INT168638

Context Info Confidence 0.65 First Reported 2004 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 6 Disease Relevance 5.15 Pain Relevance 2.19

signal transduction (Cx3cr1) plasma membrane (Cx3cr1) signal transducer activity (Cx3cr1)

Anatomy Link Frequency macrophage 2 nerve 2 Cx3cr1 (Mus musculus)

Pain Link Frequency Relevance Heat Spinal cord 3 100.00 Inflammation 78 99.64 chemokine 96 95.60 Dorsal horn 1 93.76 Thermal hyperalgesia 2 91.16 allodynia 3 90.16 Neuropathic pain 2 89.08 Sciatic nerve 1 87.68 Pain 4 87.12 antagonist 6 82.56

Disease Link Frequency Relevance Heat Nervous System Injury 1 99.98 INFLAMMATION 105 99.64 Injury 71 99.44 Asthma 88 98.68 Targeted Disruption 22 97.92 Infection 1 94.00 Neuropathic Pain 7 93.52 Necrosis 11 92.28 Hyperalgesia 3 91.16 Pain 5 87.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The fractalkine receptor (CX3CR1) showed expression levels that are increased by two-fold in bronchial tissues of subjects with normal pulmonary function in comparison with asthmatic subjects.

Positive_regulation (increased) of Gene_expression (expression) of CX3CR1 associated with asthma

1) Confidence 0.65 Published 2004 Journal BMC Genomics Section Body Doc Link PMC400730 Disease Relevance 0.72 Pain Relevance 0.17

In WT mice, inflammation and nerve injury increased spinal cord CX3CR1 and FKN expression.

Positive_regulation (increased) of Gene_expression (expression) of CX3CR1 in nerve associated with nervous system injury, inflammation and spinal cord

2) Confidence 0.50 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 20524966 Disease Relevance 2.29 Pain Relevance 1.32

In our I/R model, Cx3cr1 expression is significantly increased 7 days after injury, the peak moment of macrophage influx.

Positive_regulation (increased) of Gene_expression (expression) of Cx3cr1 in macrophage associated with injury

3) Confidence 0.43 Published 2010 Journal International Immunology Section Body Doc Link PMC2877810 Disease Relevance 1.04 Pain Relevance 0.10

TEPM expressed elevated levels of mRNA for Cxcr4, Ccr1, Ccrl2, whilst BMM expressed higher levels of Ccr2, Cx3cr1 and Cxcr3.

Positive_regulation (elevated) of Gene_expression (expressed) of Cx3cr1

4) Confidence 0.41 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.32 Pain Relevance 0.19

TEPM expressed elevated levels of mRNA for Cxcr4, Ccr1, Ccrl2, whilst BMM expressed higher levels of Ccr2, Cx3cr1 and Cxcr3.

Positive_regulation (levels) of Gene_expression (expressed) of Cx3cr1

5) Confidence 0.41 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.31 Pain Relevance 0.16

Conversely, the Ly6Clo and CD14/CD16+ subsets lack CCR2 but express high levels of CX3CR1 [2], [3], [14], [15].

Positive_regulation (levels) of Gene_expression (express) of CX3CR1

6) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.47 Pain Relevance 0.25

General Comments

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