INT168658

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Context Info
Confidence 0.44
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.11
Pain Relevance 2.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR1B) cytoplasm (HTR1B) signal transducer activity (HTR1B)
Anatomy Link Frequency
suprachiasmatic nucleus 2
HTR1B (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 52 100.00 Very High Very High Very High
Neuropeptide 3 100.00 Very High Very High Very High
Serotonin 78 99.96 Very High Very High Very High
monoamine 26 99.24 Very High Very High Very High
depression 82 98.16 Very High Very High Very High
noradrenaline 50 88.96 High High
Neurotransmitter 4 71.12 Quite High
antidepressant 70 39.44 Quite Low
Pain 4 32.64 Quite Low
Dopamine 24 26.80 Quite Low
Disease Link Frequency Relevance Heat
Aging 5 100.00 Very High Very High Very High
Depression 96 98.16 Very High Very High Very High
Depressive Disorder 6 71.64 Quite High
Disease 10 68.28 Quite High
Stress 18 60.32 Quite High
Suicidal Behaviour 2 53.80 Quite High
Major Depressive Disorder 54 50.56 Quite High
Congenital Anomalies 4 28.16 Quite Low
Cognitive Disorder 6 27.60 Quite Low
Constipation 10 20.24 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Decreased sensitivity of 5-HT1A and 5-HT1B autoreceptors, which regulate serotonin function, has been associated with depression.13,14 In contrast, the sensitivity of ?
Regulation (regulate) of Gene_expression (autoreceptors) of 5-HT1B associated with depression and serotonin
1) Confidence 0.44 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938284 Disease Relevance 0.94 Pain Relevance 0.91
Decreased sensitivity of 5-HT1A and 5-HT1B autoreceptors, which regulate serotonin function, has been associated with depression.13,14 In contrast, the sensitivity of ?
Regulation (sensitivity) of Gene_expression (autoreceptors) of 5-HT1B associated with depression and serotonin
2) Confidence 0.44 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938284 Disease Relevance 0.90 Pain Relevance 0.92
The effects of aging and chronic fluoxetine treatment on circadian rhythms and suprachiasmatic nucleus expression of neuropeptide genes and 5-HT1B receptors.
Regulation (effects) of Gene_expression (expression) of 5-HT1B in suprachiasmatic nucleus associated with aging, neuropeptide and fluoxetine
3) Confidence 0.26 Published 2010 Journal Eur. J. Neurosci. Section Title Doc Link 20525077 Disease Relevance 0.27 Pain Relevance 0.61

General Comments

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