INT168642

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Context Info
Confidence 0.77
First Reported 2004
Last Reported 2010
Negated 5
Speculated 0
Reported most in Body
Documents 15
Total Number 35
Disease Relevance 21.73
Pain Relevance 8.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cx3cr1) plasma membrane (Cx3cr1) signal transducer activity (Cx3cr1)
Anatomy Link Frequency
monocyte 7
macrophage 4
brain 4
microglia 3
T cells 2
Cx3cr1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 395 100.00 Very High Very High Very High
Spinal cord 79 99.98 Very High Very High Very High
Inflammation 721 99.20 Very High Very High Very High
antagonist 35 98.58 Very High Very High Very High
Neuropathic pain 126 98.08 Very High Very High Very High
cytokine 97 96.36 Very High Very High Very High
Lasting pain 9 96.24 Very High Very High Very High
Dorsal horn 2 92.88 High High
Pain 59 92.24 High High
dorsal root ganglion 18 90.32 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 317 99.88 Very High Very High Very High
Peritonitis 147 99.78 Very High Very High Very High
Nervous System Injury 66 99.54 Very High Very High Very High
Cystitis 70 99.52 Very High Very High Very High
Multiple Sclerosis 953 99.36 Very High Very High Very High
INFLAMMATION 821 99.20 Very High Very High Very High
Viral Meningitis 21 99.16 Very High Very High Very High
Age-related Macular Degeneration 36 98.76 Very High Very High Very High
Asthma 88 98.68 Very High Very High Very High
Injury 521 98.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In WT mice, inflammation and nerve injury increased spinal cord CX3CR1 and FKN expression.
Gene_expression (expression) of CX3CR1 in nerve associated with nervous system injury, inflammation and spinal cord
1) Confidence 0.77 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 20524966 Disease Relevance 2.27 Pain Relevance 1.31
Mature FKN is enzymatically cleaved from neuronal membranes and activation of its receptor, CX3CR1, which is expressed by microglia, induces phosphorylation of p38 MAPK.
Gene_expression (expressed) of CX3CR1 in neuronal
2) Confidence 0.77 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 20524966 Disease Relevance 1.46 Pain Relevance 0.77
To visualize the distribution of cells expressing GFP (CX3CR1) and RFP (CCR2), free-floating sections were stained with 15 nM DAPI for 5 min, and whole-brain sections were scanned using a Leica DM5500B with motorized x,y stage.
Gene_expression (expressing) of CX3CR1 in brain
3) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.70 Pain Relevance 0.03
For example, cell “1” in Fig. 6A is 7/4+, RFP+ and GFPdim, suggesting it is a Ly6Chi monocyte that expresses both CCR2 and CX3CR1.
Gene_expression (expresses) of CX3CR1 in monocyte
4) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.27 Pain Relevance 0.17
We created and characterized a transgenic mouse model that allows simultaneous tracking of two key chemokine receptors, CCR2 and CX3CR1 and enumeration of distinct monocyte and myeloid subsets based on CCR2-RFP/CX3CR1-GFP expression.
Gene_expression (expression) of CX3CR1-GFP in monocyte associated with targeted disruption and chemokine
5) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.41 Pain Relevance 0.11
First, by evaluating monocyte/macrophage/microglial chemokine receptor expression in EAE infiltrates, we found that CD45lo microglia invariably expressed CX3CR1 but not CCR2 in both healthy and diseased CNS tissues.
Neg (not) Gene_expression (expressed) of CX3CR1 in monocyte associated with chemokine and multiple sclerosis
6) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.69 Pain Relevance 0.08
Nonetheless, the ability to simultaneously image CCR2 and CX3CR1 expression in monocytes and other leukocytes represents a powerful new tool for investigating complex pathophysiology.
Gene_expression (expression) of CX3CR1 in leukocytes
7) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.48 Pain Relevance 0.10
The fractalkine receptor (CX3CR1) showed expression levels that are increased by two-fold in bronchial tissues of subjects with normal pulmonary function in comparison with asthmatic subjects.
Gene_expression (expression) of CX3CR1 associated with asthma
8) Confidence 0.72 Published 2004 Journal BMC Genomics Section Body Doc Link PMC400730 Disease Relevance 0.72 Pain Relevance 0.17
subsets [14] express chemokine receptor 2 (CCR2) and low levels of CX3CR1 [2] and appear to be functionally equivalent across species.
Gene_expression (express) of CX3CR1 associated with chemokine
9) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.42 Pain Relevance 0.23
Conversely, the Ly6Clo and CD14/CD16+ subsets lack CCR2 but express high levels of CX3CR1 [2], [3], [14], [15].
Gene_expression (express) of CX3CR1
10) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.47 Pain Relevance 0.25
To visualize CX3CR1-and CCR2-expressing cells in the brains of Ccr2RFP/+Cx3cr1GFP/+ and Ccr2RFP/RFPCx3cr1GFP/+ mice, we used fluorescence microscopy.
Gene_expression (-) of CX3CR1 in brains
11) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.22 Pain Relevance 0
CD45lo microglial cells were CCR2-RFP negative at EAE peak severity and had the highest level of CX3CR1 expression.
Gene_expression (expression) of CX3CR1 in microglial cells associated with multiple sclerosis
12) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.32 Pain Relevance 0.03
After instillation of thioglycollate for 24 h to induce peritonitis, Ccr2RFP/+Cx3cr1GFP/+ F4/80dim monocytes were actively recruited to the peritoneum, and almost all expressed high levels of both RFP and GFP (Figure 3A).
Gene_expression (expressed) of Cx3cr1GFP in peritoneum associated with peritonitis
13) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.25 Pain Relevance 0
Thus, the diversity of the mononuclear myeloid cell infiltrate in EAE is mirrored by a population-specific pattern of CCR2 and CX3CR1 expression, suggesting that the Ly6Chi/CCR2+ and Ly6Clo/CX3CR1+ subsets retain functional specialization in the inflamed CNS.


Gene_expression (expression) of CX3CR1 in myeloid cell associated with multiple sclerosis
14) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.25 Pain Relevance 0
TEPM expressed elevated levels of mRNA for Cxcr4, Ccr1, Ccrl2, whilst BMM expressed higher levels of Ccr2, Cx3cr1 and Cxcr3.
Gene_expression (expressed) of Cx3cr1
15) Confidence 0.63 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.31 Pain Relevance 0.16
The fractalkine receptor (CX3CR1) is expressed on natural killer (NK) cells, monocytes, and some CD8+ T cells [18].
Gene_expression (expressed) of fractalkine receptor in T cells
16) Confidence 0.60 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 0.66 Pain Relevance 0.63
The fractalkine receptor (CX3CR1) is expressed on natural killer (NK) cells, monocytes, and some CD8+ T cells [18].
Gene_expression (expressed) of CX3CR1 in T cells
17) Confidence 0.60 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 0.66 Pain Relevance 0.62
As previously shown by co-localization with the microglial marker iba-1 [28], CX3CR1-GFP was present in microglial cells throughout the brain in both healthy and diseased tissue (Figure 5A–F).
Gene_expression (present) of CX3CR1-GFP in brain
18) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.30 Pain Relevance 0.04
The relative expression of CX3CR1-GFP and CCR2-RFP allowed us for the first time to distinguish monocyte/macrophage subsets and discriminate between resident microglia and infiltrating monocyte-derived macrophages in the brain.


Gene_expression (expression) of CX3CR1-GFP in monocyte
19) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.67 Pain Relevance 0.12
To evaluate blood monocyte subsets for expression of CCR2 or CX3CR1 during chronic systemic inflammation, we crossed Ccr2RFP/RFP mice with Cx3cr1GFP/GFP mice [23] and examined Ccr2RFP/+Cx3cr1GFP/+Apoe?
Gene_expression (expression) of CX3CR1 in monocyte associated with inflammation
20) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.18 Pain Relevance 0.05

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