INT168639

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Context Info
Confidence 0.57
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 8.57
Pain Relevance 3.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cx3cr1) plasma membrane (Cx3cr1) signal transducer activity (Cx3cr1)
Anatomy Link Frequency
monocyte 2
macrophages 1
spinal 1
neuronal 1
nerve 1
Cx3cr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 27 100.00 Very High Very High Very High
Inflammation 136 99.64 Very High Very High Very High
Lasting pain 5 97.36 Very High Very High Very High
chemokine 43 94.40 High High
dorsal root ganglion 9 93.84 High High
Dorsal horn 2 93.76 High High
Dorsal horn neuron 1 93.20 High High
Thermal hyperalgesia 4 91.16 High High
Pain 26 90.64 High High
allodynia 13 90.16 High High
Disease Link Frequency Relevance Heat
Nervous System Injury 34 99.98 Very High Very High Very High
INFLAMMATION 159 99.64 Very High Very High Very High
Multiple Sclerosis 181 99.56 Very High Very High Very High
Asthma 176 99.56 Very High Very High Very High
Targeted Disruption 71 97.92 Very High Very High Very High
Pain 36 97.36 Very High Very High Very High
Injury 17 96.76 Very High Very High Very High
Infection 4 94.00 High High
Ganglion Cysts 9 93.84 High High
Disease 74 93.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TEPM expressed elevated levels of mRNA for Cxcr4, Ccr1, Ccrl2, whilst BMM expressed higher levels of Ccr2, Cx3cr1 and Cxcr3.
Positive_regulation (levels) of Cx3cr1
1) Confidence 0.57 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.31 Pain Relevance 0.16
In WT mice, inflammation and nerve injury increased spinal cord CX3CR1 and FKN expression.
Positive_regulation (increased) of CX3CR1 in nerve associated with nervous system injury, inflammation and spinal cord
2) Confidence 0.50 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 20524966 Disease Relevance 2.28 Pain Relevance 1.31
In WT and Ccr2RFP/+Cx3cr1GFP/+ mice, equal numbers of F4/80+ monocyte/macrophages accumulated in the peritoneum (Figure 3B).
Positive_regulation (accumulated) of Cx3cr1GFP in macrophages
3) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.31 Pain Relevance 0.03
It is of great interest that the CX3CR1 receptor is expressed in spinal microglia and further upregulated after nerve injury [25,26].
Positive_regulation (upregulated) of CX3CR1 receptor in spinal associated with nervous system injury
4) Confidence 0.47 Published 2007 Journal Mol Pain Section Body Doc Link PMC2186318 Disease Relevance 1.17 Pain Relevance 0.76
Mature FKN is enzymatically cleaved from neuronal membranes and activation of its receptor, CX3CR1, which is expressed by microglia, induces phosphorylation of p38 MAPK.
Positive_regulation (activation) of CX3CR1 in neuronal
5) Confidence 0.46 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 20524966 Disease Relevance 1.43 Pain Relevance 0.76
The fractalkine receptor (CX3CR1) showed expression levels that are increased by two-fold in bronchial tissues of subjects with normal pulmonary function in comparison with asthmatic subjects.
Positive_regulation (increased) of CX3CR1 associated with asthma
6) Confidence 0.43 Published 2004 Journal BMC Genomics Section Body Doc Link PMC400730 Disease Relevance 0.72 Pain Relevance 0.17
The fractalkine receptor (CX3CR1) showed expression levels that are increased by two-fold in bronchial tissues of subjects with normal pulmonary function in comparison with asthmatic subjects.
Positive_regulation (increased) of fractalkine receptor associated with asthma
7) Confidence 0.43 Published 2004 Journal BMC Genomics Section Body Doc Link PMC400730 Disease Relevance 0.73 Pain Relevance 0.17
Conversely, the Ly6Clo and CD14/CD16+ subsets lack CCR2 but express high levels of CX3CR1 [2], [3], [14], [15].
Positive_regulation (levels) of CX3CR1
8) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.47 Pain Relevance 0.25
We previously showed that inflamed EAE tissues contain high levels of CCR2 and CX3CR1 ligands [26], [27], making this tissue ideal for comparing the trafficking properties of monocytes bearing either of the two cognate receptors.
Positive_regulation (levels) of CX3CR1 in monocytes associated with multiple sclerosis
9) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.83 Pain Relevance 0.03
In WT and Ccr2RFP/+Cx3cr1GFP/+ mice, equal numbers of F4/80+ monocyte/macrophages accumulated in the peritoneum (Figure 3B).
Positive_regulation (accumulated) of Cx3cr1GFP in monocyte
10) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.31 Pain Relevance 0.03

General Comments

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