INT168640

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Context Info
Confidence 0.33
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 8.30
Pain Relevance 4.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
dorsal horn 6
glial cells 2
middle cerebral artery 2
plaques 2
frontal cortex 2
Iba1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dorsal horn 52 99.98 Very High Very High Very High
Neurotransmitter 3 99.44 Very High Very High Very High
Peripheral nerve injury 5 97.88 Very High Very High Very High
spinal dorsal horn 24 97.64 Very High Very High Very High
Thermal hyperalgesia 11 97.36 Very High Very High Very High
Neuropathic pain 175 96.68 Very High Very High Very High
allodynia 25 96.36 Very High Very High Very High
imagery 67 95.96 Very High Very High Very High
Inflammation 13 94.88 High High
Sciatic nerve 15 93.88 High High
Disease Link Frequency Relevance Heat
Injury 146 99.72 Very High Very High Very High
Urological Neuroanatomy 5 99.32 Very High Very High Very High
Sprains And Strains 14 98.80 Very High Very High Very High
Targeted Disruption 135 98.60 Very High Very High Very High
Nervous System Injury 82 97.88 Very High Very High Very High
Hyperalgesia 25 97.36 Very High Very High Very High
Middle Cerebral Artery Infarction 2 97.32 Very High Very High Very High
Neuropathic Pain 224 96.68 Very High Very High Very High
INFLAMMATION 20 94.88 High High
Disease 128 93.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dorsal horn Iba1 immunostaining and phosphorylation of p38 MAPK increased after injury in WT controls but not in KO animals.
Neg (not) Positive_regulation (increased) of Gene_expression (immunostaining) of Iba1 in Dorsal horn associated with targeted disruption, injury and dorsal horn
1) Confidence 0.33 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 20524966 Disease Relevance 2.34 Pain Relevance 1.32
We also found that enhanced GFAP expression possibly reflecting astroglial activation and enhanced Iba 1 expression possibly reflecting microglial migration identified in L5 spinal dorsal horn from neuropathic mice were strongly suppressed in SNL-operated Cav2.2-/- mice.
Positive_regulation (enhanced) of Gene_expression (expression) of Iba 1 in dorsal horn associated with spinal dorsal horn and neuropathic pain
2) Confidence 0.21 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.91 Pain Relevance 0.72
Intriguingly, SNL-induced enhancements of GFAP- and Iba 1-IR were markedly suppressed in Cav2.2-/- mice (Figure 2Cii, 2Ciii, 2D and 2E).
Positive_regulation (enhancements) of Gene_expression (suppressed) of Iba 1
3) Confidence 0.21 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.50 Pain Relevance 0.33
We also found that enhanced GFAP expression possibly reflecting astroglial activation and enhanced Iba 1 expression possibly reflecting microglial migration identified in L5 spinal dorsal horn from neuropathic mice were strongly suppressed in SNL-operated Cav2.2-/- mice.
Positive_regulation (activation) of Gene_expression (expression) of Iba 1 in dorsal horn associated with spinal dorsal horn and neuropathic pain
4) Confidence 0.21 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.91 Pain Relevance 0.73
However, there was an increase in Iba-1 expression on the lesioned side of both strains one and two weeks after axotomy (Figures 1F, N, H and 1P).
Positive_regulation (increase) of Gene_expression (expression) of Iba-1 associated with sprains and strains
5) Confidence 0.19 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2885347 Disease Relevance 0.26 Pain Relevance 0.07
Long term upregulation of both IBA-1-ir and galectin-3/Mac-2-ir microglia has also been observed in the subventricular zone (SVZ) following middle cerebral artery occlusion [18].
Positive_regulation (upregulation) of Gene_expression (microglia) of IBA-1-ir in middle cerebral artery associated with middle cerebral artery infarction
6) Confidence 0.17 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2891720 Disease Relevance 0.73 Pain Relevance 0.15
Higher levels of IBA 1 expression was observed in frontal cortex of knock-in mouse.
Positive_regulation (levels) of Gene_expression (expression) of IBA 1 in frontal cortex associated with targeted disruption and urological neuroanatomy
7) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950155 Disease Relevance 1.07 Pain Relevance 0.13
For example, peripheral nerve injury produces profound changes in glial cells including morphological changes of microglia and astrocytes and increased expression of glial markers, such as CD11b, Iba-1 and GFAP [18].
Positive_regulation (increased) of Gene_expression (expression) of Iba-1 in glial cells associated with nervous system injury and peripheral nerve injury
8) Confidence 0.15 Published 2007 Journal Mol Pain Section Body Doc Link PMC2186318 Disease Relevance 0.87 Pain Relevance 0.90
For instance, the relationship between plaques (labeled with Methoxy-X04) and activated microglia (overexpressing GFP through an Iba-1 promoter) has recently been described in APPxPS1 transgenics [56].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of Iba-1 promoter in plaques
9) Confidence 0.03 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2952791 Disease Relevance 0.71 Pain Relevance 0.19

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