INT16869

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Context Info
Confidence 0.70
First Reported 1987
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 24
Total Number 26
Disease Relevance 15.70
Pain Relevance 7.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Prl)
Anatomy Link Frequency
Thyroid 2
mammary gland 1
plasma 1
pituitary 1
Prl (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 7 100.00 Very High Very High Very High
Inflammatory mediators 1 100.00 Very High Very High Very High
Glutamate 9 99.78 Very High Very High Very High
cannabis 1 99.76 Very High Very High Very High
Inflammation 186 99.70 Very High Very High Very High
Morphine 8 99.54 Very High Very High Very High
Central nervous system 91 99.36 Very High Very High Very High
Dismenorea 37 99.30 Very High Very High Very High
methadone 1 99.30 Very High Very High Very High
Nerve growth factor 6 99.18 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 188 100.00 Very High Very High Very High
Cancer 504 99.64 Very High Very High Very High
Dysmenorrhea 37 99.30 Very High Very High Very High
Recurrence 88 98.84 Very High Very High Very High
Sprains And Strains 125 98.48 Very High Very High Very High
Multiple Sclerosis 663 96.56 Very High Very High Very High
Muscle Weakness 1 96.36 Very High Very High Very High
Reprotox - General 3 8 95.68 Very High Very High Very High
Skin Atrophy 1 95.68 Very High Very High Very High
Gynecomastia 1 95.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Subcutaneous implantation of RU 486, an antiprogesterone, enhanced preneoplastic and neoplastic mammary gland growth in SHN virgin mice associated with elevated plasma prolactin levels and continued vaginal oestrous stage.
Positive_regulation (elevated) of prolactin in mammary gland
1) Confidence 0.70 Published 1989 Journal Anticancer Res. Section Abstract Doc Link 2817809 Disease Relevance 0.24 Pain Relevance 0.28
A mouse model, in which ectopic pituitary isografting is associated with an increase in the plasma level of prolactin, is useful for a rapid and frequent induction of uterine adenomyosis and can be used to study the origin of this lesion.
Positive_regulation (increase) of prolactin in plasma associated with dismenorea
2) Confidence 0.70 Published 1991 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 1853904 Disease Relevance 0.87 Pain Relevance 0.42
Administration of these drugs twice daily for 40-70 or 40-90 days of age induced an elevation in serum level of prolactin.
Positive_regulation (elevation) of prolactin
3) Confidence 0.70 Published 1991 Journal Life Sci. Section Abstract Doc Link 2062175 Disease Relevance 0.34 Pain Relevance 0.49
Prolactin levels rose in response to surgery and/or anesthesia and remained elevated only in tumor-bearing mice who underwent mammectomy, an occurrence similar to that reported in humans.
Positive_regulation (rose) of Prolactin associated with anesthesia and cancer
4) Confidence 0.70 Published 1989 Journal Plast. Reconstr. Surg. Section Abstract Doc Link 2928403 Disease Relevance 0.78 Pain Relevance 0.10
However, pituitary grafting resulted in the increase in PRL and GH levels compared with age-matched controls.
Positive_regulation (increase) of PRL in pituitary
5) Confidence 0.67 Published 1993 Journal In Vivo Section Abstract Doc Link 8364165 Disease Relevance 0.49 Pain Relevance 0.42
These findings altogether suggest that the spontaneous development of adenomyosis in SHN mice may be related to the elevation in PRL and GH levels as a function of age.
Positive_regulation (elevation) of PRL associated with dismenorea
6) Confidence 0.67 Published 1993 Journal In Vivo Section Abstract Doc Link 8364165 Disease Relevance 0.55 Pain Relevance 0.41
The previous and the present findings conclude that progesterone stimulates mammary tumourigenesis by acting synergistically with prolactin and oestrogen when the latter hormones are at normal levels, but it prevents tumourigenesis by acting antagonistically with high levels of prolactin and oestrogen.
Positive_regulation (levels) of prolactin
7) Confidence 0.50 Published 1989 Journal Anticancer Res. Section Abstract Doc Link 2817809 Disease Relevance 0.22 Pain Relevance 0.34
Prolactin levels 24 hours postoperatively were significantly elevated (p less than 0.01) in groups 2 to 4 when compared with group 1.
Positive_regulation (elevated) of Prolactin
8) Confidence 0.50 Published 1989 Journal Plast. Reconstr. Surg. Section Abstract Doc Link 2928403 Disease Relevance 0.69 Pain Relevance 0
Prolactin levels rose in response to surgery and/or anesthesia and remained elevated only in tumor-bearing mice who underwent mammectomy, an occurrence similar to that reported in humans.
Positive_regulation (elevated) of Prolactin associated with anesthesia and cancer
9) Confidence 0.47 Published 1989 Journal Plast. Reconstr. Surg. Section Abstract Doc Link 2928403 Disease Relevance 0.78 Pain Relevance 0.10
On the other hand, concentrations of PRL and GH significantly increased with age.
Positive_regulation (increased) of PRL
10) Confidence 0.45 Published 1993 Journal In Vivo Section Abstract Doc Link 8364165 Disease Relevance 0.53 Pain Relevance 0.40
In addition, prolactin levels were increased in progestin-treated animals of both strains (P < 0.001, two-way ANOVA; Figure 6b).
Positive_regulation (increased) of prolactin associated with sprains and strains
11) Confidence 0.40 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 0.76 Pain Relevance 0
Morphine and methadone decrease LH and testosterone, and increase prolactin.
Positive_regulation (increase) of prolactin associated with methadone and morphine
12) Confidence 0.39 Published 1987 Journal Adv Contracept Deliv Syst Section Abstract Doc Link 12341906 Disease Relevance 0.70 Pain Relevance 0.45
These findings suggest that increases in the amount of functional PRLR are in fact a result of the progress of adenomyotic changes, rather than simply a result of elevated circulating prolactin levels.
Positive_regulation (elevated) of prolactin associated with dismenorea
13) Confidence 0.38 Published 1997 Journal Life Sci. Section Abstract Doc Link 9126864 Disease Relevance 0.49 Pain Relevance 0.49
Hormonal evaluation at the time of admission was significant for a mildly elevated prolactin level of 55.9 ng/mL (normal range 0.4–29.0 ng/mL).
Positive_regulation (elevated) of prolactin
14) Confidence 0.30 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2678126 Disease Relevance 1.75 Pain Relevance 0.04
8-fold increase of GH and a 2-fold increase of PRL.
Positive_regulation (increase) of PRL
15) Confidence 0.29 Published 2007 Journal Pituitary Section Body Doc Link PMC2045692 Disease Relevance 0.30 Pain Relevance 0.08
In addition, most patients also exhibit a moderate increase in serum prolactin concentration, which regresses after removal of the ectopic GHRH source, supporting the notion that GHRH is directly responsible for the hyperprolactinemia, a finding also present in hGHRH-transgenic mice [34].
Positive_regulation (increase) of prolactin associated with targeted disruption and galactorrhea
16) Confidence 0.29 Published 2007 Journal Pituitary Section Body Doc Link PMC2045692 Disease Relevance 1.31 Pain Relevance 0
8-fold increase of GH and a 3.5-fold increase of PRL.
Positive_regulation (increase) of PRL
17) Confidence 0.21 Published 2007 Journal Pituitary Section Body Doc Link PMC2045692 Disease Relevance 0.52 Pain Relevance 0
Morphine alone induced both an increase in TSH and PRL serum levels and a decrease in cortisol serum levels with no changes in GH serum levels.
Positive_regulation (increase) of PRL associated with morphine
18) Confidence 0.19 Published 1987 Journal Biomed. Pharmacother. Section Abstract Doc Link 3663877 Disease Relevance 0 Pain Relevance 1.57
IGF-I concentration amounted to 86 nmol/l (normal upper level for her age 32 nmol/l) Thyroid and adrenal functions were normal, but prolactin concentration was elevated to 20 ?
Positive_regulation (elevated) of prolactin in Thyroid
19) Confidence 0.19 Published 2007 Journal Pituitary Section Body Doc Link PMC2045692 Disease Relevance 0.51 Pain Relevance 0
Thyroid and adrenal functions were normal, but prolactin concentration was elevated to 21 ?
Positive_regulation (elevated) of prolactin in Thyroid
20) Confidence 0.19 Published 2007 Journal Pituitary Section Body Doc Link PMC2045692 Disease Relevance 0.31 Pain Relevance 0.09

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