INT168683

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Context Info
Confidence 0.12
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.61
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGA4) plasma membrane (ITGA4)
Anatomy Link Frequency
neuron 1
ITGA4 (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 3 99.24 Very High Very High Very High
Pain 5 98.48 Very High Very High Very High
Nav1.7 6 93.72 High High
Congenital analgesia 1 88.12 High High
nav1.8 3 85.64 High High
hyperexcitability 2 81.08 Quite High
Eae 6 5.00 Very Low Very Low Very Low
Neuritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 5 98.48 Very High Very High Very High
Syndrome 1 90.12 High High
Congenital Pain Insensitivity 1 88.12 High High
Repression 30 5.00 Very Low Very Low Very Low
Targeted Disruption 22 5.00 Very Low Very Low Very Low
Sprains And Strains 14 5.00 Very Low Very Low Very Low
Neuritis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of ranolazine on wild-type and mutant hNav1.7 channels and on DRG neuron excitability.
Localization (excitability) of wild-type in neuron
1) Confidence 0.12 Published 2010 Journal Mol Pain Section Title Doc Link 20529343 Disease Relevance 0.61 Pain Relevance 1.40
These events most likely involve the reciprocal regulation of the phosphorylation status of PER by DBT and CKII, whereby CKII function seems crucially important for efficient nuclear localization of PER in wild-type flies [20,32,33,41].
Localization (localization) of wild-type
2) Confidence 0.01 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2671555 Disease Relevance 0 Pain Relevance 0
These events most likely involve the reciprocal regulation of the phosphorylation status of PER by DBT and CKII, whereby CKII function seems crucially important for efficient nuclear localization of PER in wild-type flies [20,32,33,41].
Localization (localization) of wild-type
3) Confidence 0.01 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2671555 Disease Relevance 0 Pain Relevance 0

General Comments

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