INT16868

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Context Info
Confidence 0.78
First Reported 1990
Last Reported 2011
Negated 8
Speculated 27
Reported most in Abstract
Documents 807
Total Number 835
Disease Relevance 499.48
Pain Relevance 256.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) aging (Il6) extracellular region (Il6)
Anatomy Link Frequency
plasma 44
blood 23
macrophage 20
monocyte 17
brain 16
Il6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 5793 100.00 Very High Very High Very High
cytokine 3965 100.00 Very High Very High Very High
cva 849 100.00 Very High Very High Very High
Pain 660 100.00 Very High Very High Very High
dorsal root ganglion 561 100.00 Very High Very High Very High
antagonist 539 100.00 Very High Very High Very High
Spinal cord 365 100.00 Very High Very High Very High
Inflammatory mediators 355 100.00 Very High Very High Very High
Inflammatory marker 353 100.00 Very High Very High Very High
allodynia 195 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 7060 100.00 Very High Very High Very High
Cancer 833 100.00 Very High Very High Very High
Neuropathic Pain 764 100.00 Very High Very High Very High
Ganglion Cysts 583 100.00 Very High Very High Very High
Fat Embolism 562 100.00 Very High Very High Very High
Nervous System Injury 460 100.00 Very High Very High Very High
Necrosis 447 100.00 Very High Very High Very High
Pressure And Volume Under Development 425 100.00 Very High Very High Very High
Adhesions 286 100.00 Very High Very High Very High
Hyperalgesia 207 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The cellular localization of the IL-6 mRNA expression was predominately neuronal as confirmed by NeuN serial staining.
Gene_expression (expression) of IL-6 mRNA in neuronal
1) Confidence 0.78 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9813345 Disease Relevance 0.66 Pain Relevance 0.72
In the current study, our objective was to determine if the source of IL-6 protein was endogenous to the central nervous system by measuring any detectable increases in spinal IL-6 mRNA expression following established mononeuropathy procedures associated with neuropathic pain: spinal nerve cryoneurolysis (SPCN) or spinal nerve tight ligation (SPTL).
Gene_expression (expression) of IL-6 mRNA in spinal nerve associated with neuropathic pain, central nervous system and diabetic nephropathy
2) Confidence 0.78 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9813345 Disease Relevance 0.68 Pain Relevance 0.62
The most likely cause of the raised IL-6 levels in the implant groups is fat embolism as the only difference between them and the control group was the fat seen on lung histology.
Gene_expression (levels) of IL-6 in lung associated with cva and fat embolism
3) Confidence 0.78 Published 2009 Journal J Orthop Surg Res Section Body Doc Link PMC2702344 Disease Relevance 0.22 Pain Relevance 0.26
We observed that minocycline which was reported to have a neuroprotective effect in some neurodegenerative diseases, reversed hyperalgesia and allodynia due to sciatic nerve ligation and inhibited the interleukin-6 production.
Gene_expression (production) of interleukin-6 in sciatic nerve associated with hyperalgesia, allodynia, sciatic nerve and neurodegenerative disease
4) Confidence 0.78 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16687137 Disease Relevance 0.89 Pain Relevance 1.01
Interleukin-6-mediated hyperalgesia/allodynia and increased spinal IL-6 expression in a rat mononeuropathy model.
Gene_expression (expression) of IL-6 in spinal associated with hyperalgesia, allodynia and diabetic nephropathy
5) Confidence 0.78 Published 1996 Journal J. Interferon Cytokine Res. Section Title Doc Link 8887053 Disease Relevance 0.78 Pain Relevance 0.75
To further address this concept, the immunoreactive spinal expression of the pro-inflammatory cytokine, interleukin-6 (IL-6), was determined in the mononeuropathy model in the rat, sciatic cryoneurolysis (SCN).
Gene_expression (expression) of interleukin-6 in spinal associated with inflammation, diabetic nephropathy and cytokine
6) Confidence 0.78 Published 1996 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 8887053 Disease Relevance 0.61 Pain Relevance 0.54
To further address this concept, the immunoreactive spinal expression of the pro-inflammatory cytokine, interleukin-6 (IL-6), was determined in the mononeuropathy model in the rat, sciatic cryoneurolysis (SCN).
Gene_expression (expression) of IL-6 in spinal associated with inflammation, diabetic nephropathy and cytokine
7) Confidence 0.78 Published 1996 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 8887053 Disease Relevance 0.66 Pain Relevance 0.59
Hyperthermia significantly increased the production of IL-6 (p = 0.049) but not IL-1beta and significantly increased mortality.
Gene_expression (production) of IL-6 associated with fever
8) Confidence 0.78 Published 2002 Journal Pediatr. Res. Section Abstract Doc Link 12438666 Disease Relevance 0.70 Pain Relevance 0.27
Administration of MDP significantly increased the IL-1beta production (p = 0.006) but not IL-6.
Gene_expression (production) of IL-6
9) Confidence 0.78 Published 2002 Journal Pediatr. Res. Section Abstract Doc Link 12438666 Disease Relevance 0.58 Pain Relevance 0.23
With the aim of elucidating the physiopathological mechanisms underlying cephalic versus extracephalic neuropathic pain, we determined the time course expression of proinflammatory cytokines interleukin-6 (IL-6) and IL-1beta, neuronal injury (ATF3), macrophage/microglial (OX-42), and satellite cells/astrocyte (GFAP) markers in central and ganglion tissues in rats that underwent unilateral chronic constriction injury (CCI) to either infraorbital nerve (IoN) (cephalic area) or sciatic nerve (SN) (extracephalic area).
Spec (determined) Gene_expression (expression) of interleukin-6 in macrophage associated with ganglion cysts, eae, injury, neuropathic pain, sciatic nerve and cytokine
10) Confidence 0.77 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18716207 Disease Relevance 0.99 Pain Relevance 0.67
With the aim of elucidating the physiopathological mechanisms underlying cephalic versus extracephalic neuropathic pain, we determined the time course expression of proinflammatory cytokines interleukin-6 (IL-6) and IL-1beta, neuronal injury (ATF3), macrophage/microglial (OX-42), and satellite cells/astrocyte (GFAP) markers in central and ganglion tissues in rats that underwent unilateral chronic constriction injury (CCI) to either infraorbital nerve (IoN) (cephalic area) or sciatic nerve (SN) (extracephalic area).
Spec (determined) Gene_expression (expression) of IL-6 in macrophage associated with ganglion cysts, eae, injury, neuropathic pain, sciatic nerve and cytokine
11) Confidence 0.77 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18716207 Disease Relevance 1.00 Pain Relevance 0.67
The interleukin-6 (IL-6) over-production can either be ascribed directly to the tumor (as confirmed by immunohistochemistry) or indirectly accounted for by tumoral production, as a consequence of the high levels of circulating norepinephrine.
Gene_expression (production) of interleukin-6 associated with cancer
12) Confidence 0.77 Published 2003 Journal J. Endocrinol. Invest. Section Abstract Doc Link 12906374 Disease Relevance 1.00 Pain Relevance 0.42
The interleukin-6 (IL-6) over-production can either be ascribed directly to the tumor (as confirmed by immunohistochemistry) or indirectly accounted for by tumoral production, as a consequence of the high levels of circulating norepinephrine.
Gene_expression (production) of IL-6 associated with cancer
13) Confidence 0.77 Published 2003 Journal J. Endocrinol. Invest. Section Abstract Doc Link 12906374 Disease Relevance 1.00 Pain Relevance 0.42
Interleukin-6 producing pheochromocytoma presenting with acute inflammatory syndrome.
Gene_expression (producing) of Interleukin-6 associated with inflammation, syndrome and pheochromocytoma
14) Confidence 0.77 Published 2003 Journal J. Endocrinol. Invest. Section Title Doc Link 12906374 Disease Relevance 1.09 Pain Relevance 0.44
Although there was no weight gain or improvement in hypoalbuminemia, these results suggest that steroids may suppress the abnormal production of IL-6 in cancer patients and that this action affects symptoms.
Gene_expression (production) of IL-6 associated with cancer, hypoalbuminemia and weight gain
15) Confidence 0.77 Published 1996 Journal J Pain Symptom Manage Section Abstract Doc Link 8803383 Disease Relevance 0.72 Pain Relevance 0.16
Palliative steroid therapy and serum interleukin-6 levels in a patient with lung cancer.
Gene_expression (levels) of interleukin-6 in lung associated with lung cancer and palliative
16) Confidence 0.77 Published 1996 Journal J Pain Symptom Manage Section Title Doc Link 8803383 Disease Relevance 0.69 Pain Relevance 0.19
Serum IL-6 levels correlate with the patient's clinical course during and after coronary artery bypass.
Gene_expression (levels) of IL-6 in coronary artery
17) Confidence 0.77 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9706914 Disease Relevance 0 Pain Relevance 0.43
Further study is warranted to clarify the role of IL-6 in tumor-related symptoms and the effect of steroid therapy in relation to IL-6 production in cancer patients.
Gene_expression (production) of IL-6 associated with cancer
18) Confidence 0.77 Published 1996 Journal J Pain Symptom Manage Section Abstract Doc Link 8803383 Disease Relevance 0.78 Pain Relevance 0.16
Several lines of evidence obtained in the laboratory have shown that the brain significantly modulates IL-6 production in the periphery.
Gene_expression (production) of IL-6 in brain
19) Confidence 0.77 Published 1998 Journal Neuroimmunomodulation Section Abstract Doc Link 9730688 Disease Relevance 0.79 Pain Relevance 0.14
Serum levels of interleukin-6 (IL-6) and of hormones (sex, thyroid, and calciotropic), vertebral mobility (Schober test), daily physical activity, and treatment administered were recorded every 6 months for all patients.
Gene_expression (levels) of IL-6 in thyroid
20) Confidence 0.77 Published 1999 Journal Arthritis Rheum. Section Body Doc Link 10555026 Disease Relevance 0.16 Pain Relevance 0

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