INT168641

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Context Info
Confidence 0.63
First Reported 2007
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 24
Total Number 24
Disease Relevance 12.21
Pain Relevance 6.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
microglia 3
Dorsal horn 2
gray matter 1
spinal cord 1
striatum 1
Iba1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dorsal horn 35 99.98 Very High Very High Very High
ischemia 43 99.44 Very High Very High Very High
Neurotransmitter 5 99.04 Very High Very High Very High
Pain 56 98.56 Very High Very High Very High
medulla 130 98.48 Very High Very High Very High
Spinal cord 290 98.32 Very High Very High Very High
cerebral cortex 18 97.76 Very High Very High Very High
Peripheral nerve injury 9 97.68 Very High Very High Very High
spinal dorsal horn 16 97.64 Very High Very High Very High
Thermal hyperalgesia 8 97.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 30 99.44 Very High Very High Very High
Urological Neuroanatomy 5 99.32 Very High Very High Very High
Sprains And Strains 15 98.80 Very High Very High Very High
Targeted Disruption 423 98.60 Very High Very High Very High
Pain 79 98.56 Very High Very High Very High
Injury 269 98.04 Very High Very High Very High
Nervous System Injury 101 97.68 Very High Very High Very High
Hyperalgesia 23 97.36 Very High Very High Very High
Middle Cerebral Artery Infarction 13 97.32 Very High Very High Very High
Neuropathic Pain 244 96.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Figure 4A, the expression level of Iba-1 was dramatically reduced in both the brainstem and spinal cord of BV-treated mice in comparison with the control group.
Gene_expression (expression) of Iba-1 in brainstem associated with medulla and spinal cord
1) Confidence 0.63 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2974667 Disease Relevance 0.45 Pain Relevance 0.42
After blocking in 5% normal goat serum at room temperature, sections were incubated with the primary antibodies, which included Iba-1 (Wako, Osaka, Japan) at 1:5000 or TNF-?
Gene_expression (included) of Iba-1
2) Confidence 0.55 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2974667 Disease Relevance 0 Pain Relevance 0.13
They were incubated for 48 h at RT in rabbit anti-IBA1 antibody (1?
Gene_expression (antibody) of IBA1
3) Confidence 0.53 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2970556 Disease Relevance 0.05 Pain Relevance 0.10
At a low magnification, Iba-1 immunoreactivity was detected in both the white and gray matter of the spinal cord in hSOD1G93A transgenic mice (Figure 4B,C).
Gene_expression (detected) of Iba-1 in gray matter associated with targeted disruption and spinal cord
4) Confidence 0.49 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2974667 Disease Relevance 0.42 Pain Relevance 0.45
Consistent with the morphology change of the microglia, the expression of Iba1 was dramatically up-regulated in the A53T mice as evidenced by quantitative RT-PCR and western blot analysis (see Additional file 7).
Gene_expression (expression) of Iba1 in microglia associated with targeted disruption
5) Confidence 0.48 Published 2010 Journal Mol Brain Section Body Doc Link PMC2873589 Disease Relevance 0.75 Pain Relevance 0.18
3 animals per condition; 50 IBA1-immunopositive processes each; Figure 4F; Table S1) and extracellular space area (p<0.05; n?
Gene_expression (processes) of IBA1-immunopositive
6) Confidence 0.46 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2970556 Disease Relevance 0 Pain Relevance 0
Areas of extracellular space apposing IBA1-positive microglia were found to be significantly larger (985±41 nm2; n?
Gene_expression (Areas) of IBA1 in microglia
7) Confidence 0.46 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2970556 Disease Relevance 0 Pain Relevance 0
Some PLD4 mRNA-expressing cells were also scattered within layer II–III of the cerebral cortex, the stratum-lacunosum-moleculare (sl-m) of the hippocampal CA1, and the inferior colliculus; these cells also expressed Iba1 protein, but not GFAP (Fig. 5B and C).
Neg (not) Gene_expression (expressed) of Iba1 in cerebral cortex associated with cerebral cortex
8) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978679 Disease Relevance 0 Pain Relevance 0.05
Dorsal horn Iba1 immunostaining and phosphorylation of p38 MAPK increased after injury in WT controls but not in KO animals.
Gene_expression (immunostaining) of Iba1 in Dorsal horn associated with targeted disruption, injury and dorsal horn
9) Confidence 0.45 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 20524966 Disease Relevance 2.31 Pain Relevance 1.30
Louis, MO), ionized calcium binding adaptor molecule-1 (Iba1, 1:1000, Wako Chemicals USA, Richmond, VA), tyrosine hydroxylase (TH, 1:1000, Pel-Freez Biologicals, Rogers, AR), ?
Gene_expression (1:1000) of Iba1
10) Confidence 0.42 Published 2010 Journal Mol Brain Section Body Doc Link PMC2873589 Disease Relevance 0 Pain Relevance 0.04
Double immunofluorescence staining was performed in sequential manner; primary antibody against Cp detection with Alexa488-conjugated goat anti-rabbit was followed by incubation of primary antibodies against CD31, GFAP, IBA1, or MAC-2 that were detected with immunoglobulin antibodies conjugated to Cy3.
Gene_expression (detected) of IBA1
11) Confidence 0.39 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.08 Pain Relevance 0.04
IBA-1 protein is expressed within both active and resting microglia [16].
Gene_expression (expressed) of IBA-1 in microglia
12) Confidence 0.30 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2891720 Disease Relevance 0.95 Pain Relevance 0
Iba-1-Positive microglias were expressed with Rab33b together in ischemic striatum (Figure 5B-b), but not in non-ischemic area (Figure 5B-a).


Neg (not) Gene_expression (expressed) of Iba-1-Positive in striatum
13) Confidence 0.28 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC3002892 Disease Relevance 0.64 Pain Relevance 0.32
Intriguingly, SNL-induced enhancements of GFAP- and Iba 1-IR were markedly suppressed in Cav2.2-/- mice (Figure 2Cii, 2Ciii, 2D and 2E).
Gene_expression (suppressed) of Iba 1
14) Confidence 0.28 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.50 Pain Relevance 0.31
We also found that enhanced GFAP expression possibly reflecting astroglial activation and enhanced Iba 1 expression possibly reflecting microglial migration identified in L5 spinal dorsal horn from neuropathic mice were strongly suppressed in SNL-operated Cav2.2-/- mice.
Gene_expression (expression) of Iba 1 in dorsal horn associated with spinal dorsal horn and neuropathic pain
15) Confidence 0.28 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.91 Pain Relevance 0.70
Higher levels of IBA 1 expression was observed in frontal cortex of knock-in mouse.
Gene_expression (expression) of IBA 1 in frontal cortex associated with targeted disruption and urological neuroanatomy
16) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950155 Disease Relevance 1.07 Pain Relevance 0.13
Semi-quantitative analysis of galectin-3/Mac-2 and IBA-1- immunoreactive cells
Gene_expression (analysis) of IBA-1
17) Confidence 0.26 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2891720 Disease Relevance 0 Pain Relevance 0
Semi-quantitative analysis of galectin-3/Mac-2 and IBA-1- immunoreactive cells
Gene_expression (/) of IBA-1
18) Confidence 0.26 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2891720 Disease Relevance 0 Pain Relevance 0
However, there was an increase in Iba-1 expression on the lesioned side of both strains one and two weeks after axotomy (Figures 1F, N, H and 1P).
Gene_expression (expression) of Iba-1 associated with sprains and strains
19) Confidence 0.24 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2885347 Disease Relevance 0.26 Pain Relevance 0.07
Long term upregulation of both IBA-1-ir and galectin-3/Mac-2-ir microglia has also been observed in the subventricular zone (SVZ) following middle cerebral artery occlusion [18].
Gene_expression (microglia) of IBA-1-ir in middle cerebral artery associated with middle cerebral artery infarction
20) Confidence 0.23 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2891720 Disease Relevance 0.68 Pain Relevance 0.15

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