INT168677

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Context Info
Confidence 0.27
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 6.29
Pain Relevance 3.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ACOT1) lipid metabolic process (ACOT1) cytoplasm (ACOT1)
Anatomy Link Frequency
plasma 1
cholinergic neurons 1
neuronal 1
brain 1
striated muscles 1
ACOT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
sSRI 7 99.98 Very High Very High Very High
adenocard 350 99.90 Very High Very High Very High
bradykinin 28 99.88 Very High Very High Very High
Clonidine 13 99.88 Very High Very High Very High
5HT 25 99.52 Very High Very High Very High
cerebral cortex 14 97.76 Very High Very High Very High
cva 55 97.60 Very High Very High Very High
fluoxetine 6 95.96 Very High Very High Very High
tricyclic antidepressant 2 95.64 Very High Very High Very High
Neurotransmitter 21 83.44 Quite High
Disease Link Frequency Relevance Heat
Sleep Disorders 729 99.44 Very High Very High Very High
Muscular Spasm 8 99.36 Very High Very High Very High
Increased Venous Pressure Under Development 48 99.00 Very High Very High Very High
Cv General 3 Under Development 55 97.60 Very High Very High Very High
Targeted Disruption 17 96.82 Very High Very High Very High
Dilated Cardiomyopathy 80 95.96 Very High Very High Very High
Disease 91 95.32 Very High Very High Very High
Cognitive Disorder 152 91.92 High High
Myasthenia Gravis 168 88.92 High High
Neurodegenerative Disease 2 84.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Acetylcholine was infused into the LAD via the infusion catheter at 5 mL/min for 2 min in the following order: (i) three 2-min infusions of ACh at 0.15, 1.5, and 15 µg/min, yielding estimated intracoronary concentrations of 10?
Negative_regulation (infusions) of ACh
1) Confidence 0.27 Published 2010 Journal European Heart Journal Section Body Doc Link PMC2995954 Disease Relevance 0 Pain Relevance 0
Figure 3 shows representative tracings of the change in plasma NO concentration in the GCV after intracoronary infusion of ACh at different concentrations (0.3, 3, and 30 µg) and infusion of ACh immediately after l-NMMA in the DCM and control groups.
Negative_regulation (infusion) of ACh in plasma associated with dilated cardiomyopathy
2) Confidence 0.27 Published 2010 Journal European Heart Journal Section Body Doc Link PMC2995954 Disease Relevance 0.51 Pain Relevance 0
For concomitant infusion of clonidine, the inhibition of Ach-, BK-, and 5HT-mediated vasodilatation was 48 ± 18%, 45 ± 12%, and 40 ± 12%, respectively (p < 0.05 for all compared with saline) (see Figure 1), whereas it was 65 ± 12%, 34 ± 10% and 44 ± 8% for concomitant infusion with L-NMMA (p < 0.05 for all compared with saline) (see Figure 1).


Negative_regulation (inhibition) of Ach associated with 5ht, increased venous pressure under development, bradykinin and clonidine
3) Confidence 0.27 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993953 Disease Relevance 0.10 Pain Relevance 0.54
In conclusion, SSRIs inhibit the most important neuronal AChRs with potencies and affinities that are clinically relevant by binding to a luminal site that is shared with tricyclic antidepressants.
Negative_regulation (inhibit) of AChRs in neuronal associated with tricyclic antidepressant and ssri
4) Confidence 0.11 Published 2010 Journal Biochemistry Section Abstract Doc Link 20527991 Disease Relevance 0 Pain Relevance 0.66
Thus, deficiency of both basal and ACh-induced NO activity in spasm arteries in patients with vasospastic angina is quite possible.33-35)
Negative_regulation (deficiency) of ACh-induced associated with muscular spasm and cva
5) Confidence 0.08 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2801457 Disease Relevance 1.05 Pain Relevance 0.24
These compounds, known as acetylcholinesterase inhibitors (AChEIs), inhibit the cholinesterases and aim at improving the brain synaptic availability of acetylcholine.
Negative_regulation (inhibitors) of AChEIs in brain
6) Confidence 0.07 Published 2007 Journal Current Genomics Section Abstract Doc Link PMC2647161 Disease Relevance 0.73 Pain Relevance 0.04
Likewise, a reduced ACh level during SD would thus deteriorate perceptual processing and thereby place a higher burden on PFC, consistent with the notion of the compensatory role of PFC during SD [108].
Negative_regulation (reduced) of ACh associated with sleep disorders
7) Confidence 0.07 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2778638 Disease Relevance 0.42 Pain Relevance 0.20
The effects of SD on N1 and P300 could thus be an effect of reduced cortical ACh levels caused by inhibition of the cholinergic neurons by AD.
Negative_regulation (reduced) of ACh in cholinergic neurons associated with adenocard and sleep disorders
8) Confidence 0.06 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2778638 Disease Relevance 0.22 Pain Relevance 0.15
Similarly, the ‘cat P300’ disappeared after septal lesions, and the lesioned cats were characterized by marked ACh depletion [150].
Negative_regulation (depletion) of ACh
9) Confidence 0.06 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2778638 Disease Relevance 0.21 Pain Relevance 0.12
In sum, the effects of increased AD and decreased ACh levels match the macroscopic effects of SD, such as the reduced ERP components and changes in EEG rhythms.
Negative_regulation (decreased) of ACh associated with adenocard and sleep disorders
10) Confidence 0.06 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2778638 Disease Relevance 0.54 Pain Relevance 0.45
In particular, the inhibition of the cholinergic nuclei results in reduced cortical levels of (ACh), which have been shown to result in similar macroscopic effects as SD.
Negative_regulation (reduced) of ACh associated with sleep disorders
11) Confidence 0.06 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2778638 Disease Relevance 0.44 Pain Relevance 0.49
Second, reduced cortical ACh levels result in the attention-related effects on the amplitude of ERP/ERF components, such as the N1 and P300.
Negative_regulation (reduced) of ACh
12) Confidence 0.06 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2778638 Disease Relevance 0.22 Pain Relevance 0.12
Although some of these studies were not carried out for the purpose of investigating the effects of SD, we will discuss part of this literature showing that the decrease in ACh and the increase in AD results in similar effects as SD.
Negative_regulation (decrease) of ACh associated with adenocard and sleep disorders
13) Confidence 0.04 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2778638 Disease Relevance 0.45 Pain Relevance 0.42
The functional loss of AChRs reduces the probability of successful neuromuscular transmission following quantal release of acetylcholine by the motor nerve terminal, resulting in clinical weakness in striated muscles.
Negative_regulation (loss) of AChRs in striated muscles
14) Confidence 0.01 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2211463 Disease Relevance 1.13 Pain Relevance 0.08
Transgenic expression of WT ser-4 gene rescued 5-HT sensitivity of the ser-4(ok512) mutant (Figure 9a), indicating that SER-4 function is required for exogenous 5-HT to downregulate ACh neurotransmission.
Negative_regulation (downregulate) of ACh associated with targeted disruption
15) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860991 Disease Relevance 0.26 Pain Relevance 0

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