3cr1) plasma membrane (Cx3cr1) signal transducer activity (Cx3cr1)
Anatomy Link Frequency
macrophage 2
nerve 2
Cx3cr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 3 100.00 Very High Very High Very High
Inflammation 78 99.64 Very High Very High Very High
chemokine 96 95.60 Very High Very High Very High
Dorsal horn 1 93.76 High High
Thermal hyperalgesia 2 91.16 High High
allodynia 3 90.16 High High
Neuropathic pain 2 89.08 High High
Sciatic nerve 1 87.68 High High
Pain 4 87.12 High High
antagonist 6 82.56 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 1 99.98 Very High Very High Very High
INFLAMMATION 105 99.64 Very High Very High Very High
Injury 71 99.44 Very High Very High Very High
Asthma 88 98.68 Very High Very High Very High
Targeted Disruption 22 97.92 Very High Very High Very High
Infection 1 94.00 High High
Neuropathic Pain 7 93.52 High High
Necrosis 11 92.28 High High
Hyperalgesia 3 91.16 High High
Pain 5 87.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The fractalkine receptor (CX3CR1) showed expression levels that are increased by two-fold in bronchial tissues of subjects with normal pulmonary function in comparison with asthmatic subjects.
Positive_regulation (increased) of Gene_expression (expression) of CX3CR1 associated with asthma
1) Confidence 0.65 Published 2004 Journal BMC Genomics Section Body Doc Link PMC400730 Disease Relevance 0.72 Pain Relevance 0.17
In WT mice, inflammation and nerve injury increased spinal cord CX3CR1 and FKN expression.
Positive_regulation (increased) of Gene_expression (expression) of CX3CR1 in nerve associated with nervous system injury, inflammation and spinal cord
2) Confidence 0.50 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 20524966 Disease Relevance 2.29 Pain Relevance 1.32
In our I/R model, Cx3cr1 expression is significantly increased 7 days after injury, the peak moment of macrophage influx.
Positive_regulation (increased) of Gene_expression (expression) of Cx3cr1 in macrophage associated with injury
3) Confidence 0.43 Published 2010 Journal International Immunology Section Body Doc Link PMC2877810 Disease Relevance 1.04 Pain Relevance 0.10
TEPM expressed elevated levels of mRNA for Cxcr4, Ccr1, Ccrl2, whilst BMM expressed higher levels of Ccr2, Cx3cr1 and Cxcr3.
Positive_regulation (elevated) of Gene_expression (expressed) of Cx3cr1
4) Confidence 0.41 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.32 Pain Relevance 0.19
TEPM expressed elevated levels of mRNA for Cxcr4, Ccr1, Ccrl2, whilst BMM expressed higher levels of Ccr2, Cx3cr1 and Cxcr3.
Positive_regulation (levels) of Gene_expression (expressed) of Cx3cr1
5) Confidence 0.41 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.31 Pain Relevance 0.16
Conversely, the Ly6Clo and CD14/CD16+ subsets lack CCR2 but express high levels of CX3CR1 [2], [3], [14], [15].
Positive_regulation (levels) of Gene_expression (express) of CX3CR1
6) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.47 Pain Relevance 0.25

General Comments

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